Transferring automation for large-scale development and production of Invader SNP assays

Bruce P. Neri; R. Ganske; W. Isaczyszyn; Edward L. Beaty

doi:10.1117/12.380503

22 March 2000 Transferring automation for large-scale development and production of Invader SNP assays

Bruce P. Neri, R. Ganske, W. Isaczyszyn, Edward L. Beaty

Proceedings Volume 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing; (2000) https://doi.org/10.1117/12.380503
Event: BiOS 2000 The International Symposium on Biomedical Optics, 2000, San Jose, CA, United States

Abstract

The Human Genome Project has led to the discovery of hundreds of thousands of single nucleotide polymorphisms (SNPs). SNPs can act as genetic markers to create high- density maps of the human genome for large-scale genetic analysis for evaluating links between genetic mutations and human diseases and for performing association studies. To create those maps, assays capable of detecting many different SNPs must be developed rapidly, as additional SNPs are discovered. When both the design of and the technology used in the assays can be partially or fully automated, the development process and the time to results can be accomplished quickly and efficiently. Invader^TM technology offers a highly sensitive signal amplification system that detects and quantifies mutations and SNPs from unamplified human genomic DNA in two sequential steps.

Citation Download Citation

Bruce P. Neri, R. Ganske, W. Isaczyszyn, and Edward L. Beaty "Transferring automation for large-scale development and production of Invader SNP assays", Proc. SPIE 3926, Advances in Nucleic Acid and Protein Analyses, Manipulation, and Sequencing, (22 March 2000); https://doi.org/10.1117/12.380503

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