Multi-scale investigation of Alzheimer’s disease brain tissue using 1060 nm swept source optical coherence tomography (Conference Presentation)

Matthias Salas; Johanna Gesperger; Antonia Lichtenegger; Michael Niederleithner; Laurin Ginner; Adelheid Woehrer; Bernhard Baumann; Tilman Schmoll; Wolfgang Drexler; Rainer A. Leitgeb

doi:10.1117/12.2544765

9 March 2020 Multi-scale investigation of Alzheimer’s disease brain tissue using 1060 nm swept source optical coherence tomography (Conference Presentation)

Matthias Salas, Johanna Gesperger, Antonia Lichtenegger, Michael Niederleithner, Laurin Ginner, Adelheid Woehrer, Bernhard Baumann, Tilman Schmoll, Wolfgang Drexler, Rainer A. Leitgeb

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Proceedings Volume 11226, Neural Imaging and Sensing 2020; 112260T (2020) https://doi.org/10.1117/12.2544765
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

We demonstrate imaging of amyloid-beta plaques in ex-vivo Alzheimer’s disease brain tissue using a 1060 nm swept source optical coherence tomography setup. This instrument enabled a global investigation of the brain tissue with a large field of view of 8 mm x 8 mm as well as sequential high resolution imaging. Amyloid-beta (A-β) plaques were identified as highly scattering features. Results were in good agreement with immunohistochemically stained images gained by histology.

Conference Presentation

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Matthias Salas, Johanna Gesperger, Antonia Lichtenegger, Michael Niederleithner, Laurin Ginner, Adelheid Woehrer, Bernhard Baumann, Tilman Schmoll, Wolfgang Drexler, and Rainer A. Leitgeb "Multi-scale investigation of Alzheimer’s disease brain tissue using 1060 nm swept source optical coherence tomography (Conference Presentation)", Proc. SPIE 11226, Neural Imaging and Sensing 2020, 112260T (9 March 2020); https://doi.org/10.1117/12.2544765

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KEYWORDS

Optical coherence tomography

Alzheimer's disease

Brain

Tissue optics

Light scattering

Nondestructive evaluation

Scattering

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