Dr. Thomas Giesen Profile

Dr. Thomas Giesen

at Praxis Dr. med. Dipl.-Ing Thomas Giesen

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Proceedings Article | 14 August 2019 Presentation

Photodynamic therapy (PDT) based on chlorin e6 in the palliative treatment of head neck malignancies (Conference Presentation)

Thomas Giesen, Sönke Baumann, Jens Buentzel

Proceedings Volume 11070, 110705A (2019) https://doi.org/10.1117/12.2528031

KEYWORDS: Photodynamic therapy, Head, Neck, Chlorine, Cancer, Analytical research, Standards development, Diagnostics and therapeutics, Optical spectroscopy, Spectroscopy

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Objective: Despite its approval in 2004 PDT has not well established in the palliative tumour therapy of head neck cancers (HNC). Furthermore we have no diagnostic and therapeutic standards for this procedure. Material and methods: We performed a retrospective analysis of the treated HNC patients of ORL department Nordhausen between 11-2016 and 10-2018 in order to develop practical standards for daily practice, and to describe new projects of research. We analyzed the data of 35 patients with histological confirmed squamous cell carcinoma. The patients have got 1 mg/kg Chlorin E6 IV. Then we performed PD in optical and/or spectroscopical (405 nm) technique. The application was corrected, and the PDT was done by a red-light system (670 nm). Results: We treated 9 malignancies of the tongue/mouth, 9 laryngeal cancer, 7 malignancies of nose/paranasal sinus, 4 cancer of palatal and buccal region, and 3 pharyngeal cancers. Aims of PDT were 33times tumour reduction, and twice decrease of symptom burden. The follow-up interval was median 5 month (range 1-30); 24 patients are alive, 8 patients died, 3 were lost in follow up. We performed median 2 PDT per patient (range 1-19). The application technique was interstitial in 12 patients, frontal in 10 patients and cylindric in 13 patients. PDT was performed as only therapy in 15 patients, in multimodal combinations in 20 patients. We have registered 14 CR, 10 PR, 10 SD and 1 PD. Conclusion: PDT is an effective procedure to get local control in palliative situation of HNC.

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