Prof. Holger Lubatschowski Profile

Prof. Holger Lubatschowski

CEO at Holger Lubatschowski

SPIE Involvement:

Author

Publications (91)

Proceedings Article | 20 June 2024 Poster + Paper

Real-time video funduscopy with continuously moving fixation target

David Harings, Niklas Bauer, Damian Mendroch, Uwe Oberheide, Holger Lubatschowski

Proceedings Volume 13006, 130061E (2024) https://doi.org/10.1117/12.3017223

KEYWORDS: Eye, Light sources and illumination, Optical coherence tomography, Retina, Visualization, Optic nerve, Ophthalmic imaging, Ophthalmoscopy, Glaucoma, Polarization imaging, Infrared imaging

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Proceedings Article | 13 March 2024 Presentation + Paper

Partial lens refilling to preserve lens accommodation after cataract surgery

Mandy Patzlaff-Günther, Björn Spoida, Alina Rahtz, Maximilian Franke, Michael Fromm, Felix Scheling, Holger Lubatschowski, Jan Hahn, Sonja Johannsmeier, Tammo Ripken

Proceedings Volume 12824, 1282409 (2024) https://doi.org/10.1117/12.3005346

KEYWORDS: Hydrogels, Eye, Cataracts, Lenses, Optical coherence tomography, Surgery, Ray tracing, Materials properties

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Proceedings Article | 7 March 2016 Paper

Time resolved digital-holographic analysis of femtosecond laser-induced photodisruption

Emanuel Saerchen, Johannes Wenzel, Georgios Antonopoulos, Alexander Krueger, Holger Lubatschowski, Tammo Ripken

Proceedings Volume 9706, 97060Q (2016) https://doi.org/10.1117/12.2211013

KEYWORDS: Femtosecond phenomena, Laser therapeutics, Surgery, Pulsed laser operation, Laser vision correction, Laser systems engineering, Laser processing, Laser tissue interaction, Water, Picosecond phenomena, Phase measurement, Laser cutting, Refractive index, Laser beam diagnostics

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SPIE Journal Paper | 28 April 2014 Open Access

Effects of cavitation bubble interaction with temporally separated fs-laser pulses

Nadine Tinne, Gesche Knoop, Nicole Kallweit, Sonja Veith, Sebastian Bleeker, Holger Lubatschowski, Alexander Krüger, Tammo Ripken

JBO, Vol. 19, Issue 04, 048001, (April 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.4.048001

KEYWORDS: Pulsed laser operation, Cavitation, Laser energy, Laser tissue interaction, Laser optics, Laser damage threshold, Photodiodes, Laser systems engineering, Laser cutting, Photography

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Proceedings Article | 26 February 2014 Paper

Pulse-to-pulse interaction analysis and parameter optimization for future-generation ophthalmic laser systems

N. Tinne, B. Kaune, S. Bleeker, H. Lubatschowski, A. Krüger, T. Ripken

Proceedings Volume 8941, 89410D (2014) https://doi.org/10.1117/12.2036170

KEYWORDS: Cavitation, Pulsed laser operation, Laser tissue interaction, Laser cutting, Laser systems engineering, Laser therapeutics, Laser energy, Laser scanners, Photography, Tissues

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Proceedings Article | 26 February 2014 Paper

Digital-holographic analysis of femtosecond laser-induced photodisruption in ocular tissue

Emanuel Saerchen, Kevin Biessy, Björn Kemper, Holger Lubatschowski

Proceedings Volume 8941, 89410E (2014) https://doi.org/10.1117/12.2039477

KEYWORDS: Crystals, Water, Femtosecond phenomena, Laser tissue interaction, Laser cutting, Cavitation, Laser systems engineering, Laser processing, Tissues, Pulsed laser operation

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Proceedings Article | 24 June 2013 Paper

Physics of temporal pulse-to-pulse interaction and its consecution to future generation ophthalmic laser systems

N. Tinne, G. Knoop, N. Kallweit, H. Lubatschowski, A. Krüger, T. Ripken

Proceedings Volume 8803, 880302 (2013) https://doi.org/10.1117/12.2032315

KEYWORDS: Pulsed laser operation, Cavitation, Laser tissue interaction, Laser cutting, Laser optics, Laser systems engineering, Water, Tissue optics, Laser energy, Laser therapeutics

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Proceedings Article | 24 June 2013 Paper

Characterization of Fs-laser induced unintended, periodic structures in hydroxy-ethyl-methacrylat (HEMA)

Emanuel Saerchen, Susann Liedtke, Fabian Schlage, Fabian Will, Holger Lubatschowski

Proceedings Volume 8803, 880305 (2013) https://doi.org/10.1117/12.2032495

KEYWORDS: Pulsed laser operation, Laser cutting, Laser processing, Femtosecond phenomena, Tissues, Ophthalmology, Biomedical optics, Improvised explosive devices, Surgery, Polymers

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Proceedings Article | 15 February 2013 Paper

Impact of a temporal pulse overlap on laser-tissue-interaction of modern ophthalmic laser systems

N. Tinne, G. Knoop, N. Kallweit, E. Lübking, H. Lubatschowski, A. Krüger, T. Ripken

Proceedings Volume 8579, 857903 (2013) https://doi.org/10.1117/12.2003041

KEYWORDS: Pulsed laser operation, Cavitation, Laser tissue interaction, Laser energy, Laser systems engineering, Laser optics, Water, Laser vision correction, Laser scattering, Laser therapeutics

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Proceedings Article | 8 June 2011 Paper

Interaction dynamics of fs-laser induced cavitation bubbles and their impact on the laser-tissue-interaction of modern ophthalmic laser systems

N. Tinne, T. Ripken, H. Lubatschowski, A. Heisterkamp

Proceedings Volume 8092, 80921H (2011) https://doi.org/10.1117/12.889341

KEYWORDS: Cavitation, Laser tissue interaction, Laser vision correction, Laser cutting, Pulsed laser operation, Laser energy, Tissue optics, Fusion energy, Laser systems engineering, Laser therapeutics

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A today well-known laser based treatment in ophthalmology is the LASIK procedure which nowadays includes cutting of the corneal tissue with ultra-short laser pulses. Instead of disposing a microkeratome for cutting a corneal flap, a focused ultra-short laser pulse is scanned below the surface of biological tissue causing the effect of an optical breakdown and hence obtaining a dissection. Inside the tissue, the energy of the laser pulses is absorbed by non-linear processes; as a result a cavitation bubble expands and ruptures the tissue. Hence, positioning of several optical breakdowns side by side generates an incision. Due to a reduction of the amount of laser energy, with a moderate duration of treatment at the same time, the current development of ultra-short pulse laser systems points to higher repetition rates in the range of even Megahertz instead of tens or hundreds of Kilohertz. In turn, this results in a pulse overlap and therefor a probable occurrence of interaction between different optical breakdowns and respectively cavitation bubbles of adjacent optical breakdowns. While the interaction of one single laser pulse with biological tissue is analyzed reasonably well experimentally and theoretically, the interaction of several spatial and temporal following pulses is scarcely determined yet. Thus, the aim of this study is to analyse the dynamic and interaction of two cavitation bubbles by using high speed photography. The applied laser pulse energy, the energy ratio and the spot distance between different cavitation bubbles were varied. Depending on a change of these parameters different kinds of interactions such as a flattening and deformation of bubble shape or jet formation are observed. The effects will be discussed regarding the medical ophthalmic application of fs-lasers. Based on these results a further research seems to be inevitable to comprehend and optimize the cutting effect of ultra-short pulse laser systems with high (> 500 kHz) repetition rates.

