Analyzing SERS reproducibility and performance: the role of illumination area

Mehdi Feizpour; Qing Liu; Hugo Thienpont; Wendy Meulebroeck; Heidi Ottevaere

doi:10.1117/12.3016316

10 June 2024 Analyzing SERS reproducibility and performance: the role of illumination area

Mehdi Feizpour, Qing Liu, Hugo Thienpont, Wendy Meulebroeck, Heidi Ottevaere

Proceedings Volume 12991, Nanophotonics X; 129910K (2024) https://doi.org/10.1117/12.3016316
Event: SPIE Photonics Europe, 2024, Strasbourg, France

Abstract

Surface-enhanced Raman Spectroscopy (SERS) is a powerful optical sensing technique widely used in fields like medicine, microbiology, and environmental analysis. Planar SERS substrates are preferred for their ease of integration into lab-on-chip systems and superior reproducibility. Substrate performance is assessed using metrics like enhancement factor, sensitivity, and reproducibility. Many experimental and post-processing factors can influence these metrics and their interpretations, with one of the most critical being the illumination area—essentially, the number of hotspots generating the signal. We investigated with Raman mapping the impact of the illumination area on five SERS substrates showing that a larger illumination area improves reproducibility on random structures, while it sacrifices resolution. Furthermore, a larger illumination area leads to more stable signals, particularly in irregular nanostructures, yielding higher sensitivity. In conclusion, choosing a SERS substrate should consider the trade-off between uniformity for resolution and larger illumination area for signal reproducibility.

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(2024) Published by SPIE. Downloading of the abstract is permitted for personal use only.

Citation Download Citation

Mehdi Feizpour, Qing Liu, Hugo Thienpont, Wendy Meulebroeck, and Heidi Ottevaere "Analyzing SERS reproducibility and performance: the role of illumination area", Proc. SPIE 12991, Nanophotonics X, 129910K (10 June 2024); https://doi.org/10.1117/12.3016316

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KEYWORDS

Surface enhanced Raman spectroscopy

Raman spectroscopy

Reproducibility

Scanning electron microscopy

Nanostructures

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