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The zebrafish is an essential animal model in pre-clinical research, especially in the field of cancer investigations. A polarization sensitive Jones matrix OCT (JM-OCT) prototype operating at 1310 nm was utilized to investigate adult control and tumor zebrafish models. Various anatomical features were characterized based on their inherent scattering and polarization properties. A motorized translation stage in combination with the prototype enabled large field-of-view imaging to investigate whole adult zebrafish non-destructively. The reflectivity, the attenuation coefficient and local polarization parameters such as the birefringence and the degree of polarization uniformity were analyzed to quantify differences in tumor versus control regions.
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Antonia Lichtenegger, Pradipta Mukherjee, Lida Zhu, Shuichi Makita, Konrad Leskovar, Martin Distel, Yoshiaki Yasuno, Bernhard Baumann, "Rapid, non-destructive, and volumetric characterization of zebrafish tumor models using Jones-matrix optical coherence tomography," Proc. SPIE 11948, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVI, 119480D (7 March 2022); https://doi.org/10.1117/12.2606982