Proceedings Article | 16 February 2011 Paper

Lowering threshold energy for femtosecond laser pulse photodisruption through turbid media using adaptive optics

A. Hansen, Tammo Ripken, Ronald Krueger, Holger Lubatschowski

Proceedings Volume 7885, 78850Q (2011) https://doi.org/10.1117/12.873838

KEYWORDS: Adaptive optics, Femtosecond phenomena, Eye, Wavefronts, Eye models, Tissues, Retina, Tissue optics, Optical calibration, Pulsed laser operation

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Proceedings Article | 8 February 2011 Paper

Mechanisms of femtosecond laser cell surgery in the low-density plasma regime

K. Kuetemeyer, R. Rezgui, H. Lubatschowski, A. Heisterkamp

Proceedings Volume 7897, 789704 (2011) https://doi.org/10.1117/12.874147

KEYWORDS: Laser ablation, Surgery, Plasma, Femtosecond phenomena, Ionization, Laser therapeutics, Molecules, Laser damage threshold, Luminescence, Laser vision correction

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SPIE Journal Paper | 1 November 2010 Open Access

Interaction dynamics of spatially separated cavitation bubbles in water

Nadine Tinne, Silvia Schumacher, Valeria Nuzzo, Cord Arnold, Holger Lubatschowski, Tammo Ripken

JBO, Vol. 15, Issue 06, 068003, (November 2010) https://doi.org/10.1117/12.10.1117/1.3526366

KEYWORDS: Cavitation, Pulsed laser operation, Laser tissue interaction, Laser energy, Laser cutting, Laser optics, Fusion energy, Laser vision correction, Objectives, Femtosecond phenomena

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SPIE Journal Paper | 1 September 2010 Open Access

Errata: Repetition rate dependency of reactive oxygen species formation during femtosecond laser-based cell surgery

Judith Baumgart, Kai Kuetemeyer, Holger Lubatschowski, Alexander Heisterkamp, Willem Bintig, Anaclet Ngezahayo, Wolfgang Ertmer

JBO, Vol. 15, Issue 05, 059802, (September 2010) https://doi.org/10.1117/12.10.1117/1.3497003

KEYWORDS: Oxygen, Femtosecond phenomena, Laser therapeutics, Surgery, Laser vision correction, Biophysics, Quantum optics

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Proceedings Article | 28 August 2010 Paper

Ultrashort laser pulse cell manipulation using nano- and micro- materials

Markus Schomaker, Doreen Killian, Saskia Willenbrock, Eric Diebold, Eric Mazur, Willem Bintig, Anaclet Ngezahayo, Ingo Nolte, Hugo Murua Escobar, Christian Junghanß, Holger Lubatschowski, Alexander Heisterkamp

Proceedings Volume 7762, 77623G (2010) https://doi.org/10.1117/12.869054

KEYWORDS: Molecules, Green fluorescent protein, Femtosecond phenomena, Particles, Glasses, Nanoparticles, Luminescence, Ultrafast phenomena, Molecular lasers, Stem cells

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Proceedings Article | 3 March 2010 Paper

Visualizing of fs laser pulse induced micro-incisions inside crystalline lens tissue

O. Stachs, S. Schumacher, M. Kröger, H. Hoffmann, M. Fromm, A. Heisterkamp, H. Lubatschowski, R. Guthoff

Proceedings Volume 7550, 75500U (2010) https://doi.org/10.1117/12.841584

KEYWORDS: Optical fibers, Laser tissue interaction, Femtosecond phenomena, Visualization, Crystals, Confocal microscopy, Laser cutting, Tissues, Laser crystals, Microscopes

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Proceedings Article | 3 March 2010 Paper

Adaptive optics for the correction of eye aberrations

Anja Hansen, Mohammed Khattab, Raoul-Amadeus Lorbeer, Ronald Krueger, Holger Lubatschowski

Proceedings Volume 7550, 755012 (2010) https://doi.org/10.1117/12.840883

KEYWORDS: Wavefronts, Eye, Adaptive optics, Calibration, Femtosecond phenomena, Deformable mirrors, Retina, Laser tissue interaction, Laser damage threshold, Mirrors

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Proceedings Article | 3 March 2010 Paper

Three-dimensional multimodal microscopy of rabbit cornea after cross-linking treatment

A. Krüger, M. Hovakimyan, D. Ramírez, R.-A. Lorbeer, M. Kröger, O. Stachs, A. Wree, R. Guthoff, H. Lubatschowski, A. Heisterkamp

Proceedings Volume 7550, 755002 (2010) https://doi.org/10.1117/12.842282

KEYWORDS: Second-harmonic generation, Cornea, Confocal microscopy, Microscopy, Reflectivity, Collagen, Femtosecond phenomena, Visualization, Two photon excitation microscopy, Luminescence

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Proceedings Article | 25 February 2010 Paper

Fs-laser cell perforation using gold nanoparticles of different shapes

Markus Schomaker, Holger Fehlauer, Willem Bintig, Anaclet Ngezahayo, Ingo Nolte, Hugo Murua Escobar, Holger Lubatschowski, Alexander Heisterkamp

Proceedings Volume 7589, 75890C (2010) https://doi.org/10.1117/12.842446

KEYWORDS: Nanoparticles, Gold, Femtosecond phenomena, Particles, Molecules, Laser therapeutics, Spherical lenses, Green fluorescent protein, Stem cells, Multiphoton microscopy

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Proceedings Article | 24 February 2010 Paper

Applying optical Fourier filtering to standard optical projection tomography

Raoul-Amadeus Lorbeer, Heiko Meyer, Marko Heidrich, Holger Lubatschowski, Alexander Heisterkamp

Proceedings Volume 7570, 75700F (2010) https://doi.org/10.1117/12.841599

KEYWORDS: Modulation transfer functions, Bessel beams, Tomography, Projection systems, Optical tomography, Microscopy, Luminescence, Nerve, Optical filters, Image resolution

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Proceedings Article | 23 February 2010 Paper

Interaction dynamics of temporal and spatial separated cavitation bubbles in water

N. Tinne, T. Ripken, H. Lubatschowski

Proceedings Volume 7562, 75620O (2010) https://doi.org/10.1117/12.841285

KEYWORDS: Cavitation, Pulsed laser operation, Laser vision correction, Laser tissue interaction, Tissue optics, Laser cutting, Laser energy, Laser optics, Tissues, Laser systems engineering

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Proceedings Article | 20 February 2010 Paper

In vivo optical coherence tomography of percutaneous implants in hairless mice

S. Donner, F. Witte, I. Bartsch, F. Petraglia, O. Massow, M. Heidrich, H. Lubatschowski, A. Heisterkamp, A. Krüger

Proceedings Volume 7554, 75540S (2010) https://doi.org/10.1117/12.841640

KEYWORDS: Optical coherence tomography, Tissues, In vivo imaging, Interfaces, Skin, Inflammation, Tissue optics, Biopsy, Mirrors, Animal model studies

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Proceedings Article | 8 February 2010 Paper

Optical forces in biophotonics: transfection and cell sorting

Wolfgang Ertmer, Heiko Meyer, Raoul Lorbeer, Gerald Bergmann, Christina Krämer, Holger Lubatschowski, Hugo Murua Escoboar, Ingo Nolte, Alexander Heisterkamp

