Prof. Nima Tabatabaei Profile

Prof. Nima Tabatabaei

Associate Professor at York Univ

SPIE Involvement:

Author

Publications (22)

Proceedings Article | 13 March 2024 Presentation

Low-cost end-user photo-thermal device for sensitive detection and quantification of analytes in fluidic samples

Derek Hayden, Baseer Yousufzai, Raha Golsorkhi, Nakisa Samadi, Nima Tabatabaei

Proceedings Volume PC12850, PC1285004 (2024) https://doi.org/10.1117/12.3001793

KEYWORDS: Statistical analysis, Gold nanoparticles, Modeling, Data modeling, COVID 19, Surface plasmons, Diseases and disorders, Design and modelling, Demodulation, Control systems

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Proceedings Article | 13 March 2024 Presentation

Affordable optofluidic add-on for continuous light sheet imaging of larval and adult c. elegans

Faraz Rahimpouresfahani, Pouya Rezai, Nima Tabatabaei

Proceedings Volume PC12837, PC128370C (2024) https://doi.org/10.1117/12.3001808

KEYWORDS: Optofluidics, Microscopes, Neurodegeneration, Miniaturization, Microfluidics, Interfaces, Integrated optics, Image resolution, Free space, Fluorescence microscopy

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Proceedings Article | 13 March 2024 Paper

Whole-eye OCT imaging of refractive errors in genetically modified zebrafish

Shiva Sabour, Cherie A. Brown-Panton, Anna Kotova, Georg S. Zoidl, Christiane Zoidl, Georg Zoidl, Nima Tabatabaei

Proceedings Volume 12830, 128300D (2024) https://doi.org/10.1117/12.3001760

KEYWORDS: Optical coherence tomography, Eye, Imaging systems, Error analysis, Visualization, Genetics, Tissues, Control systems, Switches, Eye models

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Proceedings Article | 12 May 2022 Presentation

Handheld Point-of-Care Device for the Quantification of Anti-SARS-CoV-2 Antibodies

Damber Thapa, Nakisa Samadi, Nima Tabatabaei

Proceedings Volume PC11968, PC1196803 (2022) https://doi.org/10.1117/12.2607778

KEYWORDS: Point-of-care devices, Standards development, Thermography, Thermal sensing, Therapeutic antibodies, Plasma, Nanoparticles, Infrared sensors, Infrared radiation, Infrared imaging

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Proceedings Article | 7 March 2022 Presentation + Paper

Detection of lipid at video rate with spectroscopic transient-mode photo-thermal optical coherence tomography (TM-PT-OCT)

Mohammad Hossein Salimi, Martin Villiger, Nima Tabatabaei

Proceedings Volume 11948, 119480C (2022) https://doi.org/10.1117/12.2607635

KEYWORDS: Photothermal effect, Optical coherence tomography, Spectroscopy, Collagen, Video, Absorption, Signal to noise ratio, Imaging systems, Laser spectroscopy, Tissues, Optical spectroscopy

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Proceedings Article | 4 March 2022 Presentation + Paper

Optofluidic device for light-sheet fluorescence microscopy of C. elegans with a conventional wide-field microscope

Mehran Behrouzi, Faraz Rahimpouresfahani, Khaled Youssef, Pouya Rezai, Nima Tabatabaei

Proceedings Volume 11964, 1196402 (2022) https://doi.org/10.1117/12.2607134

KEYWORDS: Microscopes, Optofluidics, Imaging systems, Luminescence, Microscopy, Microfluidics, Confocal microscopy, Confocal fluorescent microscopy, Fluorescent proteins

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SPIE Journal Paper | 10 December 2021 Open Access

Low-cost optofluidic add-on enables rapid selective plane illumination microscopy of C. elegans with a conventional wide-field microscope

Mehran Behrouzi, Khaled Youssef, Pouya Rezai, Nima Tabatabaei

JBO, Vol. 26, Issue 12, 126501, (December 2021) https://doi.org/10.1117/12.10.1117/1.JBO.26.12.126501

