Design of a multi-coordinating polymer as a platform for functionalizing metal, metal oxide and semiconductor nanocrystals

Wentao Wang; Xin Ji; Anshika Kapur; Hedi Mattoussi

doi:10.1117/12.2211506

22 April 2016 Design of a multi-coordinating polymer as a platform for functionalizing metal, metal oxide and semiconductor nanocrystals

Wentao Wang, Xin Ji, Anshika Kapur, Hedi Mattoussi

Author Affiliations +

Proceedings Volume 9722, Colloidal Nanoparticles for Biomedical Applications XI; 972203 (2016) https://doi.org/10.1117/12.2211506
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

We introduce a new set of amphiphilic polymers as multifunctional, metal-coordinating ligands adapted to surfacefunctionalize quantum dots (QDs), iron oxide nanoparticles (IONPs) and gold nanoparticles/nanorods (AuNPs/AuNRs). The ligand design relies on the introduction of several anchoring groups, hydrophilic moieties and reactive functionalities into a polymer chain, via one-step nucleophilic addition reaction. Such synthetic scheme also allows the insertion of target biomolecules during the ligand synthesis. This functionalization strategy yields nanocrystals that exhibit long-term colloidal stability over a broad range of biological conditions, such as pH changes and when mixed with growth media. When zwitterion groups are used as hydrophilic motifs, this provides compact nanocrystals that are compatible with conjugation to proteins via metal-polyhistidine self-assembly. In addition, we show that QDs ligated with these polymers can engage in energy or charge transfer interactions. Furthermore, nanocrystals coated with folic acid-modified polymers could promote the delivery of nanoparticle-conjugates into cancer cells via folate receptormediated endocytosis.

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Wentao Wang, Xin Ji, Anshika Kapur, and Hedi Mattoussi "Design of a multi-coordinating polymer as a platform for functionalizing metal, metal oxide and semiconductor nanocrystals", Proc. SPIE 9722, Colloidal Nanoparticles for Biomedical Applications XI, 972203 (22 April 2016); https://doi.org/10.1117/12.2211506

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