Biosensing with integrated CMOS nanopores

Ashfaque Uddin; Sukru Yemenicioglu; Chin-Hsuan Chen; Ellie Corgliano; Kaveh Milaninia; Fan Xia; Kevin Plaxco; Luke Theogarajan

doi:10.1117/12.945553

10 October 2012 Biosensing with integrated CMOS nanopores

Ashfaque Uddin, Sukru Yemenicioglu, Chin-Hsuan Chen, Ellie Corgliano, Kaveh Milaninia, Fan Xia, Kevin Plaxco, Luke Theogarajan

Author Affiliations +

Proceedings Volume 8460, Biosensing and Nanomedicine V; 846010 (2012) https://doi.org/10.1117/12.945553
Event: SPIE NanoScience + Engineering, 2012, San Diego, California, United States

Abstract

This paper outlines our recent efforts in using solid-state nanopores as a biosensing platform. Traditionally biosensors concentrate mainly on the detection platform and not on signal processing. This decoupling can lead to inferior sensors and is exacerbated in nanoscale devices, where device noise is large and large dynamic range is required. This paper outlines a novel platform that integrates the nano, micro and macroscales in a closely coupled manner that mitigates many of these problems. We discuss our initial results of DNA translocation through the nanopore. We also briefly discuss the use of molecular recognition properties of aptamers with the versatility of the nanopore detector to design a new class of biosensors in a CMOS compatible platform.

Citation Download Citation

Ashfaque Uddin, Sukru Yemenicioglu, Chin-Hsuan Chen, Ellie Corgliano, Kaveh Milaninia, Fan Xia, Kevin Plaxco, and Luke Theogarajan "Biosensing with integrated CMOS nanopores", Proc. SPIE 8460, Biosensing and Nanomedicine V, 846010 (10 October 2012); https://doi.org/10.1117/12.945553

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