KEYWORDS: Optofluidics, Microscopes, Imaging systems, Neurons, Microscopy, Visualization, Microfluidics, Objectives, Nerve, Image resolution

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Significance: Selective plane illumination microscopy (SPIM) is an emerging fluorescent imaging technique suitable for noninvasive volumetric imaging of C. elegans. These promising microscopy systems, however, are scarce in academic and research institutions due to their high cost and technical complexities. Simple and low-cost solutions that enable conversion of commonplace wide-field microscopes to rapid SPIM platforms promote widespread adoption of SPIM by biologist for studying neuronal expressions of C. elegans. Aim: We sought to develop a simple and low-cost optofluidic add-on device that enables rapid and immobilization-free volumetric SPIM imaging of C. elegans with conventional fluorescent microscopes. Approach: A polydimethylsiloxane (PDMS)-based device with integrated optical and fluidic elements was developed as a low-cost and miniaturized SPIM add-on for the conventional wide-field microscope. The developed optofluidic chip contained an integrated PDMS cylindrical lens for on-chip generation of the light-sheet across a microchannel. Cross-sectional SPIM images of C. elegans were continuously acquired by the native objective of microscope as worms flowed in an L-shape microchannel and through the light sheet. Results: On-chip SPIM imaging of C. elegans strains demonstrated possibility of visualizing the entire neuronal system in few seconds at single-neuron resolution, with high contrast and without worm immobilization. Volumetric visualization of neuronal system from the acquired cross-sectional two-dimensional images is also demonstrated, enabling the standard microscope to acquire three-dimensional fluorescent images of C. elegans. The full-width at half-maximum width of the point spread function was measured as 1.1 and 2.4 μm in the lateral and axial directions, respectively. Conclusion: The developed low-cost optofluidic device is capable of continuous SPIM imaging of C. elegans model organism with a conventional fluorescent microscope, at high speed, and with single neuron resolution.

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Proceedings Article | 9 December 2021 Paper

Development of an opto-thermo-mechanical theoretical model for photothermal optical coherence tomography imaging of multilayered samples

Mohammad Hossein Salimi, Martin Villiger, Nima Tabatabaei

Proceedings Volume 11924, 119240B (2021) https://doi.org/10.1117/12.2616018

KEYWORDS: Optical coherence tomography, 3D modeling, Modulation, Coherence imaging, Statistical modeling, Absorption, Tissues, Optical imaging, Multilayers, Light scattering

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Proceedings Article | 5 March 2021 Presentation

Portable thermo-photonic device for highly sensitive detection and quantification of target analytes in lateral flow immunoassay

Damber Thapa, Nakisa Samadi, Nima Tabatabaei

Proceedings Volume 11651, 1165107 (2021) https://doi.org/10.1117/12.2580660

KEYWORDS: Target detection, Signal detection, Laser applications, Thermography, Point-of-care devices, Plasma, Particles, Nanoparticles, Infrared radiation, Gold

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Proceedings Article | 5 March 2021 Presentation + Paper

New model for understanding the relationship between tissue composition and photothermal optical coherence tomography signals

Mohammadhossein Salimi, Martin Villiger, Nima Tabatabaei

Proceedings Volume 11655, 116550Q (2021) https://doi.org/10.1117/12.2583046

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SPIE Journal Paper | 23 December 2020 Open Access

Effects of lipid composition on photothermal optical coherence tomography signals

Mohammad Hossein Salimi, Martin Villiger, Nima Tabatabaei

JBO, Vol. 25, Issue 12, 120501, (December 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.12.120501

KEYWORDS: Optical coherence tomography, Tissues, Absorption, Modulation, Water, Tissue optics, Nonlinear optics, Molecules, Phase measurement, Coherence (optics)

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Proceedings Article | 23 April 2020 Paper

Comparison of low cost and research grade active thermography platforms for detection of early dental caries

