Dr. Pradipta Mukherjee Profile

Dr. Pradipta Mukherjee

Post Doctoral Researcher at Univ of Tsukuba

SPIE Involvement:

Author

Area of Expertise:

Optical Coherence Tomography , Polarization , Polarimetry

Publications (47)

Proceedings Article | 1 January 2025 Paper

Time-lapse imaging of tumor spheroid drug response by dynamic optical coherence tomography integrated with cell cultivation chamber

Ibrahim Abd El-Sadek, Rion Morishita, Atsuko Furukawa, Masato Iwatsuki, Shuichi Makita, Pradipta Mukherjee, Satoshi Matsusaka, Yoshiaki Yasuno

Proceedings Volume 13487, 1348705 (2025) https://doi.org/10.1117/12.3032327

KEYWORDS: Optical coherence tomography, Biological imaging, Tumors, Imaging systems, Biological samples, Signal intensity, Microscopes, Tissues, System integration

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Proceedings Article | 13 March 2024 Poster

Investigating the dependency of dynamic optical coherence tomography signals on resolution and wavelength by experimental and simulation approaches

Shumpei Fujimura, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Yiheng Lim, Lida Zhu, Rion Morishita, Yuanke Feng, Yoshiaki Yasuno

Proceedings Volume PC12830, PC128301E (2024) https://doi.org/10.1117/12.3005612

KEYWORDS: Optical coherence tomography, Computing systems, Tissues, Image resolution, Visualization, Spectral resolution, Numerical simulations, Modeling, Diffusion, Breast

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Proceedings Article | 13 March 2024 Poster

Stokes analysis of optic axis orientation in single-mode fiber polarization-sensitive optical coherence tomography

Yiheng Lim, Pradipta Mukherjee, Shuichi Makita, Yoshiaki Yasuno

Proceedings Volume PC12830, PC128300V (2024) https://doi.org/10.1117/12.3001461

KEYWORDS: Tissue optics, Optical coherence tomography, Tissues, Wave plates, Single mode fibers, Birefringence, Biological research, 3D printing, Singular optics, Reconstruction algorithms

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Proceedings Article | 13 March 2024 Presentation

Longitudinal drug response imaging of tumor spheroids using dynamic optical coherence tomography in conjunction with cell cultivation

Ibrahim Abd El-Sadek, Rion Morishita, Masato Iwatsuki, Atsuko Furukawa, Shuichi Makita, Pradipta Mukherjee, Satoshi Matsusaka, Yoshiaki Yasuno

Proceedings Volume PC12841, PC1284103 (2024) https://doi.org/10.1117/12.3000669

KEYWORDS: Biological imaging, Tumors, Optical coherence tomography, Biological samples, Vacuum chambers, Microscopes, Imaging systems, Visualization, Tomography, Tissues

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Proceedings Article | 13 March 2024 Presentation

Wavelength and resolution dependency of dynamic optical coherence tomography

Shumpei Fujimura, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Yiheng Lim, Lida Zhu, Rion Morishita, Yuanke Feng, Yoshiaki Yasuno

Proceedings Volume PC12854, PC128540D (2024) https://doi.org/10.1117/12.3001490

KEYWORDS: Optical coherence tomography, Tissues, Image resolution, Computing systems, Visualization, Spectral resolution, Numerical simulations, Modeling, Diffusion, Breast cancer

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Proceedings Article | 13 March 2024 Presentation

In-vivo dynamic and multi-contrast imaging of human skin by motion-suppressed dynamic optical coherence tomography

Yu Guo, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Yiqiang Zhu, Yoshiaki Yasuno

Proceedings Volume 12816, 1281602 (2024) https://doi.org/10.1117/12.3001667

KEYWORDS: Optical coherence tomography, In vivo imaging, Skin, Biological samples, Visualization, Visual analytics, Tissues, Statistical analysis, Raster graphics, Mode conditioning cables

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Proceedings Article | 13 March 2024 Presentation

Studying the effect of gluconeogenesis inhibitor drug on liver functionality using dynamic optical coherence tomography

