Optical characterization of vocal folds with optical coherence tomography

Kathrin Luerssen; Holger Lubatschowski; Hagen Gasse; Rudiger Koch; Martin Ptok

doi:10.1117/12.592630

25 April 2005 Optical characterization of vocal folds with optical coherence tomography

Kathrin Luerssen, Holger Lubatschowski, Hagen Gasse, Rudiger Koch, Martin Ptok

Proceedings Volume 5686, Photonic Therapeutics and Diagnostics; (2005) https://doi.org/10.1117/12.592630
Event: SPIE BiOS, 2005, San Jose, CA, United States

Abstract

Optical coherence tomography (OCT) is a new non-invasive method to investigate biological tissue with a penetration depth of up to three millimeters. In this study OCT was used on the porcine larynx. The vocal folds were assigned to defined areas and examined by OCT followed by traditional histo-morphological analysis. We were able to validate this new method by showing that both the OCT-tomographs and the histological assays showed a clear demarcation of epithelium mucosae from the deeper layers. The current standard procedure to ensure the diagnosis, if tissue is malignant, is still an invasive one. Our results show that OCT allows the collection of crucial information about the quality of morphological changes on a vocal fold without the necessity of being invasive. Thus, we propose that optical coherence tomography should be introduced as a new and easy method for the detection of morphological changes of the vocal fold complementary to other established methods.

Citation Download Citation

Kathrin Luerssen, Holger Lubatschowski, Hagen Gasse, Rudiger Koch, and Martin Ptok "Optical characterization of vocal folds with optical coherence tomography", Proc. SPIE 5686, Photonic Therapeutics and Diagnostics, (25 April 2005); https://doi.org/10.1117/12.592630

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available