Proceedings Volume 7613, 76130Q (2010) https://doi.org/10.1117/12.841868

KEYWORDS: Microfluidics, Microscopes, Molecules, Luminescence, Biomedical optics, Ultrafast phenomena, Optical tweezers, Pulsed laser operation, Molecular lasers, Absorption

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SPIE Journal Paper | 1 September 2009 Open Access

Repetition rate dependency of reactive oxygen species formation during femtosecond laser-based cell surgery

Judith Baumgart, Kai Kuetemeyer, Willem Bintig, Anaclet Ngezahayo, Wolfgang Ertmer, Holger Lubatschowski, Alexander Heisterkamp

JBO, Vol. 14, Issue 05, 054040, (September 2009) https://doi.org/10.1117/12.10.1117/1.3253382

KEYWORDS: Luminescence, Molecules, Oxygen, Surgery, Femtosecond phenomena, Laser therapeutics, Laser irradiation, Pulsed laser operation, Laser vision correction, Multiphoton microscopy

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Proceedings Article | 17 July 2009 Paper

Femtosecond-lentotomy treatment: six-month follow-up of in vivo treated rabbit lenses

S. Schumacher, M. Fromm, U. Oberheide, P. Bock, I. Imbschweiler, H. Hoffmann, A. Beineke, G. Gerten, A. Wegener, H. Lubatschowski

Proceedings Volume 7373, 73730H (2009) https://doi.org/10.1117/12.831899

KEYWORDS: Retina, Optical coherence tomography, Lenses, Tissues, Surgery, Eye, Laser therapeutics, In vivo imaging, Crystals, Laser tissue interaction

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Presbyopia is an age related effect which affects every human at the age of about 40 years. So far reading glasses are the conventional treatment. According to Helmholtz' theory of accommodation one of the mayor reasons for the development of presbyopia is the increasing sclerosis of the lens. In contrast to that the ciliary muscle and the lens capsule remain mostly active and elastic the whole life. So a possible treatment could be the increase of the flexibility of the lens by creating gliding planes with fs-laser pulses inside the lens tissue. In former studies it was shown that fs-laser pulses were able to increase the flexibility of ex vivo porcine lenses as well as ex vivo human donor lenses. Our current aim was to evaluate the effect of the fs-laser pulses on the crystalline lens of living rabbit eyes due to the fs-lentotomy treatment. The main focus of the evaluation was the exclusion of possible side effects of the treatment like cataract formation or retina damage. The treated eyes were monitored using optical coherence tomography (OCT) and Scheimpflug imaging for localizing and studying the tissue effects of the incisions. Furthermore histological sections of the lens and retina were prepared. The rabbits were investigated pre operatively and up to six months post operatively. The fs-laser induced micro incisions were successfully applied to the left lens of each rabbit. The micro incisions within the crystalline lens were detectable with OCT and Scheimpflug imaging up to six month. The imaging within the lens showed a progressive fading of the incisional opacities generated by the femtosecond laser during the six months and no indication of cataract formation was found. OCT and Scheimpflug images emphasize themselves as necessary tools to monitor the micro incisions over time. Histopathological sections of the lens tissue support the findings of the non invasive imaging techniques. Also the histopathological sections of the retina show no thermal induced change due to the irradiation of the fs-pulses.

Proceedings Article | 17 July 2009 Paper

Nanoparticle mediated laser cell perforation

Markus Schomaker, Judith Baumgart, Anaclet Ngezahayo, Jörn Bullerdiek, Ingo Nolte, Hugo Murua-Escobar, Holger Lubatschowski, Alexander Heisterkamp

Proceedings Volume 7373, 737308 (2009) https://doi.org/10.1117/12.831903

KEYWORDS: Nanoparticles, Gold, Particles, Femtosecond phenomena, Molecules, Multiphoton microscopy, Laser therapeutics, Proteins, Laser marking, Stem cells

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Proceedings Article | 17 July 2009 Paper

Dynamic and interaction of fs-laser induced cavitation bubbles for analyzing the cutting effect

N. Tinne, S. Schumacher, V. Nuzzo, T. Ripken, H. Lubatschowski

Proceedings Volume 7373, 73730L (2009) https://doi.org/10.1117/12.831896

KEYWORDS: Cavitation, Laser vision correction, Laser cutting, Laser tissue interaction, Pulsed laser operation, Tissue optics, Laser energy, Laser optics, Laser systems engineering, Biological research

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Proceedings Article | 14 July 2009 Paper

A laryngoscope for office-based imaging of human vocal folds using OCT

H. Wisweh, N. Rohrbeck, A. Krüger, M. Kraft, K. Aleksandrov, H. Lubatschowski

Proceedings Volume 7372, 73720I (2009) https://doi.org/10.1117/12.831820

KEYWORDS: Optical coherence tomography, Tissues, Video, Imaging systems, Motion measurement, Neck, Doppler effect, Laser development, Motion analysis, Light sources

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SPIE Journal Paper | 1 July 2009 Open Access

Green laser light activates the inner ear

G. Wenzel, S. Balster, K. Zhang, H. Lim, U. Reich, Ole Massow, Holger Lubatschowski, Wolfgang Ertmer, T. Lenarz, G. Reuter

JBO, Vol. 14, Issue 04, 044007, (July 2009) https://doi.org/10.1117/12.10.1117/1.3174389

KEYWORDS: Ear, Acoustics, Optical fibers, Sensors, Nerve, Pulsed laser operation, Electrodes, Visible radiation, Laser tissue interaction, Biomedical optics

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Proceedings Article | 25 February 2009 Paper

OCT-aided femtosecond laser micromachining device

Ole Massow, Michael Jackstadt, Henning Wisweh, Fabian Will, Holger Lubatschowski

Proceedings Volume 7203, 720307 (2009) https://doi.org/10.1117/12.808754

KEYWORDS: Optical coherence tomography, Tissues, Cornea, Scattering, Imaging systems, Laser cutting, Image resolution, Tissue optics, Objectives, Surgery

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Proceedings Article | 23 February 2009 Paper

Stimulation of the cochlea using green laser light

G. Wenzel, S. Balster, H. Lim, K. Zhang, U. Reich, H. Lubatschowski, W. Ertmer, T. Lenarz, G. Reuter

Proceedings Volume 7161, 71611Z (2009) https://doi.org/10.1117/12.817049

KEYWORDS: Ear, Optical fibers, Sensors, Acoustics, Nerve, Pulsed laser operation, Laser tissue interaction, Fiber lasers, Thermal effects, Scanning probe lithography

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The success of conventional hearing aids and electrical cochlear implants have generally been limited to hearing in quiet situations, in part due to a lack of localized (i.e., frequency specificity) sensorineural activation and subsequent impaired speech discrimination in noise. Laser light is a source of energy that can be focused in a controlled manner and may provide more localized activation of the inner ear, the cochlea. Compound action potentials have been elicited using 2.12 µm laser pulses through activation of auditory nerve fibers (Izzo et al. 2006). Laser stimulation (813 nm) of the cochlea has shown to induce basilar membrane motion and cochlear microphonic potentials (Fridberger et al. 2006). We sought to assess if visible light (green, 532 nm, 10 ns pulses) could be used to consistently activate the cochlea. The laser parameters were selected based on our initial attempt to induce an optoacoustic effect as the energy transfer mechanism to the cochlea. Click evoked auditory brainstem responses (AABRs) were recorded preoperatively in ketamine-anesthetized guinea pigs to confirm normal hearing. The bulla and then the cochlea were exposed. Optically evoked ABRs (OABR) were recorded in response to laser stimulation with a 50 µm optical fiber (532 nm, 10 ns pulses, 500 repetitions, 10 pulses/s; Nd:YAG laser) at the round window (RW) directed towards the basilar membrane (BM). OABRs similar in morphology to acoustically evoked ABRs, except for shorter latencies, were obtained for stimulation through the RW with energy levels between 1.7-30 µJ/pulse. The OABRs increased with increasing energy level reaching a saturation level around 13-15 µJ/pulse. Furthermore the responses remained consistent across stimulation over time, including stimulation at 13 µJ/pulse for over 30 minutes, indicating minimal or no damage within the cochlea with this type of laser stimulation. Overall we have demonstrated that laser light stimulation with 532 nm has potential for a new type of auditory prosthesis that can activate the cochlea without any apparent functional damage. Further studies are needed to determine the optimal laser parameters and fiber placement locations for localized and tonotopic activation.