Pradipta Mukherjee, Shinichi Fukuda, Donny Lukmanto, Kosuke Okada, Thi Hang Tran, Ibrahim Abd El-Sadek, Shuichi Makita, Yoshiaki Yasuno

Proceedings Volume PC12841, PC1284104 (2024) https://doi.org/10.1117/12.3000670

KEYWORDS: Optical coherence tomography, Liver, Animal model studies, Imaging systems, Coherence imaging, 3D projection, Tomography, Tissues, Shadows, Scattering

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Proceedings Article | 13 March 2024 Presentation

Characterizing intracellular activities of dynamic optical coherence tomography: a mathematical modeling approach

Yuanke Feng, Shumpei Fujimura, Yiheng Lim, Thitiya Seesan, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Yoshiaki Yasuno

Proceedings Volume PC12854, PC128540C (2024) https://doi.org/10.1117/12.3001296

KEYWORDS: Optical coherence tomography, Mathematical modeling, Computer simulations, Signal intensity, Particles, Modeling, Light scattering, Diffusion

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Proceedings Article | 13 March 2024 Poster + Paper

Mathematical modeling of intracellular and intratissue activities for understanding dynamic optical coherence tomography signals

Yuanke Feng, Shumpei Fujimura, Yiheng Lim, Thitiya Seesan, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Yoshiaki Yasuno

Proceedings Volume 12830, 128300H (2024) https://doi.org/10.1117/12.3005637

KEYWORDS: Optical coherence tomography, Mathematical modeling, Motion models, Tissues, Diffusion, Voxels, Computer simulations, Particles, Speckle pattern, Numerical simulations

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Proceedings Article | 13 March 2024 Presentation + Paper

In vivo dynamic optical coherence tomography with hardware- and software-based motion correction

Yu Guo, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Yiqiang Zhu, Yoshiaki Yasuno

Proceedings Volume 12830, 128300Y (2024) https://doi.org/10.1117/12.3005623

KEYWORDS: Optical coherence tomography, In vivo imaging, Skin, Biological imaging, Tissues, Biological samples, Angiography

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Proceedings Article | 13 March 2024 Presentation + Paper

Quantitative dynamic optical coherence tomography by multi-time-window signal intensity variance

Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Tanatchaya Seesan, Yiheng Lim, Tomoko Mori, Atsuko Furukawa, Satoshi Matsusaka, Shuichi Makita, Yoshiaki Yasuno

Proceedings Volume 12830, 128300R (2024) https://doi.org/10.1117/12.3003694

KEYWORDS: Optical coherence tomography, Fluorescence, Tumors, Signal intensity, Visualization, Computer simulations, Tissues, Speckle, Numerical simulations, Vacuum chambers

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Proceedings Article | 12 March 2024 Presentation + Paper

Optic axis imaging of biological samples by Jones matrix optical coherence tomography

Yiheng Lim, Pradipta Mukherjee, Shuichi Makita, Yoshiaki Yasuno

Proceedings Volume 12845, 128450A (2024) https://doi.org/10.1117/12.3002421

KEYWORDS: Tissue optics, Tissues, Optical coherence tomography, Reconstruction algorithms, Biomedical optics, Polarization, 3D printing, Mueller matrices

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Proceedings Article | 14 August 2023 Paper

New formulation of OCT for analytical signal-to-speckle separation and volumetric differential contrast imaging

Kiriko Tomita, Shuichi Makita, Naoki Fukutake, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Antonia Lichtenegger, Yoshiaki Yasuno

Proceedings Volume 12632, 126320V (2023) https://doi.org/10.1117/12.2670518

KEYWORDS: Optical coherence tomography, Point spread functions, Speckle, Signal processing, Signal analyzers, In vivo imaging, Artificial intelligence, Refractive index, Microscopy, Mathematical modeling

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Proceedings Article | 11 August 2023 Paper

Label-free intra-tissue activity imaging of alveolar organoid with three-dimensional dynamic optical coherence tomography

Rion Morishita, Pradipta Mukherjee, Ibrahim Abd El-Sadek, Toshio Suzuki, Antonia Lichtenegger, YiHeng Lim, Yiqiang Zhu, Shuichi Makita, Yuki Yamamoto, Tetsuharu Nagamoto, Yoshiaki Yasuno

