We present results from depth-resolved light scattering measurements of triple transgenic mouse retinas for Alzheimer’s Disease (AD) using a multimodal coherent imaging system. Use of a co-registered angle-resolved low-coherence interferometry (a/LCI) and optical coherence tomography (OCT) system allows unique analysis that is otherwise unavailable using a single modality to provide complementary information on tissue structural changes associated with AD. This abstract summarizes the light scattering parameters drawn using this system at selective retinal layers guided by OCT image segmentation. Future developments of this combined system for human retinal imaging, which involve a low-cost OCT engine, are also discussed.
Angle-resolved low-coherence interferometry (a/LCI) is an optical technique which uses inverse models of light scattering to predict the size and density of cell nuclei, a significant biomarker of precancer. In recent years, substantial progress has occurred in a/LCI technology, particularly in novel instrumentation for the detection of dysplasia in the cervix and the esophagus. This abstract summarizes recent developments in a/LCI, with a focus on developments over the previous four years. Clinical studies in the cervix, novel optical instrumentation addressing the cervix and esophagus, and novel applications related to Alzheimer’s disease are discussed.
Optical coherence tomography (OCT) is currently recognized as the gold standard for identifying retinal structural abnormalities in ophthalmology. However, its availability is often limited to large eye centers and research labs due to its high cost and lack of portability. We present a low-cost, portable spectral-domain OCT system with a total cost of materials under $6,000. Compared to current commercial systems, our design offers 50% size reduction and over 80% cost reduction. Image acquisition interface is incorporated and displayed onto a mounted 7-inch touchscreen. Human retinal imaging is demonstrated, and performance is compared with a commercial OCT system. Based on contrast-to-noise ratio analysis, the low-cost OCT demonstrates comparable imaging capabilities.
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