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1 February 2013 Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser
Teresa Torzicky, Sebastian Marschall, Michael Pircher, Bernhard Baumann, Marco Bonesi, Stefan Zotter, Erich Götzinger, Wolfgang Trasischker, Thomas Klein, Wolfgang Wieser, Benjamin R. Biedermann, Robert A. Huber, Peter E. Andersen, Christoph K. Hitzenberger
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Journal of Biomedical Optics, Vol. 18, Issue 2, 026008 (February 2013). https://doi.org/10.1117/1.JBO.18.2.026008
Abstract
We present a novel, high-speed, polarization-sensitive, optical coherence tomography set-up for retinal imaging operating at a central wavelength of 1060 nm which was tested for in vivo imaging in healthy human volunteers. We use the system in combination with a Fourier domain mode locked laser with active spectral shaping which enables the use of forward and backward sweep in order to double the imaging speed without a buffering stage. With this approach and with a custom designed data acquisition system, we show polarization-sensitive imaging with an A-scan rate of 350 kHz. The acquired three-dimensional data sets of healthy human volunteers show different polarization characteristics in the eye, such as depolarization in the retinal pigment epithelium and birefringence in retinal nerve fiber layer and sclera. The increased speed allows imaging of large volumes with reduced motion artifacts. Moreover, averaging several two-dimensional frames allows the generation of high-definition B-scans without the use of an eye-tracking system. The increased penetration depth of the system, which is caused by the longer probing beam wavelength, is beneficial for imaging choroidal and scleral structures and allows automated segmentation of these layers based on their polarization characteristics.
CC BY: © The Authors. Published by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
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Teresa Torzicky, Sebastian Marschall, Michael Pircher, Bernhard Baumann, Marco Bonesi, Stefan Zotter, Erich Götzinger, Wolfgang Trasischker, Thomas Klein, Wolfgang Wieser, Benjamin R. Biedermann, Robert A. Huber, Peter E. Andersen, and Christoph K. Hitzenberger "Retinal polarization-sensitive optical coherence tomography at 1060 nm with 350 kHz A-scan rate using an Fourier domain mode locked laser," Journal of Biomedical Optics 18(2), 026008 (1 February 2013). https://doi.org/10.1117/1.JBO.18.2.026008
Published: 1 February 2013
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Cited by 29 scholarly publications and 1 patent.
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KEYWORDS
Optical coherence tomography
Polarization
Birefringence
Imaging systems
Data acquisition
Image segmentation
Modulation
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