Proceedings Volume 12632, 126321C (2023) https://doi.org/10.1117/12.2670861

KEYWORDS: Optical coherence tomography, 3D image processing, 3D modeling, Visualization, Tissues, Stem cells, Scattering, Medical research, Light sources, In vitro testing

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Proceedings Article | 11 August 2023 Paper

Human-derived tumor-spheroid-based anti-cancer drugs testing using dynamic optical coherence tomography

I. Abd El-Sadek, R. Morishita, T. Mori, S. Makita, P. Mukherjee, S. Matsusaka, Y. Yasuno

Proceedings Volume 12632, 126321A (2023) https://doi.org/10.1117/12.2670856

KEYWORDS: Optical coherence tomography, Tumors, Optical testing, Visualization, Tissues, Tomography, Shrinkage, Raster graphics, Fluorescence imaging, Breast cancer

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Proceedings Article | 27 March 2023 Poster

Label-free dynamic OCT (D-OCT) based evaluation of tumor spheroids

Ibrahim Abd El-Sadek, Rion Morishita, Tomoko Mori, Shuichi Makita, Pradipta Mukherjee, Satoshi Matsusaka, Yoshiaki Yasuno

Proceedings Volume PC12367, PC123671O (2023) https://doi.org/10.1117/12.2651543

KEYWORDS: Tumors, Optical coherence tomography, Tissues, Microscopy, Visualization, Solids, Medicine, Luminescence, In vivo imaging, Cancer

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Proceedings Article | 27 March 2023 Poster

Label-free ex-vivo animal tissue metabolism investigation using dynamic optical coherence tomography

Pradipta Mukherjee, Shinichi Fukuda, Donny Lukmanto, Toshiharu Yamashita, Kosuke Okada, Shuichi Makita, Ibrahim Abd El-Sadek, Arata Miyazawa, Yoshiaki Yasuno

Proceedings Volume PC12367, PC123671J (2023) https://doi.org/10.1117/12.2649592

KEYWORDS: Mode conditioning cables, Tissues, Kidney, Optical coherence tomography, Tissue optics, Liver, Animal model studies, Imaging systems, Structural dynamics, Liver cancer

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Proceedings Article | 27 March 2023 Poster

Disperse scatterer model of OCT and its application to design volumetric differential contrast imaging

Kiriko Tomita, Shuichi Makita, Naoki Fukutake, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Antonia Lichtenegger, Junya Tamaoki, Lixuan Bian, Makoto Kobayashi, Tmoko Mori, Satoshi Matsusaka, Yoshiaki Yasuno

Proceedings Volume PC12367, PC123671Q (2023) https://doi.org/10.1117/12.2652325

KEYWORDS: Optical coherence tomography, Refractive index, Digital image correlation, Signal processing, Coherence imaging, 3D modeling, Statistical modeling, Optical imaging, Microscopy, Laser beam diagnostics

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Proceedings Article | 16 March 2023 Presentation + Paper

Dynamic OCT to visualize development of cotyledon vessels in sprouts

Y. Lim, S. Kojima, P. Mukherjee, I. Abd El-Sadek, S. Makita, Y. Yasuno

Proceedings Volume 12391, 123910O (2023) https://doi.org/10.1117/12.2648801

KEYWORDS: Optical coherence tomography, Visualization, Biological imaging, Tissues, In vivo imaging, Biological research

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Proceedings Article | 16 March 2023 Presentation

Volumetric differential contrast imaging by computationally augmented optical coherence tomography microscopy (Conference Presentation)

Kiriko Tomita, Shuichi Makita, Naoki Fukutake, Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Antonia Lichtengger, Junya Tamaoki, Lixuan Bian, Makoto Kobayashi, Tomoko Mori, Satoshi Matsusaka, Yoshiaki Yasuno

Proceedings Volume PC12391, PC1239111 (2023) https://doi.org/10.1117/12.2648746

KEYWORDS: Optical coherence tomography, Microscopy, Optical microscopy, Refractive index, Digital image correlation, 3D modeling, Signal processing, Tumors, Optical imaging, Laser beam diagnostics

