The effect of Stokes shift in the discrimination of urine of cervical cancer from normal subjects

Ramu Rajasekaran; Elumalai Brindha; Prakasa Rao Aruna; Dornadula Koteeswaran; Singaravelu Ganesan

doi:10.1117/12.2213178

7 March 2016 The effect of Stokes shift in the discrimination of urine of cervical cancer from normal subjects

Ramu Rajasekaran, Elumalai Brindha, Prakasa Rao Aruna, Dornadula Koteeswaran, Singaravelu Ganesan

Proceedings Volume 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis; 97031Q (2016) https://doi.org/10.1117/12.2213178
Event: SPIE BiOS, 2016, San Francisco, California, United States

Abstract

Stokes shift spectroscopy has been considered as a potential tool in characterization of multiple components present in tissues and biofluids. Since, the intensity and resolution of the fluorophores depends on the Stokes shift, different opinion has been reflected by the researchers in fixing the Stokes shift. Also, not many studies have been reported on the characterization of biofluids and especially on the diagnosis of cancer. Urine is considered as an important diagnostic biofluid as it is rich in many metabolites where many of them are native fluorophores. In this study, we aimed at characterizing the urine of normal subjects and patients with cervical cancer as function of different Stokes shift. It is observed that Neopterin and Riboflavin are the main fluorophores contribute to the variation between normal and cervical cancer subjects. Ratio variables based linear discriminant analysis shows that the Stokes shift of 40 nm and 60 nm may be considered for better characterization with better signal to noise ratio when compared to others.

Citation Download Citation

Ramu Rajasekaran, Elumalai Brindha, Prakasa Rao Aruna, Dornadula Koteeswaran, and Singaravelu Ganesan "The effect of Stokes shift in the discrimination of urine of cervical cancer from normal subjects", Proc. SPIE 9703, Optical Biopsy XIV: Toward Real-Time Spectroscopic Imaging and Diagnosis, 97031Q (7 March 2016); https://doi.org/10.1117/12.2213178

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KEYWORDS

Cervical cancer

Cancer

Spectroscopy

Luminescence

Fluorescence spectroscopy

Diagnostics

Tissues

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