Diffraction-based biosensors that rely on optical scattering are a sensitive approach for biomolecular detection. We
present a Mie surface double-interaction computer study of the in situ assembly of bead-based diffraction gratings on a
gold substrate. The limit of detection for a system having 26 stripes is calculated to be approximately 25 beads in total,
or approximately one bead per stripe in an immunoassay experiment. This sensitivity limit is orders of magnitude better
than label-free molecular sensors, and is consistent with high-speed scanning for high-throughput assays.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.