Quantum dot systems for specific biosensing applications

Jay L. Nadeau; Samuel J. Clarke; C. Annette Hollmann; Daniel M. Bahcheli; Rafael A. Khatchadourian; Alexia Bachir; Paul Wiseman

doi:10.1117/12.724218

5 February 2007 Quantum dot systems for specific biosensing applications

Jay L. Nadeau, Samuel J. Clarke, C. Annette Hollmann, Daniel M. Bahcheli, Rafael A. Khatchadourian, Alexia Bachir, Paul Wiseman

Author Affiliations +

Proceedings Volume 6448, Colloidal Quantum Dots for Biomedical Applications II; 64480M (2007) https://doi.org/10.1117/12.724218
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Energy transfer between semiconductor nanoparticles (quantum dots) and energy donors or acceptors modulates fluorescence, thus serving as a visual indicator of the interaction. Careful choice of conjugate or capping groups can thus make these particles serve as sensors for specific biological processes and as tools for targeted cell killing. Challenges include creation of stable conjugates, delivery to specific cell populations and intracellular regions, and characterization of fluorescence modulation by energy transfer.

Citation Download Citation

Jay L. Nadeau, Samuel J. Clarke, C. Annette Hollmann, Daniel M. Bahcheli, Rafael A. Khatchadourian, Alexia Bachir, and Paul Wiseman "Quantum dot systems for specific biosensing applications", Proc. SPIE 6448, Colloidal Quantum Dots for Biomedical Applications II, 64480M (5 February 2007); https://doi.org/10.1117/12.724218

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