Proceedings Article | 18 February 2009 Paper

Plasmonic perforation of living cells using ultrashort laser pulses and gold nanoparticles

Markus Schomaker, Judith Baumgart, Anaclet Ngezahayo, Jörn Bullerdiek, Ingo Nolte, Hugo Murua Escobar, Holger Lubatschowski, Alexander Heisterkamp

Proceedings Volume 7192, 71920U (2009) https://doi.org/10.1117/12.809316

KEYWORDS: Nanoparticles, Gold, Particles, Proteins, Plasmons, Femtosecond phenomena, Green fluorescent protein, Luminescence, Plasmonics, Ultrafast phenomena

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Proceedings Article | 20 February 2008 Paper

Investigation of reactive oxygen species formation in living cells during femtosecond laser based cell surgery

J. Baumgart, W. Bintig, A. Ngezahayo, W. Ertmer, H. Lubatschowski, A. Heisterkamp

Proceedings Volume 6854, 68540O (2008) https://doi.org/10.1117/12.763315

KEYWORDS: Luminescence, Surgery, Oxygen, Femtosecond phenomena, Laser therapeutics, Pulsed laser operation, Laser irradiation, Molecular lasers, Laser energy, Laser vision correction

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Proceedings Article | 15 February 2008 Paper

Femtosecond laser microsurgery system controlled by optical coherence tomography

Ole Massow, Fabian Will, Holger Lubatschowski

Proceedings Volume 6881, 688106 (2008) https://doi.org/10.1117/12.761714

KEYWORDS: Optical coherence tomography, Tissues, Femtosecond phenomena, Laser cutting, Imaging systems, Surgery, Laser systems engineering, Video, Tissue optics, Scattering

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Proceedings Article | 15 February 2008 Paper

Numerical modeling of nonlinear plasma formation in high-NA micromachining of transparent materials and biological cells using ultrashort laser pulses

C. Arnold, A. Heisterkamp, W. Ertmer, H. Lubatschowski

Proceedings Volume 6881, 688104 (2008) https://doi.org/10.1117/12.761206

KEYWORDS: Plasma, Ultrafast phenomena, Plasma generation, Ionization, Electrons, Nonlinear optics, Absorption, Surgery, Soft tissue optics, Tissue optics

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Ultrashort laser pulses recently found extensive application in micro- and nanostructuring, in refractive surgery of the eye, and in biophotonics. Due to the high laser intensity required to induce optical breakdown, nonlinear plasma formation is generally accompanied by a number of undesired nonlinear side-effects such as self-focusing, filamentation and plasma-defocusing, seriously limiting achievable precision and reproducibility. To reduce pulse energy, enhance precision, and limit nonlinear side effects, applications of ultrashort pulses have recently evolved towards tight focusing using high numerical aperture microscope objectives. However, from the theoretical and numerical point of view generation of optical breakdown at high numerical aperture focusing was barely studied. To simulate the interaction of ultrashort laser pulses with transparent materials, a comprehensive numerical model taking into account nonlinear propagation, plasma generation as well as the pulse's interaction with the generated plasma is introduced. By omitting the widely used scalar and paraxial approximations a novel nonlinear propagation equation is derived, especially suited to meet the conditions of high numerical aperture focusing. The multiple rate equation (MRE) model is used to simultaneously calculate the generation of free electrons. Nonparaxial and vectorial diffraction theory provides initial conditions. The theoretical model derived is applied to numerically study the generation of optical breakdown plasmas, concentrating on parameters usually found in experimental applications of cell surgery. Water is used as a model substance for biological soft tissue and cellular constituents. For focusing conditions of numerical aperture NA < 0.9 generation of optical breakdown is shown to be strongly influenced by plasma defocusing, resulting in spatially distorted breakdown plasmas of expanded size. For focusing conditions of numerical aperture NA ≥ 0.9 on the other hand generation of optical breakdown is found to be almost unaffected by distortive side-effects, perfectly suited for material manipulation of highest precision.

Proceedings Article | 11 February 2008 Paper

Fs-lentotomy: first in vivo studies on rabbit eyes with a 100 kHz laser system

S. Schumacher, U. Oberheide, M. Fromm, W. Ertmer, G. Gerten, A. Wegener, H. Lubatschowski

Proceedings Volume 6844, 68440V (2008) https://doi.org/10.1117/12.759132

KEYWORDS: Laser cutting, Laser therapeutics, Optical coherence tomography, Laser tissue interaction, Eye, Femtosecond phenomena, Laser vision correction, Laser systems engineering, In vivo imaging, Cornea

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Proceedings Article | 8 February 2008 Paper

Significance of optical coherence tomography in the assessment of laryngeal lesions

Marcel Kraft, Susanne von Gerlach, Kathrin Alexandrov, Henning Wisweh, Holger Lubatschowski, Hiltrud Glanz, Christoph Arens

Proceedings Volume 6842, 68421O (2008) https://doi.org/10.1117/12.772822

KEYWORDS: Optical coherence tomography, Diagnostics, Cancer, Scattering, Surgery, Spatial resolution, Biopsy, Translucency, Tumors, Tissue optics

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Proceedings Article | 13 July 2007 Paper

Optical coherence tomography monitoring of vocal fold femtosecond laser microsurgery

Henning Wisweh, Ulrich Merkel, Ann-Kristin Hüller, Kathrin Lüerßen, Holger Lubatschowski

Proceedings Volume 6632, 663207 (2007) https://doi.org/10.1117/12.728139

KEYWORDS: Optical coherence tomography, Tissues, Laser therapeutics, Laser tissue interaction, Laser ablation, Laser cutting, Femtosecond phenomena, Microsurgery, Surgery, Tissue optics

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Proceedings Article | 13 July 2007 Paper

fs-Lentotomie: changing the accommodation amplitude of presbyopic human crystalline lenses by fs laser pulses

S. Schumacher, U. Oberheide, H. Theuer, M. Fromm, T. Ripken, G. Gerten, W. Ertmer, H. Lubatschowski

Proceedings Volume 6632, 66321G (2007) https://doi.org/10.1117/12.728197

KEYWORDS: Lenses, Laser therapeutics, Crystals, 3D modeling, Data modeling, Laser cutting, Tissues, Femtosecond phenomena, Finite element methods, Laser crystals

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Proceedings Article | 11 July 2007 Paper

Optical coherence tomography controlled femtosecond laser microsurgery system

Ole Massow, Fabian Will, Holger Lubatschowski

Proceedings Volume 6627, 662717 (2007) https://doi.org/10.1117/12.728348

KEYWORDS: Optical coherence tomography, Laser cutting, Femtosecond phenomena, Tissues, Imaging systems, Microscopes, Surgery, Laser systems engineering, Cameras, Polymethylmethacrylate

