We will present near infrared fluorescent single wall carbon nanotube optical reporters that can measure the spatial and temporal dynamics of neuromodulatory molecules with resolutions that elude conventional methods of inquiry. We will present results on the performance of such sensors on catecholinergic neuromodulators such as dopamine. We will additionally present new approaches for deploying such sensors in biological preparations of varying complexity that permit implementation of the sensors in ways that enable highly resolved imaging of synaptic neurochemical efflux. When combined with post hoc immunofluorescence and super resolution imaging, our approach affords studies of the biophysical properties of single synapses.
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