Mr. Ji Bian Profile

Ji Bian

at Royal North Shore Hospital

SPIE Involvement:

Author

Publications (2)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 13 March 2024 Presentation

Photobiomodulation biphasic mechanisms in the treatment of renal fibrosis: evidence from in vitro and in vivo studies

Peter Bian, Ann Liebert, Helen Huang, Brian Bicknell, Carol Pollock

Proceedings Volume PC12826, PC1282608 (2024) https://doi.org/10.1117/12.3009038

KEYWORDS: In vitro testing, In vivo imaging, Kidney, Parkinson disease, Diseases and disorders, Neurological disorders, Brain diseases, Alzheimer's disease, Urea, Traumatic brain injury

Read Abstract +

Renal disease is a severe and increasing problem with chronic kidney disease (CKD) associated with increasing incidence of obesity and metabolic disease. Current treatments for diabetic kidney disease are limited and generally ineffective, highlighting the need for innovative therapeutic strategies. Photobiomodulation is one such potential therapy. PBM is known to modulate cellular function, suppress inflammation, restore balance redox, and improve mitochondrial activity, all of which are hallmarks of CKD. Here we highlight photobiomodulation treatment for CKD in in vitro and in vivo models, with implications for photobiomodulation mechanisms. In vitro results showed that low-dose photobiomodulation resulted in over-expression of fibronectin and tumour necrosis factor and down-regulation of glutathione peroxidase while high-dose photobiomodulation did not. Similarly, in vivo results also showed that low but not high-dose PBM improved kidney function, decreased blood urea, albumin, albumin-creatinine ratio and other markers of CKD. There were significant microbiome changes associated with photobiomodulation treatment.

Proceedings Article | 7 March 2022 Poster

The effect of photobiomodulation in an in vitro model on chronic kidney disease

Ji Bian, Chungling Huang, Ann Liebert, Brian Bicknell, Xin-Ming Chen, Carol Pollock

Proceedings Volume PC11940, (2022) https://doi.org/10.1117/12.2622566

Read Abstract +

Chronic kidney disease (CKD) is a worldwide public health problem, resulting in a significant burden on the health system. PBM is effective in mitigating inflammation, mitochondrial dysfunction, and oxidative stress, all of which are factors inherent in CKD. The aim of this study was to identify the direct effects of PBM in an in-vitro model of CKD. In vitro human proximal tubular cells (HK2 cells) were pre-treated with low (1.38 J/cm²) or high dosage (2.75J/cm²) of PBM. Cells were then incubated with TGF-β1 (2 ng/ml) for 48 hours with or without PBM irradiation every 24 hours. The SHAM groups were processed under the exact same conditions except in the absence of PBM irradiation. The expression levels of inflammatory markers monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), fibrotic marker fibronectin (FN), antioxidative markers superoxide dismutase 1 (SOD1) and SOD2 were measured by qRT-PCR or ELISA The results showed that TGF-β1 significantly increased MCP-1, TNF-α, and fibronectin mRNA expression in HK2 cells, which was significantly reversed by the low dosage of PBM (0.45 J/cm², P<0.05), but not the higher dosage of PBM (0,9 J/cm²) when compared with the SHAM control group. The dose-response characteristics of PBM observed in this study followed the biphasic pattern. In conclusion, the present study suggests that PBM directly reduced inflammation and fibrosis in kidney tubular cells when used at the appropriate dose.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years