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Proceedings Article | 23 March 2007 Paper

Optical characterization of vocal folds by OCT-based laryngoscopy

Kathrin Lueerssen, Henning Wisweh, Martin Ptok, Holger Lubatschowski

Proceedings Volume 6424, 64241O (2007) https://doi.org/10.1117/12.699539

KEYWORDS: Optical coherence tomography, Tissues, Diagnostics, Imaging systems, Tissue optics, In vivo imaging, Optical fibers, Microsurgery, Laser tissue interaction, Vibration simulation

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Proceedings Article | 13 March 2007 Paper

Modeling of ultrashort pulse propagation and nonlinear plasma formation in transparent Kerr media using realistic initial conditions

C. Arnold, W. Ertmer, H. Lubatschowski

Proceedings Volume 6460, 646010 (2007) https://doi.org/10.1117/12.698934

KEYWORDS: Plasma, Electrons, Ionization, Ultrafast phenomena, Plasma generation, Wave propagation, Diffraction, Refractive index, Polarization, Objectives

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Ultrashort laser pulses tightly focused provide intensity sufficient to initialize nonlinear ionization processes. Thus a plasma is generated in the focal region eventually resulting in optical breakdown. The deterministic character of this nonlinear interaction enables the generation of precise and highly reproducible material alteration. To gain better spatial precision applications have recently evolved strongly towards tight focusing of ultrashort pulses using microscope objectives as focusing units. The pulse energy required to generate optical breakdown was thus reduced to nanojoules or even below. The mechanical effects subsequent to plasma generation can be minimized to the very focus. Cell surgery with ultrashort pulses enables to precisely ablate cell organelles without observable hazardous effects to the surroundings or the entire cell. To numerically investigate the nonlinear interaction of ultrashort pulses with transparent media, a model including both nonlinear pulse propagation and plasma generation is introduced. The numerical code is based on a (3+1)-dimensional nonlinear Schrödinger equation describing the pulse propagation and the interaction with the density of free electrons that are generated in the focus. The nonlinear wave equation was derived taking into account both nonparaxial and vectorial effects to accurately include tight focusing at high numerical aperture. A multi rate equation model for dielectrics recently published by B. Rethfeld is used to simultaneously calculate the generation of free electrons. Numerical calculations based on this model are used to understand the dependence between size, geometry and density of optical breakdown plasmas in various focusing geometries of high numerical aperture. The code enables to use arbitrary initial conditions for the laser field in the focus. At high numerical aperture it is most important to start the simulation using realistic initial conditions. Especially the vectorial character of the electric field is most important to be considered. Thus a vectorial diffraction integral was used to calculate initial conditions at high numerical aperture. The code is applicable to any transparent Kerr medium, whose linear and nonlinear optical parameters are known. Within this work the code was applied to water as a model substance to biological soft tissue and cellular constituents.

Proceedings Article | 13 March 2007 Paper

Laser microtome: all optical preparation of thin tissue samples

Fabian Will, Thomas Block, Peggy Menne, Holger Lubatschowski

Proceedings Volume 6460, 646007 (2007) https://doi.org/10.1117/12.713905

KEYWORDS: Tissues, Laser tissue interaction, Laser cutting, Lung, Cartilage, Cornea, Kidney, Light scattering, Glasses, Heart

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Proceedings Article | 5 March 2007 Paper

Fs-laser induced flexibility increase in the crystalline lens

S. Schumacher, M. Fromm, R. Lakharia, M. Schaefer, U. Oberheide, T. Ripken, P. Breitenfeld, G. Gerten, W. Ertmer, H. Lubatschowksi

Proceedings Volume 6426, 64261C (2007) https://doi.org/10.1117/12.700148

KEYWORDS: Laser therapeutics, 3D modeling, Crystals, Laser cutting, Tissues, Finite element methods, Data modeling, Optical fibers, Glasses, Laser crystals

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Proceedings Article | 6 February 2007 Paper

Live cell opto-injection by femtosecond laser pulses

J. Baumgart, W. Bintig, W. Ertmer, H. Lubatschowski, A. Heisterkamp

Proceedings Volume 6435, 643512 (2007) https://doi.org/10.1117/12.700166

KEYWORDS: Luminescence, Femtosecond phenomena, Proteins, Microscopes, Fluorescent proteins, Microscopy, Green fluorescent protein, Viruses, Cell death, Tissues

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Proceedings Article | 7 March 2006 Paper

FEM simulation of the human lens compared to ex vivo porcine lens cutting pattern: a possible treatment of presbyopia

T. Ripken, P. Breitenfeld, M. Fromm, U. Oberheide, G. Gerten, H. Lubatschowski

Proceedings Volume 6138, 613819 (2006) https://doi.org/10.1117/12.646635

KEYWORDS: Tissues, Finite element methods, Tissue optics, Laser cutting, Eye, Cornea, Optical fibers, Data modeling, Eye models, Natural surfaces

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Proceedings Article | 7 March 2006 Paper

Investigation of possible fs-LASIK induced retinal damage

S. Schumacher, M. Sander, A. Stolte, C. Doepke, W. Baumgaertner, H. Lubatschowski

Proceedings Volume 6138, 61381I (2006) https://doi.org/10.1117/12.645147

KEYWORDS: Retina, Laser damage threshold, Eye, Cornea, Laser cutting, Laser tissue interaction, Laser systems engineering, Continuous wave operation, Femtosecond phenomena, Laser vision correction

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Proceedings Article | 28 February 2006 Paper

Simulation of ultrashort pulse induced plasma generation and interaction within the bulk of transparent Kerr media

C. Arnold, W. Ertmer, H. Lubatschowski

Proceedings Volume 6108, 610808 (2006) https://doi.org/10.1117/12.645637

KEYWORDS: Electrons, Plasma, Ionization, Ultrafast phenomena, Plasma generation, Gaussian beams, Tissue optics, Refractive index, Pulsed laser operation, Tissues

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Proceedings Article | 28 February 2006 Paper

Multiphoton microscopy for cell surgery

J. Baumgart, A. Heisterkamp, A. Ngezahayo, W. Ertmer, H. Lubatschowski

Proceedings Volume 6108, 61081B (2006) https://doi.org/10.1117/12.645699

KEYWORDS: Luminescence, Retina, Absorption, Multiphoton microscopy, Tissues, Tissue optics, Surgery, Femtosecond phenomena, Eye, Laser ablation

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Proceedings Article | 22 February 2006 Paper

Optical characterization of vocal folds using OCT

Kathrin Lüerßen, Holger Lubatschowski, Nicole Radicke, Martin Ptok

Proceedings Volume 6078, 60781O (2006) https://doi.org/10.1117/12.645144

KEYWORDS: Optical coherence tomography, Tissue optics, Tissues, In vivo imaging, Diagnostics, Beam splitters, Laser tissue interaction, Real time imaging, Light scattering, Ultrasonography

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Proceedings Article | 27 August 2005 Paper

Finite element method-simulation of the human lens during accommodation

P. Breitenfeld, T. Ripken, H. Lubatschowski

Proceedings Volume 5863, 586302 (2005) https://doi.org/10.1117/12.633086

KEYWORDS: Ray tracing, Tissues, Data modeling, Eye, Cornea, Eye models, Geometrical optics, Tissue optics, Finite element methods, 3D modeling

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Proceedings Article | 25 April 2005 Paper