D. Thapa, N. Samadi, A. Parkhimchyk, N. Tabatabaei

Proceedings Volume 11354, 1135409 (2020) https://doi.org/10.1117/12.2555279

KEYWORDS: Dental caries, Cameras, Imaging systems, Teeth, Thermography, Infrared cameras, Image enhancement, Modulation, Phase shift keying, Optical coherence tomography

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Lock-in thermography (LIT) is a non-destructive testing technique with a broad spectrum of applications, spanning from detection of manufacturing defects in industrial samples to early diagnosis of diseases in hard and soft tissues. Nevertheless, commercialization and wide-spread adaption of LIT has long been impeded by the cost (usually $10k-$100k) and size of infrared cameras. In this paper, we demonstrate that this cost and size limitation can be overcome using cell-phone attachment infrared cameras/sensors. Developed low-cost and portable LIT systems use an intensity-modulated near infrared light for illumination while detecting thermal signatures by the low-cost cellphone attachment infrared camera (Seek thermal compact; Android). While the nominal frame rate of camera is less than 9fps, we have deciphered the communication protocol and frame information structure of the camera and set up packets of information and send them to the camera’s default endpoint address and, subsequently, acquire frame data from camera through a corresponding pipe. As such, the developed platform can control camera attributes through a simple USB interface while achieving a stable high frame rate of 33fps. To demonstrate performance of developed low-cost and portable system, two types of LIT experiments were conducted: (i) in response to the recent legalizations of marijuana in Canada, we interrogated photothermal responses of commercially available oral fluid latral flow immunoassays (LFAs), demonstrating reliable detection of THC (the psychoactive substance of cannabis) at concentrations as low as 2 ng/ml. (ii) To demonstrate ability of the system in early detection of dental caries, artificially induced early caries were created on healthy enamel surfaces and imaged with the low cost and portable system at different stages of formation. Results, suggest ability of the system in detection of caries at very early stages when neither x-ray nor visual-tactile inspection can detect them. Both sets of experiments clearly demonstrate the promise of the developed low-cost and portable LIT system in producing reliable LIT images, paving the way for translation of this technology to industry.

Proceedings Article | 13 April 2020 Presentation + Paper

Enhancement of sensitivity and detection limit of lateral flow immunoassays using lock-in thermography

D. Thapa, N. Samadi, N. Patel, N. Tabatabaei

Proceedings Volume 11361, 113610M (2020) https://doi.org/10.1117/12.2555274

KEYWORDS: Imaging systems, Thermography, Cameras, Modulation, Statistical analysis, Medicine, Image processing, Point-of-care devices, Infrared thermal wave imaging, Radiometry, Infrared imaging

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Proceedings Article | 19 April 2017 Presentation

Tethered SECM endoscopic capsule for the diagnosis of eosinophilic esophagitis (Conference Presentation)

Dukho Do, DongKyun Kang, Nima Tabatabaei, Catriona Grant, Norman Nishioka, Mireille Rosenberg, Paul Hesterberg, Qian Yuan, John Garber, Aubrey Katz, Wayne Shreffler, Guillermo Tearney

Proceedings Volume 10040, 100400G (2017) https://doi.org/10.1117/12.2253401

KEYWORDS: Endoscopy, Confocal microscopy, Esophagus, Biopsy, Visualization, Speckle, Gold, Image quality standards, Image resolution, Prototyping

