Mr. Xiang Chen Profile

Xiang Chen

at Xi'an Jiaotong Univ

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Author

Publications (3)

Proceedings Article | 26 March 2008 Paper

Gaussian weighted projection for visualization of cardiac calcification

Xiang Chen, Ke Li, Robert Gilkeson, Baowei Fei

Proceedings Volume 6918, 691831 (2008) https://doi.org/10.1117/12.772597

KEYWORDS: Tissues, Visualization, Heart, Image segmentation, Image visualization, Arteries, Calcium, Radiography, Computed tomography, Bone

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Proceedings Article | 10 May 2007 Paper

In vivo small animal imaging for early assessment of therapeutic efficacy of photodynamic therapy for prostate cancer

Baowei Fei, Hesheng Wang, Xiang Chen, Joseph Meyers, John Mulvilhill, Denise Feyes, Nancy Edgehouse, Jeffrey Duerk, Thomas Pretlow, Nancy Oleinick

Proceedings Volume 6511, 651102 (2007) https://doi.org/10.1117/12.708718

KEYWORDS: Photodynamic therapy, Tumors, Magnetic resonance imaging, Prostate cancer, In vivo imaging, Preclinical imaging, Cancer, Image segmentation, Image analysis, Medical imaging

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We are developing in vivo small animal imaging techniques that can measure early effects of photodynamic therapy (PDT) for prostate cancer. PDT is an emerging therapeutic modality that continues to show promise in the treatment of cancer. At our institution, a new second-generation photosensitizing drug, the silicon phthalocyanine Pc 4, has been developed and evaluated at the Case Comprehensive Cancer Center. In this study, we are developing magnetic resonance imaging (MRI) techniques that provide therapy monitoring and early assessment of tumor response to PDT. We generated human prostate cancer xenografts in athymic nude mice. For the imaging experiments, we used a highfield 9.4-T small animal MR scanner (Bruker Biospec). High-resolution MR images were acquired from the treated and control tumors pre- and post-PDT and 24 hr after PDT. We utilized multi-slice multi-echo (MSME) MR sequences. During imaging acquisitions, the animals were anesthetized with a continuous supply of 2% isoflurane in oxygen and were continuously monitored for respiration and temperature. After imaging experiments, we manually segmented the tumors on each image slice for quantitative image analyses. We computed three-dimensional T2 maps for the tumor regions from the MSME images. We plotted the histograms of the T2 maps for each tumor pre- and post-PDT and 24 hr after PDT. After the imaging and PDT experiments, we dissected the tumor tissues and used the histologic slides to validate the MR images. In this study, six mice with human prostate cancer tumors were imaged and treated at the Case Center for Imaging Research. The T2 values of treated tumors increased by 24 ± 14% 24 hr after the therapy. The control tumors did not demonstrate significant changes of the T2 values. Inflammation and necrosis were observed within the treated tumors 24 hour after the treatment. Preliminary results show that Pc 4-PDT is effective for the treatment of human prostate cancer in mice. The small animal MR imaging provides a useful tool to evaluate early tumor response to photodynamic therapy in mice.

Proceedings Article | 26 March 2007 Paper

Automatic intensity-based 3D-to-2D registration of CT volume and dual-energy digital radiography for the detection of cardiac calcification

Xiang Chen, Robert Gilkeson, Baowei Fei

Proceedings Volume 6512, 65120A (2007) https://doi.org/10.1117/12.710192

KEYWORDS: Image registration, Radiography, X-ray computed tomography, Arteries, Computed tomography, Image fusion, 3D image processing, X-rays, X-ray imaging, Computer aided diagnosis and therapy

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