Dr. Zhenyu Xiong Profile

Dr. Zhenyu Xiong

at Rutgers Cancer Institute of New Jersey

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Proceedings Article | 7 April 2023 Poster + Paper

Eye-lens dose reduction using Region of Interest (ROI) attenuators in neuroimaging

Martina Orji, Chao Guo, Zhenyu Xiong, S. Setlur Nagesh, Stephen Rudin, Daniel Bednarek

Proceedings Volume 12463, 124632V (2023) https://doi.org/10.1117/12.2653984

KEYWORDS: Head, Attenuators, Eye, Signal attenuation, Collimation, Neuroimaging, Visualization, Monte Carlo methods, Signal intensity, Image processing

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Lens dose can be high during neuro-interventional procedures, increasing the risk of cataractogenesis. Although beam collimation can be effective in reducing lens dose, it also restricts the FOV. ROI imaging with a reduced-dose peripheral field permits full-field information with reduced lens dose. This work investigates the magnitude of lens-dose reduction possible with ROI imaging. EGSnrc Monte-Carlo calculations of lens dose were made for the Zubal head phantom as a function of gantry angulation and head shift from isocenter for both large and small FOV’s. The lens dose for ROI attenuators of varying transmission was simulated as the weighted sum of the lens dose from the small ROI FOV and that from the attenuated larger FOV. Image intensity and quantum mottle differences between ROI and periphery can be equalized by image processing. The lens dose varies considerably with beam angle, head shift, and field size. For both eyes, the lens-dose reduction with an ROI attenuator increases with LAO angulation, being highest for lateral projections and lowest for PA. For an attenuator with small ROI field (5 x 5 cm) and 20% transmission, the lens dose for lateral projections is reduced by about 75% compared to a full dose 10 x10 cm FOV, while the reduction ranges between 30 and 40% for PA projections. Use of ROI attenuators can substantially reduce the dose to the lens of the eye for all gantry angles and head shifts, while allowing peripheral information to be seen in a larger FOV.

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