Self-propelled, phage-based magnetoelastic biosentinels for detection of pathogens in liquid

Shin Horikawa; Ruiting Zhao; Yating Chai; Howard C. Wikle; Bryan A. Chin

doi:10.1117/12.2050533

28 May 2014 Self-propelled, phage-based magnetoelastic biosentinels for detection of pathogens in liquid

Shin Horikawa, Ruiting Zhao, Yating Chai, Howard C. Wikle, Bryan A. Chin

Proceedings Volume 9108, Sensing for Agriculture and Food Quality and Safety VI; 910805 (2014) https://doi.org/10.1117/12.2050533
Event: SPIE Sensing Technology + Applications, 2014, Baltimore, MD, United States

Abstract

This paper presents the concept of self-propelled magnetoelastic (ME) biosentinels that seek out and capture pathogenic bacteria in stagnant liquids. These biosentinels are composed of a free-standing, asymmetric-shaped ME resonator coated with a filamentous landscape phage that specifically binds with a pathogen of interest. When a time-varying magnetic pulse is applied, the ME biosentinels can be placed into mechanical resonance by magnetostriction. The resultant asymmetric vibration then generates a net force on the surroundings and hence generates autonomous motion in the liquid. As soon as the biosentinels find and bind with the target pathogen through the phage-based biomolecular recognition, a change in the biosentinel’s resonant frequency occurs, and thereby the presence of the target pathogen can be detected. In order to actuate the ME biosentinels into mechanical resonance of a desired mode, modal analysis using the three-dimensional finite element method was performed. In addition, the design of a magnetic chamber that can control the orientation and/or translation of a biosentinel is discussed.

Citation Download Citation

Shin Horikawa, Ruiting Zhao, Yating Chai, Howard C. Wikle, and Bryan A. Chin "Self-propelled, phage-based magnetoelastic biosentinels for detection of pathogens in liquid", Proc. SPIE 9108, Sensing for Agriculture and Food Quality and Safety VI, 910805 (28 May 2014); https://doi.org/10.1117/12.2050533

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