Optical characterization of vocal folds with optical coherence tomography

Kathrin Luerssen, Holger Lubatschowski, Hagen Gasse, Rudiger Koch, Martin Ptok

Proceedings Volume 5686, (2005) https://doi.org/10.1117/12.592630

KEYWORDS: Optical coherence tomography, Tissues, Tissue optics, Diagnostics, Optical fibers, Beam splitters, Light sources, Image resolution, Biological research, Laser tissue interaction

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Proceedings Article | 18 April 2005 Paper

Fs-laser induced elasticity changes to improve presbyopic lens accommodation

Tammo Ripken, Uwe Oberheide, Cerstin Ziltz, Georg Gerten, Holger Lubatschowski

Proceedings Volume 5688, (2005) https://doi.org/10.1117/12.588242

KEYWORDS: Laser cutting, Laser optics, Tissues, Laser tissue interaction, Femtosecond phenomena, Tissue optics, Ultrafast phenomena, Scanners, Glasses, Eye

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Proceedings Article | 18 April 2005 Paper

Investigation of retinal damage during refractive eye surgery

Silvia Schumacher, Meike Sander, Carola Döpke, Andrea Gröne, Wolfgang Ertmer, Holger Lubatschowski

Proceedings Volume 5688, (2005) https://doi.org/10.1117/12.588938

KEYWORDS: Eye, Retina, Tissues, Temperature metrology, Cornea, Surgery, Laser vision correction, Laser cutting, Laser damage threshold, Tissue optics

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Proceedings Article | 21 March 2005 Paper

Numerical calculation of nonlinear ultrashort laser pulse propagation in transparent Kerr media

Cord Arnold, Alexander Heisterkamp, Wolfgang Ertmer, Holger Lubatschowski

Proceedings Volume 5714, (2005) https://doi.org/10.1117/12.588903

KEYWORDS: Electrons, Ionization, Plasma, Tissue optics, Ultrafast phenomena, Refractive index, Absorption, Cornea, Plasma generation, Water

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Proceedings Article | 13 July 2004 Paper

Investigations for the correction of presbyopia by-fs-laser induced cuts

Tammo Ripken, Uwe Oberheide, Alexander Heisterkamp, Wolfgang Ertmer, Georg Gerten, Holger Lubatschowski

Proceedings Volume 5314, (2004) https://doi.org/10.1117/12.528955

KEYWORDS: Laser cutting, Tissues, Laser tissue interaction, Femtosecond phenomena, Eye, Cornea, Tissue optics, Glasses, Light scattering, Scanners

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Proceedings Article | 1 June 2004 Paper

Numerical calculation of nonlinear ultrashort laser pulse propagation in water

Cord Arnold, Alexander Heisterkamp, Wolfgang Ertmer, Holger Lubatschowski

Proceedings Volume 5340, (2004) https://doi.org/10.1117/12.529003

KEYWORDS: Electrons, Tissue optics, Ultrafast phenomena, Ionization, Cornea, Water, Refractive index, Diffraction, Plasma, Dispersion

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Proceedings Article | 18 November 2003 Paper

Processing HIP-zirconia with ultra-short laser pulses

Kristian Werelius, Paul Weigl, Holger Lubatschowski

Proceedings Volume 5063, (2003) https://doi.org/10.1117/12.540505

KEYWORDS: Pulsed laser operation, Laser ablation, Laser processing, Zirconium dioxide, Ceramics, Picosecond phenomena, Manufacturing, Laser systems engineering, 3D microstructuring, Energy efficiency

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Proceedings Article | 16 October 2003 Paper

Extraluminal laser angioplasty (ELAN): laser tissue removal of arterial wall for restoration of wall flexibility and methods for therapy control

Fabian Will, Ajoy Singh, Evgeny Sharabrin, Veronika Sapozhnikova, Roman Kuranov, Wolfgang Ertmer, Holger Lubatschowski

Proceedings Volume 5142, (2003) https://doi.org/10.1117/12.500598

KEYWORDS: Arteries, Laser therapeutics, Optical coherence tomography, Tissues, Diffusion, Blood, Spectroscopy, Laser ablation, Laser tissue interaction, Light scattering

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Proceedings Article | 16 October 2003 Paper

First in-vivo studies of presbyopia treatment with ultrashort laser pulses

Tammo Ripken, Alexander Heisterkamp, Uwe Oberheide, Ron Krueger, Elke Luetkefels, Wolfgang Drommer, Wolfgang Ertmer, Holger Lubatschowski

Proceedings Volume 5142, (2003) https://doi.org/10.1117/12.500421

KEYWORDS: Laser cutting, Eye, In vivo imaging, Cornea, Tissue optics, Laser tissue interaction, Femtosecond phenomena, Optical fibers, Laser therapeutics, Tissues

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Proceedings Article | 16 October 2003 Paper

Applications of ultrafast lasers in ophthalmology

Alexander Heisterkamp, Tammo Ripken, Uwe Oberheide, Omid Kermani, Thanongsak Mamom, Wolfgang Drommer, Wolfgang Ertmer, Holger Lubatschowski

Proceedings Volume 5142, (2003) https://doi.org/10.1117/12.500612

KEYWORDS: Eye, Cornea, Surgery, Laser cutting, Tissues, Laser vision correction, Laser therapeutics, Ultrafast lasers, Ophthalmology, Wound healing

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Proceedings Article | 12 September 2003 Paper

Extraluminal laser angioplasty (ELAN): a new method for treating atherosclerotic vessels

Fabian Will, Ajoy Singh, Wolfgang Ertmer, Herbert Welling, Holger Lubatschowski

Proceedings Volume 4949, (2003) https://doi.org/10.1117/12.476269

KEYWORDS: Arteries, Tissues, Laser therapeutics, Laser cutting, Transducers, Time metrology, Surgery, Blood circulation, Optical coherence tomography, Signal detection

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Proceedings Article | 17 June 2003 Paper

3 μm diode-pumped solid state erbium laser for cataract surgery

Holger Ernst, Wolfgang Ertmer, Holger Lubatschowski

Proceedings Volume 4968, (2003) https://doi.org/10.1117/12.478260

KEYWORDS: Laser systems engineering, Semiconductor lasers, Erbium lasers, Er:YAG lasers, Surgery, Crystals, Laser crystals, Laser therapeutics, Laser development, Lenses

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SPIE Journal Paper | 1 April 2003 Open Access

Optoacoustic imaging for optimization of laser cyclophotocoagulation

Uwe Oberheide, Ingo Bruder, Herbert Welling, Wolfgang Ertmer, Holger Lubatschowski

JBO, Vol. 8, Issue 02, (April 2003) https://doi.org/10.1117/12.10.1117/1.1559998

KEYWORDS: Sensors, Tissues, Tissue optics, Signal detection, Eye, Sclera, Absorption, Laser tissue interaction, Optical properties, Ultrasonography

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Proceedings Article | 19 February 2003 Paper

Medical and biological applications for ultrafast laser pulses

Holger Lubatschowski, Alexander Heisterkamp, Fabian Will, Ajoy Singh, Jesper Serbin, Andreas Ostendorf, Omid Kermani, R. Heermann, Herbert Welling, Wolfgang Ertmer

Proceedings Volume 4830, (2003) https://doi.org/10.1117/12.486505

KEYWORDS: Laser tissue interaction, Tissues, Laser ablation, Femtosecond phenomena, Laser dentistry, Cornea, Pulsed laser operation, Laser vision correction, Surgery, Laser cutting

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Proceedings Article | 13 June 2002 Paper

Therapy monitoring of laser cyclophotocoagulation

Uwe Oberheide, Christoph Lee, Ronald Krebs, Herbert Welling, Wolfgang Ertmer, Holger Lubatschowski

