KEYWORDS: Magnetic resonance imaging, Imaging systems, Interfaces, Signal detection, Data acquisition, Breast cancer, Tomography, Imaging spectroscopy, Multimodal imaging, Near infrared spectroscopy
A novel MRI-guided near-infrared spectroscopic tomographic imaging system (NIRST) has been developed for breast cancer detection. NIRST imaging for an entire breast can be simultaneously carried out during MRI scanning in less than 4 minutes. Reconstructed phantom images showed clear contrast of a 20 mm inclusion to the background, and the total hemoglobin (HbT) and water concentration values estimated from the reconstructed images of a normal subject were in the same range as those obtained in our previous imaging studies.
KEYWORDS: Breast cancer, Multimodal imaging, Tomography, Magnetic resonance imaging, Optical fibers, Data acquisition, Imaging systems, Interfaces, Near infrared spectroscopy
A novel wearable MRg-NIRST system for breast cancer detection has been designed and developed. In this prototype, eight (8) flex circuit strips, each with six (6) photo-detectors (PDs) and six (6) source fibers, are attached to the breast to collect diffused light. A 6x48 fiber switch and 48 side-firing fibers deliver intensity modulated laser light at six (6) near-infrared wavelengths. Light intensity at each of 2304 source-detector positionsis obtained for T2-MRI guided 3D NIRST image reconstruction. In phantom testing, reconstructed images showed the contrast between tumor/inclusion and normal/background.
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