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Eosinophilic Esophagitis (EoE) is an inflammatory disease caused by inhaled or ingested food allergies, and characterized by the infiltration of eosinophils in the esophagus. The gold standard for diagnosing EoE is to conduct endoscopy and obtain multiple biopsy specimens from different portions of the esophagus; an exam is considered positive if more than 15 eosinophils per high power field (HPF) in any of the biopsies. This method of diagnosis is problematic because endoscopic biopsy is expensive and poorly tolerated and the esophageal eosinophil burden needs to be monitored frequently during the course of the disease. Spectrally encoded confocal microscopy (SECM) is a high-speed confocal microscopy technology that can visualize individual eosinophils in large microscopic images of the human esophagus, equivalent to more than 30,000 HPF. Previously, we have demonstrated that tethered capsule SECM can be conducted in unsedated subjects with diagnosed EoE. However, speckle noise and the relatively low resolution in images obtained with the first capsule prototypes made it challenging to distinguish eosinophils from other cells. In this work, we present a next-generation tethered SECM capsule, which has been modified to significantly improve image quality. First, we substituted the single mode fiber with a dual-clad fiber to reduce speckle noise. A gradient-index multimode fiber was fusion spliced at the tip of the dual-clad fiber to increase the effective numerical aperture of the fiber from 0.09 to 0.15, expanding the beam more rapidly to increase the illumination aperture at the objective. These modifications enabled the new SECM capsule to achieve a lateral resolution of 1.8 µm and an axial resolution of 16.1 µm, which substantially improves the capacity of this probe to visualize cellular features in human tissue. The total size of the SECM capsule remained 6.75 mm in diameter and 31 mm in length. We are now in the process of testing this new SECM capsule in humans. Early results using this new SECM capsule suggest that this technology has the potential to be an effective tool for the diagnosis of EoE.

Proceedings Article | 21 February 2017 Paper

Optimal selection of laser modulation parameters in photothermal optical coherence tomography

Ashish Gupta, Martin Villiger, Nima Tabatabaei

Proceedings Volume 10067, 1006718 (2017) https://doi.org/10.1117/12.2252779

KEYWORDS: Modulation, Optical coherence tomography, Diffusion, Laser scattering, Image resolution, Absorption, Refractive index, Chromophores, Thermal modeling, Photothermal effect, Photothermal interactions, Molecular imaging, Systems modeling, Spatial resolution, Statistical modeling

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SPIE Journal Paper | 8 September 2016 Open Access

First step toward translation of thermophotonic lock-in imaging to dentistry as an early caries detection technology

Ashkan Ojaghi, Artur Parkhimchyk, Nima Tabatabaei

JBO, Vol. 21, Issue 09, 096003, (September 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.9.096003

KEYWORDS: Dental caries, Long wavelength infrared, Thermography, Diagnostics, Cameras, Mid-IR, Dentistry, Imaging systems, Infrared imaging, Modulation

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Proceedings Article | 3 May 2016 Presentation

Clinical experience using the tethered capsule-based spectrally encoded confocal microendoscopy for diagnosis of eosinophilic esophagitis (Conference Presentation)

Dukho Do, Sanaz Alali, DongKyun Kang, Nima Tabatabaie, Weina Lu, Catriona Grant, Amna Soomro, Norman Nishioka, Mireille Rosenberg, Paul Hesterberg, Qian Yuan, John Garber, Aubrey Katz, Wayne Shreffler, Guillermo Tearney

Proceedings Volume 9691, 96910L (2016) https://doi.org/10.1117/12.2218559

KEYWORDS: Confocal microscopy, Photomedicine, Esophagus, Biopsy, Endoscopy, Scattering, Gold, Standards development, Reflectivity, Lutetium

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Proceedings Article | 29 February 2016 Paper

A pilot study on the detection of early proximal and occlusal dental caries using long-wave infrared thermophotonic imaging

Ashkan Ojaghi, Artur Parkhimchyk, Nima Tabatabaei

Proceedings Volume 9692, 969209 (2016) https://doi.org/10.1117/12.2212987

KEYWORDS: Long wavelength infrared, Thermography, Infrared detectors, Infrared radiation, Teeth, Diagnostics, Optical inspection, Sensors, Thermal effects, Dental caries, Cameras, Modulation

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SPIE Journal Paper | 23 February 2012 Open Access

On the sensitivity of thermophotonic lock-in imaging and polarized Raman spectroscopy to early dental caries diagnosis

Nima Tabatabaei, Andreas Mandelis, Mehdi Dehghany, Kirk Michaelian, Bennett Amaechi

JBO, Vol. 17, Issue 02, 025002, (February 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.2.025002

KEYWORDS: Raman spectroscopy, Dental caries, Imaging spectroscopy, Teeth, Light scattering, Polarization, Diagnostics, Thermography, Surface finishing, Dentistry

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