There is strong medical demand for continuous CO2 partial pressure (pCO2) monitoring. While there has been significant progress in the development of CO2 sensors, their implementation with optical wearable device remains under-explored. We have developed highly sensitive, rapidly responding, humidity insensitive and photostable CO2 sensing materials that can be used with optical wireless wearable device for real-time monitoring pCO2. The preliminary results reveal the prototype device is able to reliably detect reversible CO2 changes within physiological ranges.
We present the creation of wearable devices that measure transcutaneous partial oxygen or carbon dioxide pressure (tcpO2 or tcpCO2) non-invasively. The devices are highly sensitive to the physiological pO2/pCO2, and detects changes in luminescence (lifetime or ratiometric brightness) of mellaporphyrins or HPTS dye molecules embedded within breathable, hydrophobic films. Our first in human measurements reveal the devices are able to detect quick and subtle changes in tcpO2 due to local and systemic changes in blood flow of skin or deeper muscle tissue. Models to extract tissue oxygenation and oxygen consumption rate are explored.
A virtual outreach program was developed specifically for the field of biophotonics. The program consisted of hands-on activities using kits sent to students in advance, real-time video lab tours and prerecorded video content.
We present a wireless, wearable device to measure transcutaneous partial oxygen pressure (tcpO2) non-invasively. The device, tuned to physiological range pO2, detects changes in phosphorescence lifetime and intensity of ultra-bright metalloporphyrins embedded within breathable films. We have implemented machine learning algorithms to improve the accuracy of the measurements against changes in temperature, photobleaching, inter-device/film variations, etc. Our first in human measurements reveal the devices are able to detect quick and subtle changes in tcpO2 due to local and systemic changes in blood flow of skin or deeper muscle tissue. Models to extract tissue oxygenation and oxygen consumption rate are explored.
We have developed different portable tools based on phosphorescence lifetime and intensity measurements to be used together with syringes, needles, and catheters to measure oxygen partial pressure deep inside tissue with the aim to improve the assessment of acute compartment syndrome (ACS). Due to their portability and universality, the tools will also be useful in other hypoxia-related conditions such as vascular diseases, diabetic wounds, cancer, and traumatic injuries. We will present designs as well as results from in vivo porcine model studies.
Wearable devices have found widespread application in recent years as consumer electronics for sports and health tracking. A metric of health which is overlooked in currently available technology is the measurement of oxygen in living tissue, a key component in the cellular energy production. We report on the development of an optical wireless wearable prototype for transcutaneous oxygen monitoring based on the phosphorescence emission of a highly breathable oxygen sensing film. The device is truly wearable, weighs under 20 grams,is completely self-contained, requires no external readout electronics and is highly sensitive to oxygen in the physiological range.
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