This research focuses on exploring the development of graphene oxide quantum dots (GOQDs) for their surface plasmon resonance (SPR) properties and the detection mechanisms involving microRNAs (miRNAs). We have engineered a novel class of GOQDs composites designed to amplify the plasmons' resonance energy states, thereby boosting the interface electric field and enhancing sensing sensitivity. GOQDs exhibit superior fluorescent characteristics and are capable of effectively modulating the resonance and propagation energies of plasmons. They are poised to become a novel kind of material for plasmonic energy modulation. This exploration into miRNAs, particularly miRNA-210, underscores the potential for improved diagnostic and therapeutic strategies, promising advancements in personalized medicine and patient care by facilitating early disease detection and offering insights into novel treatment avenues. Thus, we aimed to assess the potential of circulating miRNAs as sensitive and specific biomarkers for the early diagnosis of preeclampsia. The experimental findings reveal that the linear regression equation for the SPR chip incorporating GOQDs is y = 1.94 + 1.83x, with an R2 value of 0.95, indicating both high sensitivity and high linearity. The GOQDs based SPR a prominent assay designed to detect and quantify mature miRNAs in a fast, specific, accurate and reliable manner. Thus, a SPR biosensor based on GOQDs demonstrates high sensitivity and specificity for detecting miRNA-210, with potential for disease diagnosis applications. Future research will involve testing clinical samples to explore commercial applications for early disease and cancer detection.
Early disease detection represents a cornerstone in the diagnostic and detection approaches of contemporary medicine. Biomedical chips offer swift, precise, and cost-effective solutions tailored to specific medical objectives. This research suggests employing graphene quantum dots (GQDs) in conjunction with surface plasmon resonance (SPR) technology to create biochips designed for the rapid identification of pancreatic cancer. In biological research, graphene quantum dots leverage surface plasmon resonance technology to monitor biomolecular interactions. These experiments focus on the immune response to the pancreatic cancer marker Carbohydrate antigen19-9 (CA19-9) protein, leading to the development of biosensors with high sensitivity and accuracy for swift screening processes. This approach enables the detection of minimal changes around 10 Units/mL, achieving a linear regression coefficient of R2 = 0.90. Consequently, this detection method allows for the rapid diagnosis of pancreatic cancer and the creation of a specific, fast-screening cancer biosensing chip.
This study presents an ultra-sensitive carboxyl-functionalized graphene oxide (GO-COOH)-based surface plasmon resonance (SPR) immunosensor using Carbohydrate antigen (CA) 199 (CA199) biomarker to detect pancreatic cancer. A study of the effect of carboxyl-GO-based biocompatible composites with protein on sensing adhesion and diagnostic engineering is an useful technique. The optical and sensing properties of carboxyl-GO sheets improved sensitivity and affinity for molecular detection of biomarker. In the experiment, the SPR biosensor with carboxyl modified graphene oxide as substrate was tested to detect the immune response of CA 199. The literature indicates that 79% of pancreatic cancer patients have carbohydrate antigen 19-9 content above 37 unit/ml. The experimental results show that the lowest antigen detection limit of surface plasmon resonance biochip with carboxyl modified graphene oxide as the substrate can reach 10 unit/ml.
The traditional surface plasmon resonance (SPR) instrument has the advantages of real time, label-free and high sensitivity. This study mainly makes the traditional SPR instruments miniaturized into active plasmon colorimetric biosensors, which is used for point of care and further improve the medical Level. Nano-printed technology is a simple process technology that used in the preparation of nano-structure with advantages of low cost and high production, for the future active plasmon colorimetric biosensors manufacturing has a very high Production advantages. Organic light emitting diodes have the uniformity of light intensity at different angles, which is one of the indispensable conditions in the detection process of plasmon bioassay. In this experiment, it is proved that the grating period is 555 nm, when the refraction value change from 1 to 1.33 the coupling wavelength shifted about 190 nm, the minimum refractive index is 1.736×10-3 RIU. The binding reaction with β-hCG (1 μM) was enhanced by the bonding of Peptide (1 mM) with gold nanoparticles (15 nm), which was about 43.88 times higher than that of the original peptide (1 mM) and β-hCG (1 μM). That the minimum refraction value of the change in the sensitivity increased to 3.956×10-5 RIU. After the peptides (33 nm) bonded Peptide (1 mM) and β-hCG (1 μM) were used for the active plasmon colorimetric biosensors. The plasmon at a measuring angle of 5° wavelength of the emission shifted 16 nm, and the measurement angle is 4 nm at the measuring angle of -5°.
