Detection of fibrotic lesions in the human retina using polarization-sensitive OCT

Alice Regina Motschi; Philipp K. Roberts; Sylvia Desissaire; Markus Schranz; Hrvoje Bogunovic; Michael Pircher; Christoph K. Hitzenberger

doi:10.1117/12.2581430

5 March 2021 Detection of fibrotic lesions in the human retina using polarization-sensitive OCT

Alice Regina Motschi, Philipp K. Roberts, Sylvia Desissaire, Markus Schranz, Hrvoje Bogunovic, Michael Pircher, Christoph K. Hitzenberger

Author Affiliations +

Proceedings Volume 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV; 1163015 (2021) https://doi.org/10.1117/12.2581430
Event: SPIE BiOS, 2021, Online Only

Abstract

This work introduces a method to objectively and non-invasively detect subretinal fibrosis secondary to neovascular age-related macular degeneration. The method exploits the birefringent properties of fibrous tissue: the axis orientation of fibrous tissues is well-defined, whereas the axis orientation of non-fibrous tissues is random. After removal of the influences from birefringent tissues anterior to the fibrosis, fibrotic scar tissues were the only remaining areas with uniform axis orientation and therefore became distinguishable from healthy tissue. The algorithm detected fibrosis congruent to color fundus photography, which is the current gold standard to diagnose fibrosis.

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Alice Regina Motschi, Philipp K. Roberts, Sylvia Desissaire, Markus Schranz, Hrvoje Bogunovic, Michael Pircher, and Christoph K. Hitzenberger "Detection of fibrotic lesions in the human retina using polarization-sensitive OCT", Proc. SPIE 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV, 1163015 (5 March 2021); https://doi.org/10.1117/12.2581430

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