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Proceedings Article | 16 March 2023 Presentation

Non-invasive and label-free zebrafish investigations using polarization-sensitive optical coherence tomography (Conference Presentation)

Antonia Lichtenegger, Junya Tamaoki, Pradipta Mukherjee, Roxane Licandro, Lida Zhu, Tomoko Mori, Rion Morishita, Lixuan Bian, Ibrahim Abd El-Sadek, Shuichi Makita, Konrad Leskovar, Satoshi Matsusaka, Martin Distel, Makoto Kobayashi, Bernhard Baumann, Yoshiaki Yasuno

Proceedings Volume PC12391, PC123910Z (2023) https://doi.org/10.1117/12.2646760

KEYWORDS: Optical coherence tomography, Tumors, Prototyping, Polarization, 3D modeling, 3D image processing, Tumor growth modeling, Image resolution, Visualization, Tissues

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Proceedings Article | 9 March 2023 Presentation

Low- and high-resolution volumetric dynamic optical coherence tomography of in vitro cell cultures

Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Tomoko Mori, Suzuki Toshio, Antonia Lichtengger, Lim Yi Heng, Zhu Yiqiang, Shuichi Makita, Yuki Yamamoto, Tetsuharu Nagamoto, Satoshi Matsusaka, Yoshiaki Yasuno

Proceedings Volume PC12367, PC123671D (2023) https://doi.org/10.1117/12.2652167

KEYWORDS: Optical coherence tomography, In vitro testing, 3D modeling, Visualization, Tissues, Stereoscopy, Medical research, Lung, Drug development, Cancer

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Proceedings Article | 9 March 2023 Presentation

Improving the estimation accuracy of the scatterer density estimation by accounting for the spatial property of the noise in optical coherence tomography

Thitiya Seesan, Pradipta Mukherjee, Ibrahim Abd El-Sadek, Yiheng Lim, Shuichi Makita, Prathan Buranasiri, Yoshiaki Yasuno

Proceedings Volume PC12367, PC123670Z (2023) https://doi.org/10.1117/12.2648798

KEYWORDS: Optical coherence tomography, Signal to noise ratio, Data modeling, Computer simulations, Tumors, Statistical analysis, Speckle pattern, Sensors, Scattering, Neural networks

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Proceedings Article | 9 March 2023 Presentation

Motion-immune digital refocusing of point-scanning optical coherence tomography using Lissajous scan for in vivo imaging

Shuichi Makita, Lida Zhu, Pradipta Mukherjee, Yiheng Lim, Rion Morishita, Ibrahim Abd El-Sadek, Yoshiaki Yasuno

Proceedings Volume PC12367, PC123670M (2023) https://doi.org/10.1117/12.2647850

KEYWORDS: Optical coherence tomography, In vivo imaging, Tissues, Electronic filtering, Ultrafast phenomena, Ultrafast imaging, Statistical analysis, Spatial resolution, Skin, Reconstruction algorithms

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Proceedings Article | 7 March 2023 Presentation

Renal tubular structure and metabolism revealed by dynamic optical coherence tomography and OCT angiography

Pradipta Mukherjee, Shinichi Fukuda, Donny Lukmanto, Toshiharu Yamashita, Kosuke Okada, Shuichi Makita, Ibrahim Abd El-Sadek, Yiheng Lim, Yoshiaki Yasuno

Proceedings Volume PC12378, PC123780B (2023) https://doi.org/10.1117/12.2648851

KEYWORDS: Optical coherence tomography, Kidney, Mode conditioning cables, Angiography, 3D image processing, Stereoscopy, Injuries, Imaging systems, Statistical analysis, Raster graphics

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Proceedings Article | 7 March 2023 Presentation

Dynamic optical coherence tomography for tumor-spheroid-based anti-cancer-drug testing

Ibrahim Abd El-Sadek, Rion Morishita, Tomoko Mori, Shuichi Makita, Pradipta Mukherjee, Satoshi Matsusaka, Yoshiaki Yasuno

Proceedings Volume PC12378, PC1237804 (2023) https://doi.org/10.1117/12.2649555

KEYWORDS: Tumors, Optical coherence tomography, Tissues, Visualization, Microscopy, 3D acquisition, Tomography, Statistical analysis, Solids, Luminescence

