Development of quantitative diagnostic observables for age-related macular degeneration using Spectral Domain OCT

Bradley A. Bower; Stephanie J. Chiu; Emily Davies; Anjul M. Davis; Robert J. Zawadzki; Alfred R. Fuller; David F. Wiley; Joseph A. Izatt; Cynthia A. Toth M.D.

doi:10.1117/12.704689

5 March 2007 Development of quantitative diagnostic observables for age-related macular degeneration using Spectral Domain OCT

Bradley A. Bower, Stephanie J. Chiu, Emily Davies, Anjul M. Davis, Robert J. Zawadzki, Alfred R. Fuller, David F. Wiley, Joseph A. Izatt, Cynthia A. Toth M.D.

Author Affiliations +

Proceedings Volume 6426, Ophthalmic Technologies XVII; 64260W (2007) https://doi.org/10.1117/12.704689
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

We report on the development of quantitative, reproducible diagnostic observables for age-related macular degeneration (AMD) based on high speed spectral domain optical coherence tomography (SDOCT). 3D SDOCT volumetric data sets (512 x 1000 x 100 voxels) were collected (5.7 seconds acquisition time) in over 50 patients with age-related macular degeneration and geographic atrophy using a state-of-the-art SDOCT scanner. Commercial and custom software utilities were used for manual and semi-automated segmentation of photoreceptor layer thickness, total drusen volume, and geographic atrophy cross-sectional area. In a preliminary test of reproducibility in segmentation of total drusen volume and geographic atrophy surface area, inter-observer error was less than 5%. Extracted volume and surface area of AMD-related drusen and geographic atrophy, respectively, may serve as useful observables for tracking disease state that were not accessible without the rapid 3D volumetric imaging capability unique to retinal SDOCT.

Citation Download Citation

Bradley A. Bower, Stephanie J. Chiu, Emily Davies, Anjul M. Davis, Robert J. Zawadzki, Alfred R. Fuller, David F. Wiley, Joseph A. Izatt, and Cynthia A. Toth M.D. "Development of quantitative diagnostic observables for age-related macular degeneration using Spectral Domain OCT", Proc. SPIE 6426, Ophthalmic Technologies XVII, 64260W (5 March 2007); https://doi.org/10.1117/12.704689

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