Proceedings Volume 4611, (2002) https://doi.org/10.1117/12.470605

KEYWORDS: Laser therapeutics, Sensors, Absorption, Tissues, Optical properties, Signal processing, Semiconductor lasers, Tissue optics, Scattering, Ultrasonography

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Proceedings Article | 13 June 2002 Paper

Intrastromal refractive sugery with ultrashort laser pulses in living animals

Alexander Heisterkamp, Thanongsak Mamom, Omid Kermani, Wolfgang Drommer, Herbert Welling, Wolfgang Ertmer, Holger Lubatschowski

Proceedings Volume 4611, (2002) https://doi.org/10.1117/12.470587

KEYWORDS: Surgery, Eye, Cornea, Ultrafast phenomena, Pulsed laser operation, Laser therapeutics, Laser cutting, Tissues, Laser vision correction, Thermal effects

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Proceedings Article | 10 June 2002 Paper

Investigation of optical properties of human skin in the UV

Ronald Krebs, Merve Meinhardt, Uwe Oberheide, Holger Lubatschowski, Angelika Anders

Proceedings Volume 4618, (2002) https://doi.org/10.1117/12.469863

KEYWORDS: Skin, Optical properties, Sensors, In vivo imaging, Acoustics, Ultrasonics, Ultraviolet radiation, Tissues, Signal attenuation, Absorption

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Proceedings Article | 10 June 2002 Paper

Two-dimensional detection of optoacoustic stress transients

Uwe Oberheide, Christoph Lee, Ronald Krebs, Herbert Welling, Wolfgang Ertmer, Holger Lubatschowski

Proceedings Volume 4618, (2002) https://doi.org/10.1117/12.469853

KEYWORDS: Sensors, Metals, Biomedical optics, Tissues, Detector arrays, Ultrasonography, Aluminum, Tomography, Profiling, Tissue optics

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Proceedings Article | 1 April 2002 Paper

Ultrafast laser pulses for medical applications

Holger Lubatschowski, Alexander Heisterkamp, Fabian Will, Jesper Serbin, Thorsten Bauer, Carsten Fallnich, Herbert Welling, Wiebke Mueller, Burkard Schwab, Ajoy Singh, Wolfgang Ertmer

Proceedings Volume 4633, (2002) https://doi.org/10.1117/12.461386

KEYWORDS: Pulsed laser operation, Tissues, Laser tissue interaction, Laser ablation, Laser dentistry, Femtosecond phenomena, Cornea, Surgery, Laser cutting, Laser therapeutics

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Proceedings Article | 26 October 2001 Paper

Nonlinear effects inside corneal tissue after fs-photodisruption

Alexander Heisterkamp, Tammo Ripken, Holger Lubatschowski, Herbert Welling, Wolfgang Drommer, Elke Luetkefels, Thanongsak Mamom, Wolfgang Ertmer

Proceedings Volume 4433, (2001) https://doi.org/10.1117/12.446501

KEYWORDS: Cornea, Pulsed laser operation, Laser therapeutics, Surgery, Eye, Tissues, Laser cutting, Laser vision correction, Sensors, Optical filters

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Proceedings Article | 24 October 2001 Paper

Optoacoustic imaging for ophthalmology

Uwe Oberheide, Birte Jansen, Ingo Bruder, Holger Lubatschowski, Herbert Welling, Wolfgang Ertmer

Proceedings Volume 4434, (2001) https://doi.org/10.1117/12.446668

KEYWORDS: Absorption, Tissue optics, Eye, Signal detection, Optical properties, Ultrasonography, Biomedical optics, Sensors, Ophthalmology, Semiconductor lasers

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Proceedings Article | 15 June 2001 Paper

Optoacoustic online control for laser cyclophotocoagulation

Uwe Oberheide, Birte Jansen, Ingo Bruder, Holger Lubatschowski, Herbert Welling, Wolfgang Ertmer

Proceedings Volume 4256, (2001) https://doi.org/10.1117/12.429321

KEYWORDS: Semiconductor lasers, Sclera, Signal generators, Sensors, Eye, Photodiodes, Absorption, Optical properties, Tissues, Signal attenuation

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Proceedings Article | 7 June 2001 Paper

Optimization of the parameters for intrastromal refractive surgery with ultrashort laser pulses

Alexander Heisterkamp, Tammo Ripken, Holger Lubatschowski, Herbert Welling, Wolfgang Dommer, Elke Luetkefels, Thanongsak Mamom, Wolfgang Ertmer

Proceedings Volume 4245, (2001) https://doi.org/10.1117/12.429279

KEYWORDS: Laser vision correction, Cornea, Surgery, Pulsed laser operation, Laser cutting, Eye, Laser therapeutics, Tissue optics, Ultrafast phenomena, Laser tissue interaction

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SPIE Journal Paper | 1 April 2001 Open Access

Pulsed photothermal radiometry as a method for investigating blood vessel-like structures

Christoph Schmitz, Uwe Oberheide, Stefan Lohmann, Holger Lubatschowski, Wolfgang Ertmer

JBO, Vol. 6, Issue 02, (April 2001) https://doi.org/10.1117/12.10.1117/1.1344193

KEYWORDS: Absorption, Capillaries, Blood vessels, Radiometry, Blood, Optical properties, Temperature metrology, Tissues, Diffusion, Sensors

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Proceedings Article | 16 November 2000 Paper

Intrastromal cutting effects in rabbit cornea using femtosecond laser pulses

Alexander Heisterkamp, Tammo Ripken, Holger Lubatschowski, Herbert Welling, Elke Luetkefels, Wolfgang Drommer, Wolfgang Ertmer

Proceedings Volume 4161, (2000) https://doi.org/10.1117/12.409337

KEYWORDS: Cavitation, Tissue optics, Laser cutting, Cornea, Pulsed laser operation, Tissues, Eye, Femtosecond phenomena, Photography, Laser optics

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Proceedings Article | 16 November 2000 Paper

Optoacoustical tissue differentiation for on-line therapy control

Uwe Oberheide, Birte Jansen, Ingo Bruder, Holger Lubatschowski, Herbert Welling, Wolfgang Ertmer

Proceedings Volume 4161, (2000) https://doi.org/10.1117/12.409333

KEYWORDS: Sensors, Signal detection, Tissue optics, Reflection, Absorption, Sclera, Laser therapeutics, Tissues, Picosecond phenomena, Semiconductor lasers

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Proceedings Article | 7 June 2000 Paper

Optoacoustic tomography as a diagnostic tool for transscleral laser cyclophotocoagulation

Uwe Oberheide, Arne Buesching, Ingo Bruder, Holger Lubatschowski, Herbert Welling, Wolfgang Ertmer

Proceedings Volume 3908, (2000) https://doi.org/10.1117/12.387511

KEYWORDS: Sclera, Sensors, Tomography, Laser therapeutics, Diagnostics, Semiconductor lasers, Tissue optics, Signal attenuation, Monte Carlo methods, Picosecond phenomena

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Proceedings Article | 7 June 2000 Paper

Intrastromal refractive surgery by ultrashort laser pulses: side effects and mechanisms

Alexander Heisterkamp, Gero Maatz, Tammo Ripken, Holger Lubatschowski, Herbert Welling, Elke Luetkefels, Wolfgang Drommer, Wolfgang Ertmer

Proceedings Volume 3908, (2000) https://doi.org/10.1117/12.387518

KEYWORDS: Laser therapeutics, Cavitation, Cornea, Pulsed laser operation, Hydrogen, Surgery, Laser vision correction, Picosecond phenomena, Ultrafast phenomena, Scanning electron microscopy

