Mr. Grant Daly Profile

Grant Daly

at Whiddon College of Medicine

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Proceedings Article | 10 April 2023 Presentation + Paper

ImageNomer: developing an interactive graphical analysis tool for examining fMRI and omics data

Anton Orlichenko, Grant Daly, Jack Freeman, Yu-Ping Wang

Proceedings Volume 12468, 1246812 (2023) https://doi.org/10.1117/12.2654311

KEYWORDS: Functional magnetic resonance imaging, Feature selection, Data modeling, Principal component analysis, Visualization, Genomics, Open source software, Software, Software development

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It can be difficult to identify trends and perform quality control in large, high-dimensional fMRI or omics datasets. To remedy this, we develop ImageNomer, a data visualization and analysis tool that allows inspection of both subject-level and cohort-level features. The tool allows visualization of phenotype correlation with functional connectivity (FC), partial connectivity (PC), dictionary components (PCA and our own method), and genomic data (single-nucleotide polymorphisms, SNPs). In addition, it allows visualization of weights from arbitrary ML models. ImageNomer is built with a Python backend and a Vue frontend. We validate ImageNomer using the Philadelphia Neurodevelopmental Cohort (PNC) dataset, which contains multitask fMRI and SNP data of healthy adolescents. Using correlation, greedy selection, or model weights, we find that a set of 10 FC features can explain 15% of variation in age, compared to 35% for the full 34,716 feature model. The four most significant FCs are either between bilateral default mode network (DMN) regions or spatially proximal subcortical areas. Additionally, we show that whereas both FC (fMRI) and SNPs (genomic) features can account for 10-15% of intelligence variation, this predictive ability disappears when controlling for race. We find that FC features can be used to predict race with 85% accuracy, compared to 78% accuracy for sex prediction. Using ImageNomer, this work casts doubt on the possibility of finding unbiased intelligence-related features in fMRI and SNPs of healthy adolescents.

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