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18 June 2024 1265 nm laser irradiation activates antioxidant system in B16-F10 and CHO-K1 cells
Anna V. Khokhlova, Dinara R. Dolgova, Aigul K. Gilmutdinova, Igor O. Zolotovskii, Valeria A. Ribenek, Yury V. Saenko, Dmitrii A. Stoliarov, Sergei G. Sokolovski, Edik U. Rafailov, Dmitriy A. Korobko, Igor Meglinski, Alexander Bykov, Andrei A. Fotiadi
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Proceedings Volume 13010, Tissue Optics and Photonics III; 1301010 (2024) https://doi.org/10.1117/12.3022484
Event: SPIE Photonics Europe, 2024, Strasbourg, France
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Abstract
Photodynamic therapy is an effective modality for treating advanced melanoma. However, melanoma's inherent resistance to laser radiation hinders its widespread clinical application. The near-infrared laser radiation range of 1264-1270 nm offers unique properties: firstly, its ability to penetrate melanin-producing cells, and secondly, its capability to generate singlet oxygen without xenobiotics. We assess the impact of continuous wave 1265 nm laser radiation on an antioxidant defense system in melanoma B16-F10 and normal CHO-K1 cells. We observe a time-dependent increase in superoxide dismutase and glutathione-S-transferase activities, fluctuations in reduced glutathione levels, as well as a simultaneous increase in melanoma cell proliferation and cell death. We hypothesize that the differential activation of cellular antioxidant defense mechanisms contributes to melanoma cells' resilience to laser radiation.
(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.
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Anna V. Khokhlova, Dinara R. Dolgova, Aigul K. Gilmutdinova, Igor O. Zolotovskii, Valeria A. Ribenek, Yury V. Saenko, Dmitrii A. Stoliarov, Sergei G. Sokolovski, Edik U. Rafailov, Dmitriy A. Korobko, Igor Meglinski, Alexander Bykov, and Andrei A. Fotiadi "1265 nm laser irradiation activates antioxidant system in B16-F10 and CHO-K1 cells", Proc. SPIE 13010, Tissue Optics and Photonics III, 1301010 (18 June 2024); https://doi.org/10.1117/12.3022484
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KEYWORDS
Laser radiation
Laser irradiation
Melanoma
Cell death
Cancer
Oxygen
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