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Proceedings Article | 13 May 1998 Paper

Characterization of tissue processing with a continuous-wave Tm:YAG laser at 2.06-um wavelength

Holger Lubatschowski, Michael Fiebig, P. Fuhrberg, Heinrich Teichmann, Herbert Welling

Proceedings Volume 3254, (1998) https://doi.org/10.1117/12.308171

KEYWORDS: Laser tissue interaction, Fiber lasers, Laser ablation, Tissues, Heart, Continuous wave operation, Liver, Laser energy, Energy efficiency, Laser processing

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Proceedings Article | 14 January 1998 Paper

Pulsed photothermal radiometric investigations of absorbing and scattering media

Christoph Schmitz, Uwe Oberheide, Stefan Lohmann, Holger Lubatschowski, Wolfgang Ertmer

Proceedings Volume 3195, (1998) https://doi.org/10.1117/12.297882

KEYWORDS: Diffusion, Light scattering, Scattering media, Monte Carlo methods, Optical properties, Tissue optics, Detection theory, Scattering, Spectroscopy, Absorption

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Proceedings Article | 14 January 1998 Paper

Characterization of tissuelike media using the photoacoustic method

Stefan Lohmann, Michael Zacher, Christoph Schmitz, Holger Lubatschowski, Wolfgang Ertmer

Proceedings Volume 3195, (1998) https://doi.org/10.1117/12.297880

KEYWORDS: Signal detection, Transducers, Photoacoustic spectroscopy, Acoustics, Tissue optics, Optical properties, Diffraction, Pulsed laser operation, Absorption, Diffusion

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Proceedings Article | 14 January 1998 Paper

Modeling and numerical simulation of the infrared photoablation process

Andreas Olmes, M. Brand, M. Raible, Holger Lubatschowski, Wolfgang Ertmer, E. Baensch, G. Dziuk

Proceedings Volume 3195, (1998) https://doi.org/10.1117/12.297904

KEYWORDS: Tissues, Laser tissue interaction, Absorption, Infrared lasers, Tissue optics, Infrared radiation, Thermal modeling, Process modeling, Temperature metrology, Natural surfaces

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Proceedings Article | 22 December 1997 Paper

Photoablation of the cornea with a Q-switched Er:YAG laser

Holger Lubatschowski, U. Hetzel, Omid Kermani, Carsten Ziolek, Wolfgang Drommer, Wolfgang Ertmer

Proceedings Volume 3192, (1997) https://doi.org/10.1117/12.297839

KEYWORDS: Cornea, Er:YAG lasers, Q switched lasers, Laser ablation, Wound healing, Pulsed laser operation, Laser therapeutics, Electron microscopy, Laser tissue interaction, Excimer lasers

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Proceedings Article | 5 December 1996 Paper

Photoacoustic determination of optical parameters of biological tissue

Stefan Lohmann, Christine Ruff, Christoph Schmitz, Holger Lubatschowski, Wolfgang Ertmer

Proceedings Volume 2923, (1996) https://doi.org/10.1117/12.260727

KEYWORDS: Tissue optics, Photoacoustic spectroscopy, Signal detection, Acoustics, Pulsed laser operation, Transducers, Signal processing, Signal attenuation, Near field optics, Optical properties

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Proceedings Article | 5 December 1996 Paper

Erbium laser photoablation of the cornea

Holger Lubatschowski, A. Hoegele, Stefan Lohmann, Andreas Olmes, Wolfgang Ertmer

Proceedings Volume 2930, (1996) https://doi.org/10.1117/12.260857

KEYWORDS: Erbium lasers, Laser ablation, Laser tissue interaction, Pulsed laser operation, Cornea, Q switched lasers, Acoustics, Er:YAG lasers, Water, Surgery

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Proceedings Article | 5 December 1996 Paper

Pulsed photothermal radiometric investigations of optical and thermal properties

Christoph Schmitz, Thomas Hantzko, Stefan Lohmann, Holger Lubatschowski, Wolfgang Ertmer

Proceedings Volume 2923, (1996) https://doi.org/10.1117/12.260735

KEYWORDS: Tissue optics, Thermography, Radio optics, Optical properties, Diffusion, Geometrical optics, Laser tissue interaction, Absorption, Absorbance, Radiometry

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Proceedings Article | 5 December 1996 Paper

Numerical simulation of infrared photoablation

Andreas Olmes, H.-G. Franke, M. Raible, Holger Lubatschowski, Wolfgang Ertmer, E. Baensch, G. Dziuk

Proceedings Volume 2923, (1996) https://doi.org/10.1117/12.260734

KEYWORDS: Absorption, Laser ablation, Tissues, Tissue optics, Laser tissue interaction, Diffusion, Infrared radiation, Numerical simulations, Temperature metrology, Infrared photography

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Proceedings Article | 10 January 1996 Paper

Influence of the ablation plume on the removal process during ArF-excimer laser photoablation

Christina Doerbecker, Holger Lubatschowski, Stefan Lohmann, Christine Ruff, Omid Kermani, Wolfgang Ertmer

Proceedings Volume 2632, (1996) https://doi.org/10.1117/12.229576

KEYWORDS: Laser ablation, Signal attenuation, Laser beam diagnostics, Natural surfaces, Polymethylmethacrylate, Excimer lasers, Pulsed laser operation, Laser tissue interaction, Absorption, Tissues

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Proceedings Article | 10 January 1996 Paper

Characterization of laser-induced pressure transients by means of piezoelectric PVDF films

Stefan Lohmann, Andreas Olmes, Holger Lubatschowski, Wolfgang Ertmer

Proceedings Volume 2624, (1996) https://doi.org/10.1117/12.229541

KEYWORDS: Capacitance, Resistance, Signal detection, Algorithm development, Spatial resolution, Signal processing, Polymethylmethacrylate, Aluminum, Reflection, Fourier transforms

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Proceedings Article | 1 February 1994 Paper

Thermal and mechanical damage of corneal tissue after free-running and Q-switched mid-infrared laser ablation

Flurin Koenz, Martin Frenz, Hans Pratisto, Heinz Weber, Holger Lubatschowski, Omid Kermani, Wolfgang Ertmer, Hans Altermatt, Thomas Schaffner

Proceedings Volume 2077, (1994) https://doi.org/10.1117/12.168015

KEYWORDS: Laser ablation, Cornea, Laser tissue interaction, Tissues, Pulsed laser operation, Er:YAG lasers, Q switched lasers, Scanning electron microscopy, Mid-IR, Q switching

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Showing 5 of 91 publications

Conference Committee Involvement (10)

Frontiers in Ultrafast Optics: Biomedical, Scientific, and Industrial Applications XI

23 January 2011 | San Francisco, California, United States

Frontiers in Ultrafast Optics: Biomedical, Scientific and Industrial Applications X (Formerly: Commercial and Biomedical Applications of Ultrafast Lasers)

24 January 2010 | San Francisco, California, United States

Advanced Technology and Instrumentation in Otolaryngology: Lasers, Optics, Radio Frequency, and Related Technology

23 January 2010 | San Francisco, California, United States

Commercial and Biomedical Applications of Ultrafast Lasers IX

25 January 2009 | San Jose, California, United States

Advanced Technology and Instrumentation in Otolaryngology: Lasers, Optics, Radio Frequency, and Related Technology

24 January 2009 | San Jose, California, United States

Showing 5 of 10 Conference Committees

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