In this paper, we're binding gold nanoparticles (GNPs) and reduced graphene oxide (rGO) by cystamine (Cys). The PEDOT:PSS mix GNPs/Cys/rGO as a hole transport layer of the solar cell. From the experimental result shows the PEDOT:PSS/GNPs/Cys/rGO/ITO film than ITO film have the best transmittance. It's transmittance was decreased for 1.01% at 545 nm wavelength. The sheet resistance of PEDOT:PSS/GNPs/Cys/rGO/ITO was reduce than PEDOT:PSS/ITO, when it was doped with Gold nanoparticles (GNPs) and rGO on ITO glass. The former is than the latter decreased for 1%. For these reasons due to impact by surface doping of composite plasmonic material.
We have investigated the effect of concentric circles geometry on the performance of focusing plasmonic circular grating (PCG)-coupled surface-omnidirectional absorption. We wish to highlight the essential characteristics of plasmonic circular grating nanostructure to assist researchers in developing and advancing suitable organic solar cells (OSC) for unique applications. Exactly how plasmonic enhancement and the absorption characteristics of the organic materials (P3HT:PCBM and PEDOT:PSS) interact with each other is also examined. We present experimental studies of broadband absorption enhancement in PCG structure. We show that the PCG structure can result in broadband absorption enhancement, the overall optical absorption in organic film can be greatly enhanced up to ~111.2 % compared to the planar device without grating.
We describe a fundamental study on the plasmonic properties and advanced biosensing mechanisms of functionalized graphene. We discuss a specific design using modified carboxyl groups, which can modulate surface plasmon (SP) coupling and provide an advantage for their binding to the sensing layer with high-performance affinity in an immunological reaction. The functionalized graphene-based surface plasmon resonance (SPR) biosensors have three advantages: high performance, high sensitivity, and excellent molecular kinetic response. In the future, functionalized graphene sheets will make a unique contribution to photonic and SPR diagnosis devices. We wish to highlight the essential characteristics of functionalized graphene-based SPR biosensors to assist researchers in developing and advancing suitable biosensors for unique applications.
This paper is intended to demonstrate a facile and effective method to construct single layer graphene films onto the
self-assembled monolayer (SAM) at Au electrodes based surface plasmon resonance (SPR) biochips integrated
loop-mediated isothermal amplification (LAMP) for tuberculosis bacillus (TB) detection. It is a novel
Au-SAM-graphene nanocomposites and taking advantages of the striking properties of both graphene and Au film,
fundamental understanding in hybrid material manipulation and new electrochemical properties can be obtained. The
sensitivity of TB detection in the LAMP-based assay for the amplification of the Insertion Sequence 6110 (IS6110)
samples was determined by a single-layer graphene/Au thin film and compared with that of a conventional Au/Cr-based
SPR chips. The results show that a graphene/Au SPR offers a potentially powerful assay, with a highly sensitive analysis,
that may be applicable as an important tool for bio-marker detection.
This paper is intended to demonstrate the effect of surface plasmon coupled emission (SPGCE) on the plasmonic
response of lamellar grating in both Au-grating/Alq3 and PR-grating/Alq3 nanostructures. Recently, intriguing studies on
an appropriate nanostructure of the corrugation allows the non-radiative SPP mode to be coupled out as light into the far
field with direction determined by the grating diffraction condition. It has also been shown that surface plasmon coupled
emissions (SPCE) from fluorescent molecules by incident wave excite an evanescent field near the periodic metallic
structure, Kretschmann configuration and multilayer grating structure to increase the radiation efficiency. In this paper,
we propose to use this technique of SPGCE has performed on the localized surface plasmon (LSP) and surface plasmon
band gap (SPBG) characteristics of the lamellar grating nanostructure.
We demonstrate the surface plasmon grating coupled emission (SPGCE) from excited organic layer on metal grating in
organic/metal structure. The emissions correspond to the resonant condition of SPPs modes on the Alq3/Au interface and
grating couple to the Au/air interface for the emission of light. In our experiments, we used different pitch sizes to
control plasmonics band-gap which produced highly directional SPGCE with enhanced intensity. In our experiments,
four different pitches, including 400 nm, 500 nm, 600 nm and 800 nm, were adopted for the one-dimensional lamellar
grating devices. They were grating devices with 1-D pattern an exposure area of 1.2×1.2 mm2 fabricated by
Electron-Beam Lithography system. The experimeantal and theoretical results showed that SPGCE at different pitch can
match a linear shifting of momentum (ΔK) of about 4.8 μm-1 per 100 nm pitch size with 4 times enhanced intensity. We
have to modify our experimental design of decreasing Au thin film thickness, it became more pronounced in the 20 nm
Au film at the pitch of 600 nm structure. In this study, the emission filtering is enabled by evanescent wave coupling
across the upper layer metal film. In this way, we can probe the response of the SPGCE system when the two modes are
brought into resonance. In our experiments, we used different pitch sizes to control plasmonic band-gap which produced
highly directional SPGCE with enhanced intensity. Based on our calculation, SPGCE showed a color change from
yellowish green to orange at a certain viewing angle, while the concentration of contacting glucose was increased from
10 to 40%, corresponding to the refractive index change from 1.3484 to 1.3968. This indicated a potential application of
low-cost, integrated, and disposable refractive-index sensor. It is proposed for the development of novel bio-devices,
which is expected to improve the capability of electroluminescent bio-plasmonic devices in the future.