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Proceedings Article | 3 October 2022 Presentation

Longitudinal xenograft zebrafish investigation using polarization-sensitive Jones-matrix optical coherence tomography (Conference Presentation)

Antonia Lichtenegger, Junya Tamaoki, Tomoko Mori, Pradipta Mukherjee, Lida Zhu, Lixuan Bian, Ibrahim Abd El-Sadek, Shuichi Makita, Satoshi Matsusaka, Makoto Kobayashi, Bernhard Baumann, Yoshiaki Yasuno

Proceedings Volume 12223, 122230F (2022) https://doi.org/10.1117/12.2632878

KEYWORDS: Optical coherence tomography, Polarization, Tumors, Tumor growth modeling, Tissue optics, Scattering, Prototyping, Genetics, Cancer, Breast cancer

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Proceedings Article | 7 March 2022 Presentation + Paper

Rapid, non-destructive, and volumetric characterization of zebrafish tumor models using Jones-matrix optical coherence tomography

Antonia Lichtenegger, Pradipta Mukherjee, Lida Zhu, Shuichi Makita, Konrad Leskovar, Martin Distel, Yoshiaki Yasuno, Bernhard Baumann

Proceedings Volume 11948, 119480D (2022) https://doi.org/10.1117/12.2606982

KEYWORDS: Tumors, Polarization, Birefringence, Optical coherence tomography, Eye, Brain, Nondestructive evaluation, Photomicroscopy, Scattering, Tissues

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Proceedings Article | 7 March 2022 Poster + Presentation + Paper

Multi-focus average for multiple scattering noise suppression in optical coherence tomography

Lida Zhu, Shuichi Makita, Antonia Litchtenegger, Junya Tamaoki, Kensuke Oikawa, Pradipta Mukherjee, Yiheng Lim, Makoto Kobayashi, Jiajie Luo, Yoshiaki Yasuno

Proceedings Volume 11948, 119480M (2022) https://doi.org/10.1117/12.2609190

KEYWORDS: Optical coherence tomography, Scattering, Multiple scattering, Tissues, Light scattering

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Proceedings Article | 7 March 2022 Presentation + Paper

Three dimensional tumor spheroid drug response evaluation using OCT based tissue viability evaluation method

Ibrahim Abd El-Sadek, Arata Miyazawa, Tomoko Mori, Larina Tzu-Wei Shen, Shuichi Makita, Pradipta Mukherjee, Satoshi Matsusaka, Yoshiaki Yasuno

Proceedings Volume 11948, 119480A (2022) https://doi.org/10.1117/12.2612128

KEYWORDS: Tumors, Tissues, Optical coherence tomography, Luminescence, 3D image processing, Algorithm development, Tissue optics, Cancer, Visualization, Imaging systems

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Proceedings Article | 7 March 2022 Poster + Presentation + Paper

Sparse frame acquisition toward fast volumetric dynamic optical coherence tomography imaging

Rion Morishita, Ibrahim Abd El-Sadek, Pradipta Mukherjee, Arata Miyazawa, Kiriko Tomita, Shuichi Makita, Yoshiaki Yasuno

Proceedings Volume 11948, 119480I (2022) https://doi.org/10.1117/12.2612715

KEYWORDS: Optical coherence tomography, Coherence imaging, Visualization, Tumors, Raster graphics, Tissues, Optical imaging, Kidney, 3D image processing, Time metrology

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Proceedings Article | 7 March 2022 Presentation

Quantitative scatterer density estimator to characterize tissue-based phantom in optical coherence tomography

Thitiya Seesan, Ibrahim El-Sadek, Pradipta Mukherjee, Kensuke Oikawa, Prathan Buranasiri, Yoshiaki Yasuno

Proceedings Volume PC11948, PC1194816 (2022) https://doi.org/10.1117/12.2612453

KEYWORDS: Optical coherence tomography, Image processing, Tissue optics, Statistical analysis, Speckle pattern, Speckle, Tumors, Speckle imaging, Spatial resolution, Scattering

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Proceedings Article | 7 March 2022 Presentation

