Optical micro-angiography reveals depth-resolved muscular microcirculation

Yali Jia; Ruikang K. Wang

doi:10.1117/12.874225

8 March 2011 Optical micro-angiography reveals depth-resolved muscular microcirculation

Yali Jia, Ruikang K. Wang

Proceedings Volume 7898, Dynamics and Fluctuations in Biomedical Photonics VIII; 789803 (2011) https://doi.org/10.1117/12.874225
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Impaired muscular microcirculation in lower extremities is common in many peripheral vascular diseases (PVD), especially the peripheral arterial disease (PAD). There is a need for an imaging method that can be used to noninvasively visualize depth-resolved microcirculation within muscle tissues. Optical microangiography (OMAG) is a recently developed label-free imaging method capable of producing 3D images of dynamic blood perfusion within micro-circulatory tissue beds at an imaging depth up to ~2 mm, with an imaging sensitivity to the blood flow at ~160 μm/s. In this paper, we demonstrate the utility of OMAG in imaging the detailed blood flow distributions, at microcirculatory level resolution, within skeletal muscles in mice. By use of the mouse model of hind-limb ischemia, we show OMAG can assess the perfusion changes caused by ligation. These findings indicate that OMAG is a promising technique to effectively study skeletal muscle-related vascular disease and their pharmacologic therapies.

Citation Download Citation

Yali Jia and Ruikang K. Wang "Optical micro-angiography reveals depth-resolved muscular microcirculation", Proc. SPIE 7898, Dynamics and Fluctuations in Biomedical Photonics VIII, 789803 (8 March 2011); https://doi.org/10.1117/12.874225

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KEYWORDS

Tissues

Blood circulation

Arteries

Blood

In vivo imaging

Tissue optics

Ischemia

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