Dr. Sheng Fu Profile

Dr. Sheng Fu

Student at Nanyang Technological Univ

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Publications (4)

Proceedings Article | 14 April 2006 Paper

Detection of colorectal cancer using time-resolved autofluorescence spectrometer

Sheng Fu, Leong-Chuan Kwek, Teck-Chee Chia, Chu-Sing Lim, Choong-Leong Tang, Wuan-Suan Ang, Miao-Chang Zhou, Po-Ling Loke

Proceedings Volume 6191, 61910M (2006) https://doi.org/10.1117/12.663257

KEYWORDS: Tissues, Colorectal cancer, Spectroscopy, Luminescence, Tissue optics, Fluorescence spectroscopy, Picosecond phenomena, Cancer, Time resolved spectroscopy, Quantum mechanics

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Proceedings Article | 13 October 2005 Paper

Application of laser-induced autofluorescence spectra detection system in human colorectal cancer in-vivo screening

Teck Chee Chia, Sheng Fu, Yee Hong Chia, Leong Chuan Kwek, Choong Leong Tang

Proceedings Volume 5969, 59691I (2005) https://doi.org/10.1117/12.632130

KEYWORDS: Atrial fibrillation, Tissues, Endoscopy, Biopsy, Natural surfaces, Rectum, Optical fibers, In vivo imaging, Colorectal cancer, Diagnostics

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This study aimed at applying Laser induced-autofluorescence (LIAF) diagnostics method as an in-vivo screening of colorectal polyplcancer. The spectrum algorithm based on the ratio of autofluorescence intensity was used to identify the diseased tissues from the normal tissues as it was generally performed better than an algorithm based only simply on the intensity of the spectrum. Histopathological biopsy results were compared with the detected AF spectra characteristics for different kinds of polyps. 73 patients had been examined via the LIAF spectroscopy detection system during their colonoscopy screening in Endoscopy Center, Singapore General Hospital. The autofluorescence from the surface of the colorectal tissues under 405 nm laser light excitation was detected using our detecting system. In the experimental investigation two groups of patients were involved. One group was "abnormal" group. There were 25 patients belonging to this group since polyps or carcinoma was found in their colorectal tract during colonoscopy. The histopathology reports confirm the group classification. Total 36 polyps' AF spectra and 9 carcinoma' AF spectra were detected from 25 patients of the abnormal group during their regular endoscopy examination. The intensity ratios R_I-680/I-500 and R_I-630/I-500 of polyps/cancerous AF spectra and intensity ratios of corresponding normal colorectal AF spectra were calculated. Two critical intensity ratios for separating the AF intensity ratios R_I-680/I-500 and R_I-630/I-500 of normal and abnormal colorectal tissues were defined as 0.5 and 0.6 respectively. Using the critical intensity ratio values, 48 "normal" group patients' rectums were checked via the LIAF detection system. There were 20 patients (41.7%) whose AF spectra of colorectal tract mucosa belonging to abnormal spectra. However, these 20 patients had not been found under white light via traditional endoscopy. For small diseased area like small plat polyp disease and carcinoma, it was very difficult to identify under white light by endoscopy. However, the LIAF spectra technique and AF intensity ratio algorithm was able to detect these kinds of abnormal area earlier than traditional endoscopy. Using this algorithm, it is able to identify the onset of abnormal tissue growth during real-time clinical endoscope examination.

Proceedings Article | 9 October 2003 Paper

Comparison of human colorectal normal tissue with cancerous tissue autofluorescence image by optical sectioning with a confocal laser-scanning microscope

Sheng Fu, Teck-Chee Chia, Leong Chuan Kwek, Cheong Hoong Diong, Choong Leong Tang, Francis Choen, Shankar Krishnan

Proceedings Volume 5139, (2003) https://doi.org/10.1117/12.500203

KEYWORDS: Tissue optics, Tissues, Confocal microscopy, Laser tissue interaction, Laser scanners, Microscopes, Biopsy, Spectroscopy, Imaging systems, Surgery

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Proceedings Article | 8 October 2003 Paper

Application of laser-induced autofluorescence spectra detection in human colorectal cancer screening

Sheng Fu, Teck-Chee Chia, Leong Chuan Kwek, Cheong Hoong Diong, Choong Leong Tang, Francis Choen, S. Krishnan

Proceedings Volume 5141, (2003) https://doi.org/10.1117/12.500455

KEYWORDS: Colon, Atrial fibrillation, Tissues, Endoscopy, Biopsy, Rectum, Colorectal cancer, Diagnostics, Tissue optics, Luminescence

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