Three-dimensional intracellular motility imaging in non-alcoholic fatty liver disease (NAFLD) using optical coherence tomography

Pradipta Mukherjee, Shinichi Fukuda, Donny Lukmanto, Toshiharu Yamashita, Kosuke Okada, Ibrahim Abd El-Sadek, Arata Miyazawa, Lida Zhu, Shuichi Makita, Tetsuro Oshika, Yoshiaki Yasuno

Proceedings Volume PC11948, PC119480S (2022) https://doi.org/10.1117/12.2611984

KEYWORDS: Liver, Optical coherence tomography, 3D image processing, Tissues, 3D modeling, Volume rendering, Visualization, Imaging systems, Visual process modeling, Particles

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Proceedings Article | 7 March 2022 Presentation

Depth-of-focus extended multi-contrast imaging by polarization-sensitive optical coherence tomography

Lida Zhu, Shuichi Makita, Daisuke Oida, Arata Miyazawa, Kensuke Oikawa, Pradipta Mukherjee, Antonia Lichtenegger, Martin Distel, Yoshiaki Yasuno

Proceedings Volume PC11963, PC119630I (2022) https://doi.org/10.1117/12.2609200

KEYWORDS: Tissues, Optical coherence tomography, Image resolution, Optical imaging, Birefringence, Scattering, Polarization, Collagen, 3D image processing

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Proceedings Article | 2 March 2022 Presentation + Paper

Label-free assessment of renal function with unilateral ureteral obstruction (UUO) model by optical coherence microscopy

Pradipta Mukherjee, Shinchi Fukuda, Donny Lukmanto, Toshiharu Yamashita, Kosuke Okada, Shuichi Makita, Ibrahim Abd El-Sadek, Arata Miyazawa, Lida Zhu, Tetsuro Oshika, Yoshiaki Yasuno

Proceedings Volume 11972, 1197208 (2022) https://doi.org/10.1117/12.2608443

KEYWORDS: Kidney, Tissues, Optical coherence tomography, Visualization, Imaging systems, Optical coherence microscopy, Tissue optics, Mouse models, Visual process modeling, Photomicroscopy

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Proceedings Article | 2 March 2022 Presentation

Label-free three dimensional optical coherence tomography (OCT-) based imaging method for drug response evaluation of human derived tumor spheroids

Ibrahim Abd El-Sadek, Arata Miyazawa, Tomoko Mori, Larina Shen, Shuichi Makita, Pradipta Mukherjee, Satoshi Matsusaka, Yoshiaki Yasuno

Proceedings Volume PC11972, PC119720N (2022) https://doi.org/10.1117/12.2608156

KEYWORDS: Optical coherence tomography, Tumors, 3D image processing, Visualization, Tissues, Algorithm development, Visual analytics, Statistical analysis, Quantitative analysis, Microscopes

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Proceedings Article | 2 March 2022 Presentation

Non-invasive, structural and functional imaging of in vivo zebrafish in various development stages using Jones matrix optical coherence tomography

Antonia Lichtenegger, Pradipta Mukherjee, Junya Tamaoki, Lida Zhu, Lixuan Bian, Ibrahim Abd El-Sadek, Shuichi Makita, Konrad Leskovar, Makoto Kobayashi, Bernhard Baumann, Yoshiaki Yasuno

Proceedings Volume PC11972, PC119720P (2022) https://doi.org/10.1117/12.2606979

KEYWORDS: Optical coherence tomography, In vivo imaging, Polarization, Functional imaging, Visualization, Prototyping, Eye, Birefringence, 3D image processing, Tumor growth modeling

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SPIE Journal Paper | 21 January 2022 Open Access

Multicontrast investigation of in vivo wildtype zebrafish in three development stages using polarization-sensitive optical coherence tomography

Antonia Lichtenegger, Pradipta Mukherjee, Junya Tamaoki, Lixuan Bian, Lida Zhu, Ibrahim Abd El-Sadek, Shuichi Makita, Konrad Leskovar, Makoto Kobayashi, Bernhard Baumann, Yoshiaki Yasuno

JBO, Vol. 27, Issue 01, 016001, (January 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.1.016001

