Eavesdropping on neuronal chemical chatter using single wall carbon nanotube optical sensors (Conference Presentation)

Abraham G. Beyene; Chandima Bulumulla; Andrew T. Krasley

doi:10.1117/12.2656350

17 March 2023 Eavesdropping on neuronal chemical chatter using single wall carbon nanotube optical sensors (Conference Presentation)

Abraham G. Beyene, Chandima Bulumulla, Andrew T. Krasley

Author Affiliations +

Proceedings Volume PC12397, Frontiers in Biological Detection: From Nanosensors to Systems XV; PC1239703 (2023) https://doi.org/10.1117/12.2656350
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We will present near infrared fluorescent single wall carbon nanotube optical reporters that can measure the spatial and temporal dynamics of neuromodulatory molecules with resolutions that elude conventional methods of inquiry. We will present results on the performance of such sensors on catecholinergic neuromodulators such as dopamine. We will additionally present new approaches for deploying such sensors in biological preparations of varying complexity that permit implementation of the sensors in ways that enable highly resolved imaging of synaptic neurochemical efflux. When combined with post hoc immunofluorescence and super resolution imaging, our approach affords studies of the biophysical properties of single synapses.

Conference Presentation

Citation Download Citation

Abraham G. Beyene, Chandima Bulumulla, and Andrew T. Krasley "Eavesdropping on neuronal chemical chatter using single wall carbon nanotube optical sensors (Conference Presentation)", Proc. SPIE PC12397, Frontiers in Biological Detection: From Nanosensors to Systems XV, PC1239703 (17 March 2023); https://doi.org/10.1117/12.2656350

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KEYWORDS

Carbon nanotubes

Optical sensors

Short wave infrared radiation

Near infrared

Sensors

Microscopes

Nanosensors

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