The structural elucidation of complex systems may be simplified with multi-dimensional spectroscopic techniques with some combination of spatial and spectral resolution. Raman spectroscopy permits the addition of another variable to this scenario -- excitation wavelength. Data obtained using excitation wavelengths from the UV (244 nm) to near-IR (785 nm) regions will be presented showing the qualitative and quantitative study of diamond-like carbon (DLC), silicon, and other systems of an industrial or biomedical nature. The choice of appropriate wavelength provides an additional advantage over other spectroscopic techniques for elucidating specific structural information from these systems. The advantages of UV-Raman for materials science and thin film studies will be considered. The design of instruments and probes for the application of Raman spectroscopy to industrial process control and the development of Raman spectroscopic libraries for contaminant analysis will be discussed.
Imaging methodologies present some of the most exciting new frontiers in the biological and medical sciences. Raman spectroscopic imaging combines the power of chemical imaging with the spatial resolution for translating microscopic spectroscopic information into statements relevant to biological and medical function. Imaging results will be presented using mapping, dielectric filters, and liquid- crystalline tunable filters at different excitation wavelengths for selectively determining the spatial distribution of biomaterials in a variety of biological systems.
Recent improvements in filters, multi-element detectors and instrument design have transformed Raman spectroscopy from a difficult to use specialist technique into a widely used multi-dimensional spectroscopic method. Raman spectroscopy is non destructive and offers a spatial resolution of one micro or better. A Raman spectrum gives specific information regarding the chemical bonding of molecules and can therefore be used to identify different molecules in a system. Through the use of xyz mapping techniques, specific types of material can be imaged in living cells, drug formulations and polymer mixtures to give but a few examples. Raman technologies allow areas as large as 500 microns to be imaged directly using filters tuned specifically to look for a particular chemical species. The Raman technique uses visible or close to visible light which is ideal for coupling into optical fibers. It is therefore very easy to build ruggedized spectrometers using fiber optic probes for remote sensing in extremely difficult and/or hazardous environments; for example process monitoring and recently endoscopic diagnostic work in living subjects. This paper will describe the methodology used in direct Raman imaging, Raman mapping experiments and remote sensing with reference to specific examples of biological, pharmaceutical, mineral and crystal studies.
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