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Coronavirus disease 2019 (COVID-19) has become a global pandemic, causing heavy losses to the global community. Novel Coronavirus development speed, the scope of the large, so that biomedical workers have to face together. Meanwhile COVID-19 (SARS-CoV-2) has a strong infection rate as well as certain mortality rate, which brings challenges to the treatment of the disease. Vaccination is an important means to prevent infectious diseases. At present, many research institutions around the world have launched the research as well as advance of COVID-19 vaccines. The current situation of SARS-CoV2 pandemic has triggered development and use of epidemiological vaccines in the medical community. Aiming at vaccines evolution is to acquire straight as proof of vaccines efficient in defend people from SARS-CoV-2 as well as COVID-19 in order to effective vaccine manufacture will be selectively. One vaccine candidate against COVID-19 may fight acute, disease, either contagion, or a vaccine which reduces anyone the elements may aid in disease control. This article introduces the morphological characteristics, mechanism of action, clinical utility, enhance as well as differences of COVID-19 vaccines development, In order to compare mRNA vaccine, subunit vaccine and attenuated vaccine and studied from multiple medical perspectives to promote the selection and use of vaccine in a safer way and ensure the best efficacy end points, prevent grave pathema and doom, as assessed about phase 3 clinical trials. hoping to help comprehend development as well as vaccination point at COVID-19 vaccine in the future.
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