KEYWORDS: Birefringence, Optical coherence tomography, In vivo imaging, Scattering, Polarization, Signal attenuation, Prototyping, Eye, Spinal cord, Skin

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Proceedings Article | 9 December 2021 Paper

Multi-functional optical coherence microscopy for in-vitro and ex-vivo tissue investigation

Yoshiaki Yasuno, Ibrahim Abd El-Sadek, Arata Miyazawa, Larina Tzu-Wei Shen, Thitiya Seesan, Lida Zhu, Daisuke Oida, Kensuke Oikawa, Shuichi Makita, Shinichi Fukuda, Toshiharu Yamashita, Pradipta Mukherjee, Tetsuro Oshika, Prathan Branasiri, Satoshi Matsusaka

Proceedings Volume 11924, 119240H (2021) https://doi.org/10.1117/12.2616034

KEYWORDS: Tissues, Optical coherence tomography, Birefringence, Tumors, Tissue optics, Optical coherence microscopy, In vitro testing, Polarization, Liver, Visualization

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Proceedings Article | 9 March 2021 Poster + Presentation + Paper

Volumetric multi-contrast dynamics imaging for ex vivo liver microvasculature activity visualization using Jones matrix optical coherence tomography

P. Mukherjee, A. Miyazawa, L. T. W. Shen, S. Fukuda, T. Yamashita, Y. Oka, I. Abd El-Sadek, S. Makita, S. Matsusaka, T. Oshika, H. Kano, Y. Yasuno

Proceedings Volume 11630, 116301Q (2021) https://doi.org/10.1117/12.2577994

KEYWORDS: Liver, Visualization, Optical coherence tomography, Tissues, Birefringence, Veins, 3D image processing

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Proceedings Article | 9 March 2021 Presentation + Paper

OCT based cross-sectional and three-dimensional dynamics imaging for visualization and quantification of tumor spheroid activity

I. Abd El-Sadek, A. Miyazawa, L. T. W. Shen, S. Makita, P. Mukherjee, S. Matsusaka, Y. Yasuno

Proceedings Volume 11630, 116301E (2021) https://doi.org/10.1117/12.2577977

KEYWORDS: Optical coherence tomography, Visualization, 3D image processing, Tumors, Tissues, Volume visualization, Volume rendering, Signal analyzers, Mode conditioning cables, Medicine

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Proceedings Article | 8 March 2021 Presentation + Paper

Multi-contrast imaging with computational refocusing in polarization-sensitive optical coherence tomography

Lida Zhu, Shuichi Makita, Daisuke Oida, Arata Miyazawa, Kensuke Oikawa, Pradipta Mukherjee, Yoshiaki Yasuno

Proceedings Volume 11630, 1163020 (2021) https://doi.org/10.1117/12.2582764

KEYWORDS: Optical coherence tomography, Birefringence, Polarization, Tissues, Silicon, Resolution enhancement technologies, Image resolution, Foam, Biological research, 3D image processing

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Optical coherence tomography (OCT) has been widely used for imaging biological sample due to its capability of three-dimensional (3-D) reconstruction. Recently, polarization-sensitive optical coherence tomography (PSOCT) has been used to investigate polarization properties of samples such as retina and muscle [1,2]. Such extensions provide additional contrasts other than traditional reflected intensity and offer a 3-D multi-functional reconstruction of materials and biological tissue. PS-OCT uses A-scan wise computation to obtain the polarization properties from a set of OCT images. In this computation, the lateral resolution is implicitly assumed as infinitely high. However, the birefringence measurement itself will be affected by the lateral optical resolution, defocus, and aberrations. One simple way to obtain high-resolution birefringent data is to use an objective with higher NA. However, OCT also suffers from the trade-off between the lateral resolution and the depth-of-focus (DOF), which might limit its application in thick samples. There have been various methods to overcome this issue. Hardware solutions such as mechanical depth scanning [3] have been reported, but the additional configurations would increase the complexity of system. On the other hand, computational methods do not require additional hardware set-up and thus can be easily adopted, such as interferometric synthetic aperture microscopy (ISAM) [4] and forward model based computational refocusing [5]. However, to our acknowledgement, there are only few reports of long imaging depth for 3-D birefringence imaging. One presented work combined the ISAM with PS-OCT [6]. But the impact of refocusing on multi-contrast imaging, such as artifact in birefringence measurement, has not been thoroughly investigated. In this paper, we present a DOF extended polarization-sensitive imaging by applying computational refocusing to Jones-matrix based PS-OCT (JM-OCT). Computational refocusing is applied to each of four polarization channels (images) of JM-OCT, and the birefringence and degree-of-polarization-uniformity (DOPU) images are computed from the refocused OCT images. Enhanced lateral resolution away from the focus plane and hence extended DOF are demonstrated through phantom and ex vivo porcine muscle measurements. The ex vivo porcine muscle measurement also suggests that the refocusing may reduce the birefringence artifacts.

