Computer simulation of lipid bilayer detection using ion-sensitive field-effect transistors

Shigeyasu Uno

doi:10.1117/12.906521

2 February 2012 Computer simulation of lipid bilayer detection using ion-sensitive field-effect transistors

Shigeyasu Uno

Proceedings Volume 8231, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VIII; 82310V (2012) https://doi.org/10.1117/12.906521
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Computer simulation of lipid bilayer detection using ion-sensitive field-effect transistors (ISFETs) is presented. Based on a previous work addressing DNA sensing using ISFETs, lipid bilayers on ISFET sensor surface is modeled. The model consists of (a) sensor surface, (b) Stern layer, (c) thin electrolytic layer, (d) lipid bilayer, and (e) semi-infinitely-extended electrolyte domain. Poisson-Boltzmann equation is solved to determine electrostatics taking into account mobile ion charges in electrolyte and lipid charges. The simulation successfully reproduces experimental results of output signal change due to positively-charged lipid molecular concentration, as well as salt ion concentration.

Citation Download Citation

Shigeyasu Uno "Computer simulation of lipid bilayer detection using ion-sensitive field-effect transistors", Proc. SPIE 8231, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VIII, 82310V (2 February 2012); https://doi.org/10.1117/12.906521

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available