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7 March 2022 Affinity of SARS-CoV-2 variants to human ACE2 receptors detected with frequency-locked microtoroid optical resonators
Yisha Tang, Sartanee Suebka, Adley Gin, Phuong-Diem Nguyen, Soo-Kyung Kim, William Goddard, Judith Su
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Proceedings Volume PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX; (2022) https://doi.org/10.1117/12.2610580
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
Vaccines for the COVID-19 pandemic are limited and so effective drugs are needed. The binding affinity of several SARS-CoV-2 variants to human ACE2 receptors was measured using a frequency-locked optical whispering evanescent resonator (FLOWER) system. The advantage of FLOWER is that it is label-free and so drug candidates do not need to be labeled and it is ultra-sensitive so drugs over a wide range of binding affinities can be tested. The dissociation equilibrium constants of spike-RBD wild type as well as two variants, were analyzed and compared. Several drug candidates which inhibit the spike-RBD binding to ACE2, predicted by in-silico simulation, were screened using a competitive binding assay and the corresponding inhibitor constants were measured.
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Yisha Tang, Sartanee Suebka, Adley Gin, Phuong-Diem Nguyen, Soo-Kyung Kim, William Goddard, and Judith Su "Affinity of SARS-CoV-2 variants to human ACE2 receptors detected with frequency-locked microtoroid optical resonators", Proc. SPIE PC11940, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic and Photobiomodulation Therapy XXX, (7 March 2022); https://doi.org/10.1117/12.2610580
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KEYWORDS
Receptors
Optical resonators
Proteins
Resonators
Genetics
Microfluidics
Silica
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