Synchronous luminescence spectroscopic characterization of blood elements of normal and patients with cervical cancer

K. Muthuvelu; Sivabalan Shanmugam; Dornadula Koteeswaran; S. Srinivasan; P. Venkatesan; Prakasarao Aruna; Singaravelu Ganesan

doi:10.1117/12.876164

16 February 2011 Synchronous luminescence spectroscopic characterization of blood elements of normal and patients with cervical cancer

K. Muthuvelu, Sivabalan Shanmugam, Dornadula Koteeswaran, S. Srinivasan, P. Venkatesan, Prakasarao Aruna, Singaravelu Ganesan

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Proceedings Volume 7895, Optical Biopsy IX; 78950F (2011) https://doi.org/10.1117/12.876164
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

In this study the diagnostic potential of synchronous luminescence spectroscopy (SLS) technique for the characterization of normal and different pathological condition of cervix viz., moderately differentiated squamous cell carcinoma (MDSCC), poorly differentiated squamous cell carcinoma (PDSCC) and well differentiated squamous cell carcinoma (WDSSC). Synchronous fluorescence spectra were measured for 70 abnormal cases and 30 normal subjects. Characteristic, highly resolved peaks and significant spectral differences between normal and MDSCC, PDSCC and WDSCC cervical blood formed elements were obtained. The synchronous luminescence spectra of formed elements of normal and abnormal cervical cancer patients were subjected to statistical analysis. Synchronous luminescence spectroscopy provides 90% sensitivity and 92.6% specificity.

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K. Muthuvelu, Sivabalan Shanmugam, Dornadula Koteeswaran, S. Srinivasan, P. Venkatesan, Prakasarao Aruna, and Singaravelu Ganesan "Synchronous luminescence spectroscopic characterization of blood elements of normal and patients with cervical cancer", Proc. SPIE 7895, Optical Biopsy IX, 78950F (16 February 2011); https://doi.org/10.1117/12.876164

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