In this study, we proposed a new approach to make a low-cost, high-pressure and easy-to-made fiber optic pressure
sensor for human disc pressure measurement. The principle of this sensor is based on Fresnel reflection equations. The
sensor is sealed in a 25G needle (500 micron outer diameter), and coated with a thin film on the tip of the sensor. The
developed system is capable of measuring pressure up to 10 bar.
We report the influence of organic electroluminescence (OEL) device on the color tunability and emission efficiency
enhancement by surface plasmon grating coupled emission (SPGCE). The effect of coupling active surface plasmon
polaritons (SPPs) on the metal nanostructure grating with organic material interface was studied. The dispersion relation
was obtained from angle-resolved emission measurements. The combination of organic/metal interface SPPs mode
allows specific directional emission rather than isotropic emission. Control of light emission angle in the SPGCE is
dependent upon the index of refraction at the organic/metal/dielectric interface. Recent experimental results and potential
applications of an active plasmonics biosensor with enhanced resonant energy emission due to interactions on the
organic/metal nano-grating were presented and discussed.
This study proposed a novel approach to replace the traditional surface plasmon resonance (SPR) bulk prism by
microlens arrays (MLAs). It demonstrated the effect that coupling SPR on the optical response of microlens arrays
structure. Surface plasmons are features specific to the interface of metal-dielectric. They are due to charge density
oscillations in the metal, accompanied by electromagnetic field dissipation in the metal and in the dielectric. SPR
biosensor bulk prism technology has been commercialized and SPR biosensors have become a central tool for
characterizing and quantifying biomolecular interactions. We will used this microlens arrays coupling SPP phenomenon,
which gives rise to selective spectral response due to a local field enhancement interrelating the optical and biochemical
domains.
This paper is intended to demonstrate the effect of coupled long-range surface plasmon polaritons (LRSPPs) on the optical response of a lamellar grating nanostructure with organic material on the surface. This phenomenon gives rise to a selective spectral response and a local field enhancement which can be used in the context of nano-optics. This novel structure of nanofabricated device, consisting of coupled organic/metal nanostructure with specific width and symmetric dielectric structure. By designing the size and shape of the grating nanostructure, and the location of the organic Alq3 relative to the surfaces, Alq3 can be quenched, display increases in emission quantum yield, and decreasing the lifetimes. The combinations of organic/metal interface LRSPP mode can emit specific direction rather than isotropic emission. We discuss recent experimental results and potential applications in biosensor, organic light emitting diodes (OLEDs), polymer laser and organic solar cells of organic/metal grating enhanced emission resonance energy interactions.
KEYWORDS: Sensors, Amplifiers, Signal detection, Signal processing, Telecommunications, Information technology, Self-assembled monolayers, Receivers, Nanotechnology, Interfaces
Attempts to develop a Wireless Health Advanced Mobile Bio-diagnostic System (abbreviated as WHAM-BioS) have arisen from the need to monitor the health status of patients under long-term care programs. The proposed WHAM-BioS as presented here was developed by integrating various technologies: nano/MEMS technology, biotechnology, network/communication technology, and information technology. The biochips proposed not only detect certain diseases but will also report any abnormal status readings on the patient to the medical personnel immediately through the network system. Since long-term home care is typically involved, the parameters monitored must be analyzed and traced continuously over a long period of time. To minimize the intrusion to the patients, a wireless sensor embedded within a wireless network is highly recommended. To facilitate the widest possible use of various biochips, a smart sensor node concept was implemented. More specifically, various technologies and components such as built-in micro power generators, energy storage devices, initialization processes, no-waste bio-detection methodologies, embedded controllers, wireless warning signal transmissions, and power/data management were merged and integrated to create this novel technology. The design methodologies and the implementation schemes are detailed. Potential expansions of this newly developed technology to other applications regimes will be presented as well.
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