Label-free and highly sensitive optical imaging of detailed microcirculation within meninges and cortex in mice with the cranium left intact

Yali Jia; Ruikang K. Wang

doi:10.1117/1.3432654

1 May 2010 Label-free and highly sensitive optical imaging of detailed microcirculation within meninges and cortex in mice with the cranium left intact

Yali Jia, Ruikang K. Wang

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Journal of Biomedical Optics, Vol. 15, Issue 3, 030510 (May 2010). https://doi.org/10.1117/1.3432654

Abstract

We demonstrate for the first time that the detailed blood flow distribution within intracranial dura mater and cortex can be visualized by an ultrahigh sensitive optical microangiography (UHS-OMAG). The study uses an UHS-OMAG system operating at 1310 nm with an imaging speed at 150 frames per second that requires ~10 s to complete one 3-D scan of ~2.5×2.5 mm². The system is sensitive to blood flow with a velocity ranging from ~4 µm/s to ~23 mm/s. We show superior performance of UHS-OMAG in providing functional images of capillary level microcirculation within meninges in mice with the cranium left intact, the results of which correlate well with the standard dural histopathology.

©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Yali Jia and Ruikang K. Wang "Label-free and highly sensitive optical imaging of detailed microcirculation within meninges and cortex in mice with the cranium left intact," Journal of Biomedical Optics 15(3), 030510 (1 May 2010). https://doi.org/10.1117/1.3432654

Published: 1 May 2010

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