In-vivo dynamic and multi-contrast imaging of human skin by motion-suppressed dynamic optical coherence tomography

Yu Guo; Rion Morishita; Ibrahim G. Abd El-Sadek; Pradipta Mukherjee; Yiqiang Zhu; Yoshiaki Yasuno

doi:10.1117/12.3001667

13 March 2024 In-vivo dynamic and multi-contrast imaging of human skin by motion-suppressed dynamic optical coherence tomography

Yu Guo, Rion Morishita, Ibrahim G. Abd El-Sadek, Pradipta Mukherjee, Yiqiang Zhu, Yoshiaki Yasuno

Author Affiliations +

Proceedings Volume 12816, Photonics in Dermatology and Plastic Surgery 2024; 1281602 (2024) https://doi.org/10.1117/12.3001667
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

We demonstrated dynamic optical coherence tomography (D-OCT) to human skin in vivo by applying a sample fixation attachment and bulk motion correction algorithm to correct the motion artifacts. A D-OCT contrast of logarithmic intensity variance (LIV) was calculated. Without sample fixation attachment and the motion correction algorithm, the whole image area exhibited high LIV, and no meaningful structure was seen. The application of the motion correction methods revealed fine en face vessel structures, which cannot be seen in OCTA. The statistically significant motion artifact reduction capability of our motion correction method was also shown by t-test.

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(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

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Yu Guo, Rion Morishita, Ibrahim G. Abd El-Sadek, Pradipta Mukherjee, Yiqiang Zhu, and Yoshiaki Yasuno "In-vivo dynamic and multi-contrast imaging of human skin by motion-suppressed dynamic optical coherence tomography", Proc. SPIE 12816, Photonics in Dermatology and Plastic Surgery 2024, 1281602 (13 March 2024); https://doi.org/10.1117/12.3001667

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KEYWORDS

Optical coherence tomography

In vivo imaging

Skin

Biological samples

Mode conditioning cables

Raster graphics

Statistical analysis

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