Dr. Gregory L. Rorrer Profile

Dr. Gregory L. Rorrer

at Oregon State Univ

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Author

Publications (10)

Proceedings Article | 4 March 2019 Presentation

Fluorescence imaging immuno-assay biosensors on biological photonic crystals (Conference Presentation)

Kenneth Squire, Paul LeDuff, Gregory Rorrer, Alan Wang

Proceedings Volume 10895, 108950I (2019) https://doi.org/10.1117/12.2512116

KEYWORDS: Luminescence, Photonic crystals, Sensors, Ocean optics, Biosensors, Fluorescence spectroscopy, Data acquisition, Signal detection, Biosensing, Molecules

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Optical biosensing has achieved remarkable levels of sensitivity and has enabled early detection of various toxins and biomarkers. Fluorescence spectroscopy is among the most common and powerful optical detection techniques, capable of single molecule detection. This is done by exciting the sample using a light source, collecting the fluorescence light inherent in the sample or on a reporter molecule, and measuring the fluorescence spectrum using a spectrometer. This modality is effective for multiplex sensing as full spectral data is acquired. However, fluorescence spectroscopy requires multiple measurements at multiple points to achieve a representative sampling of a sensor. Fluorescence imaging is a detection modality similar to fluorescence spectroscopy, but replaces the spectrometer with an imager such as a camera thus reducing cost and complexity. Imaging allows data acquisition at multiple points in a large area of your sensor in a single measurement making it a more efficient sensing method but does not acquire spectral data. Both fluorescence sensing modalities have been shown to be very powerful in pristine laboratory settings but when the equipment or measurement area are not ideal, additional enhancement is needed. This can be achieved by implementing a sensing substrate capable of enhancing fluorescence signals to practical detection levels. Diatoms are unicellular marine organisms that grow a biosilica shell called a frustule. These frustules are porous with nanostructured patterns and represent naturally occurring photonic crystals which are known to enhance excitation and emission of fluorophores. In addition to the optical enhancements of diatoms, the large surface area allows for large numbers of analytes to aggregate making fluorescence signals stronger. In this work, we employ naturally occurring photonic crystal diatoms to create a sensor capable of enhancing the fluorescence of a standard sandwich immunoassay. Using this sensor, we achieved detection down to 10-16 M using fluorescence spectroscopy and 10-15 M for fluorescence imaging. These represent a 100× and 10× enhancement for the two respective detection modalities over equivalent, non-diatom sensors. This highlights the capability of our sensor to enhance fluorescence optical signals and its potential to be used in point-of-care biosensing applications.

Proceedings Article | 20 February 2018 Presentation + Paper

Ultra-sensitive fluorescent imaging-biosensing using biological photonic crystals

Kenny Squire, Xianming Kong, Bo Wu, Gregory Rorrer, Alan Wang

Proceedings Volume 10506, 105060K (2018) https://doi.org/10.1117/12.2292289

KEYWORDS: Luminescence, Sensors, Photonic crystals, Biosensors, Biosensing, Image sensors, Chemical analysis, Point-of-care devices, Image processing, Light sources

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Proceedings Article | 22 April 2016 Presentation + Paper

Dual-mode bioenabled nano-plasmonic sensors for biological and chemical detection

Xianming Kong, Kenny Squire, Yuting Xi, Paul LeDuff, Gregory Rorrer, Alan Wang

Proceedings Volume 9725, 97250G (2016) https://doi.org/10.1117/12.2214015

KEYWORDS: Refractive index, Surface enhanced Raman spectroscopy, Silver, Nanoparticles, Glasses, Raman spectroscopy, Nanostructures, Molecules, Plasmonics, Photonic crystals

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Proceedings Article | 22 April 2016 Paper

SERS sensing of sub-nanoliter analyte on diatom biosilica using inkjet printing

Yuting Xi, Xianming Kong, Kenny Squire, Paul LeDuff, Gregory Rorrer, Alan Wang

Proceedings Volume 9724, 972406 (2016) https://doi.org/10.1117/12.2214005

KEYWORDS: Biomedical optics, Surface enhanced Raman spectroscopy, Biological research, Printing, Biosensors, Inkjet technology, Plasmonics, Raman scattering, Microorganisms, Silica, Photonic crystals, Silver, Raman spectroscopy, Nanoparticles, Glasses

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Proceedings Article | 13 May 2015 Paper

Bioenabled SERS substrates for food safety and drinking water monitoring

Jing Yang, Gregory Rorrer, Alan Wang

Proceedings Volume 9488, 948808 (2015) https://doi.org/10.1117/12.2178077

KEYWORDS: Surface enhanced Raman spectroscopy, Raman spectroscopy, Silver, Water, Safety, Spectroscopy, Sensors, Raman scattering, Nanoparticles, Photonic crystals

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Proceedings Article | 13 March 2014 Paper

Label-free optical sensing on hybrid plasmonic-nanobiosilica platforms

Fanghui Ren, Jeremy Campbell, Gregory Rorrer, Alan Wang

Proceedings Volume 8933, 89330J (2014) https://doi.org/10.1117/12.2042429

KEYWORDS: Silver, Surface enhanced Raman spectroscopy, Raman spectroscopy, Glasses, Nanoparticles, Quartz, Raman scattering, Resonance enhancement, Optical sensing, Silica

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Proceedings Article | 1 October 2013 Paper

Integration of biological photonic crystals in dye-sensitized solar cells for enhanced photocurrent generation

Jeremy Campbell, Greg Rorrer

Proceedings Volume 8817, 88170Q (2013) https://doi.org/10.1117/12.2024520

KEYWORDS: Reflectivity, Dye sensitized solar cells, Transmittance, Photonic crystals, Nanoparticles, Scattering, Control systems, Silica, Mie scattering, Titanium dioxide

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Proceedings Article | 12 April 2013 Paper

Surface-enhanced Raman scattering on diatom biosilica photonic crystals

Fanghui Ren, Jeremy Campbell, Dihan Hasan, Xiangyu Wang, Gregory Rorrer, Alan Wang

Proceedings Volume 8598, 85980N (2013) https://doi.org/10.1117/12.2009375

KEYWORDS: Silver, Glasses, Nanoparticles, Photonic crystals, Raman spectroscopy, Gaussian beams, Raman scattering, Plasmonics, Flat glass, Annealing

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Proceedings Article | 5 May 2009 Paper

Detection of immunocomplex formation by enhanced photoluminescence of antibody-functionalized diatom biosilica

Debra Gale, Timothy Gutu, Jun Jiao, Chih-Hung Chang, Gregory Rorrer

Proceedings Volume 7321, 732104 (2009) https://doi.org/10.1117/12.819153

KEYWORDS: Luminescence, Silica, Thin films, Transmission electron microscopy, Gold, Nanoparticles, Magnesium, Electrons, Scanning electron microscopy, Glasses

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Proceedings Article | 11 September 2007 Paper

Biological fabrication of nanostructured silicon-germanium photonic crystals possessing unique photoluminescent and electroluminescent properties

Gregory Rorrer, Clayton Jeffryes, Chih-hung Chang, Doo-Hyoung Lee, Timothy Gutu, Jun Jiao, Raj Solanki

Proceedings Volume 6645, 66450A (2007) https://doi.org/10.1117/12.735365

KEYWORDS: Electroluminescence, Germanium, Photonic crystals, Silicon, Dielectrics, Nanolithography, Silica, Luminescence, Visible radiation, Hafnium

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Showing 5 of 10 publications

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