Proceedings Article | 5 March 2021 Presentation

Three-dimensional imaging of mouse liver dynamics by polarization-sensitive optical coherence tomography

Pradipta Mukherjee, Arata Miyazawa, Shinichi Fukuda, Toshiharu Yamashita, Ibrahim Abd El-Sadek, Shuichi Makita, Tetsuro Oshika, Yoshiaki Yasuno

Proceedings Volume 11655, 116550O (2021) https://doi.org/10.1117/12.2577974

KEYWORDS: Optical coherence tomography, Liver, 3D image processing, Tissues, Birefringence, Visualization, Polarization, Laser beam diagnostics

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Proceedings Article | 5 March 2021 Presentation

Optical-coherence-tomography based tissue dynamics imaging for longitudinal and drug response evaluation of tumor spheroid

Ibrahim Abd El-Sadek, Arata Miyazawa, Larina Shen, Shuichi Makita, Pradipta Mukherjee, Satoshi Matsusaka, Yoshiaki Yasuno

Proceedings Volume 11655, 116550N (2021) https://doi.org/10.1117/12.2576291

KEYWORDS: Optical coherence tomography, Tissue optics, Tumors, Visualization, Mode conditioning cables, Visual analytics, Algorithm development, Tissues, Signal analyzers, Motion analysis

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Proceedings Article | 15 June 2020 Paper

Numerical jitter estimation for swept source optical coherence tomography

Lida Zhu, Arata Miyazawa, Pradipta Mukherjee, Ibrahim Abd El-Sadek, Kensuke Oikawa, Daisuke Oida, Yoshiaki Yasuno

Proceedings Volume 11521, 115210T (2020) https://doi.org/10.1117/12.2573281

KEYWORDS: Optical coherence tomography, Holography, Polarization, 3D metrology, 3D acquisition, Algorithm development, Computational imaging, Computing systems, Biological research, Volume holography

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Proceedings Article | 15 June 2020 Paper

Quantification of ex-vivo tissue activity by polarization dynamics imaging using Jones matrix optical coherence tomography

Pradipta Mukherjee, Arata Miyazawa, Larina Shen, Shinichi Fukuda, Toshiharu Yamashita, Yuki Oka, Ibrahim Abd El-Sadek, Shuichi Makita, Satoshi Matsusaka, Tetsuro Oshika, Hideaki Kano, Yoshiaki Yasuno

Proceedings Volume 11521, 115210R (2020) https://doi.org/10.1117/12.2573237

KEYWORDS: Tissues, Polarization, Birefringence, Optical coherence tomography, Visualization, Tissue optics, Heart, Medicine, Collagen, Natural surfaces

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Proceedings Article | 21 February 2020 Presentation + Paper

Quantification of ex vivo tissue activity by short and long time-course analysis of multifunctional OCT signals

I. G. Abd El-Sadek, A. Miyazawa, L. T. W. Shen, S. Fukuda, T. Yamashita, Y. Oka, P. Mukherjee, S. Makita, S. Matsusaka, T. Oshika, H. Kano, Y. Yasuno

Proceedings Volume 11228, 112282C (2020) https://doi.org/10.1117/12.2548541

KEYWORDS: Tissues, Optical coherence tomography, Liver, Visualization, Birefringence, Signal attenuation, Colorectal cancer, Image visualization, Polarization, Medicine

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