Extracorporeal membrane oxygenation (ECMO) is an invasive technique that is used for patients that have experienced heart or lung failure. Due to the complex nature of this treatment, neurological injuries such as hypoxic ischemic encephalopathy (HIE) or stroke can occur. Conventional neuroimaging is risky for this patient population and only provides a snapshot in time, so continuous non-invasive bedside neuromonitoring. In this study we plan on monitoring cerebral blood flow using diffuse correlation spectroscopy and neural activity with electroencephalography. Correlating blood flow with neural activity will provide insight into the neurovascular coupling between neurologically injured versus normal patients on ECMO.
Effects of extracorporeal membrane oxygenation (ECMO) treatment is a life saving treatment for patients that undergo cardiac or pulmonary arrest and is increasingly being used in adults. However, some adults develop brain injuries during treatment. Current neuroimaging techniques such as CT and MRI are inaccessible for these patients due to the high risk in moving them. In this study, we use diffuse correlation spectroscopy to non-invasively monitor cerebral blood flow in patients at the bedside during ECMO treatment. Using this data alongside physiological data, indices of cerebral autoregulation are calculated to observe how ECMO affects neurological health.
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