The depolarization capabilities of the retinal pigment epithelium (RPE) are known to be dependent on the position at the macula and may be caused or influenced by the concentration of melanin and lipofuscin. In this work, the depolarization distribution of the RPE in a large group of healthy eyes is investigated using polarization-sensitive OCT by calculating the degree of polarization uniformity (DOPU) in a large field of view. The results are compared to diseased eyes (glaucoma, age-related macular degeneration), which might help to detect early pathologic changes of the RPE.
This work introduces a method to objectively and non-invasively detect subretinal fibrosis secondary to neovascular age-related macular degeneration. The method exploits the birefringent properties of fibrous tissue: the axis orientation of fibrous tissues is well-defined, whereas the axis orientation of non-fibrous tissues is random. After removal of the influences from birefringent tissues anterior to the fibrosis, fibrotic scar tissues were the only remaining areas with uniform axis orientation and therefore became distinguishable from healthy tissue. The algorithm detected fibrosis congruent to color fundus photography, which is the current gold standard to diagnose fibrosis.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.