Pulsed excitation system to measure the resonant frequency of magnetoelastic biosensors

Hong Xie; Yating Chai; Shin Horikawa; Howard C. Wikle; Bryan A. Chin

doi:10.1117/12.2049888

28 May 2014 Pulsed excitation system to measure the resonant frequency of magnetoelastic biosensors

Hong Xie, Yating Chai, Shin Horikawa, Howard C. Wikle, Bryan A. Chin

Proceedings Volume 9108, Sensing for Agriculture and Food Quality and Safety VI; 910804 (2014) https://doi.org/10.1117/12.2049888
Event: SPIE Sensing Technology + Applications, 2014, Baltimore, MD, United States

Abstract

An electrical circuit was designed and tested to measure the resonant frequency of micron-scale magnetoelastic (ME) biosensors using a pulsed wave excitation technique. In this circuit, a square pulse current is applied to an excitation coil to excite the vibration of ME biosensors and a pick-up coil is used to sense the ME biosensor’s mechanical vibration and convert it to an electrical output signal. The output signal is filtered and amplified by a custom designed circuit to allow the measurement of the resonant frequency of the ME biosensor from which the detection of specific pathogens can be made. As a proof-in-concept experiment, JRB7 phage-coated ME biosensors were used to detect different concentrations of Bacillus anthracis Sterne strain spores. A statistically significant difference was observed for concentrations of 5 × 10² spore/ml and above.

Citation Download Citation

Hong Xie, Yating Chai, Shin Horikawa, Howard C. Wikle, and Bryan A. Chin "Pulsed excitation system to measure the resonant frequency of magnetoelastic biosensors", Proc. SPIE 9108, Sensing for Agriculture and Food Quality and Safety VI, 910804 (28 May 2014); https://doi.org/10.1117/12.2049888

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