Dr. Marella De Angelis Profile

Dr. Marella De Angelis

at Istituto di Fisica Applicata "Nello Carrara"

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Author

Publications (20)

Proceedings Article | 9 December 2021 Paper

Label-free SERS/machine learning procedures for protein classification

Edoardo Farnesi, Andrea Barucci, Cristiano D'Andrea, Martina Banchelli, Chiara Amicucci, Marella de Angelis, Michael Schmitt, Paolo Matteini

Proceedings Volume 11920, 1192025 (2021) https://doi.org/10.1117/12.2615448

KEYWORDS: Proteins, Principal component analysis, Biological research, Statistical analysis, Data processing, Raman scattering, Photonics, Machine learning, Silver, Medicine

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SPIE Journal Paper | 2 July 2020 Open Access

Hollow core photonic crystal fiber-assisted Raman spectroscopy as a tool for the detection of Alzheimer’s disease biomarkers

Pinkie Eravuchira, Martina Banchelli, Cristiano D'Andrea, Marella De Angelis, Paolo Matteini, Israel Gannot

JBO, Vol. 25, Issue 07, 077001, (July 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.7.077001

KEYWORDS: Raman spectroscopy, Surface enhanced Raman spectroscopy, Photonic crystals, Alzheimer's disease, Proteins, Bioalcohols, Spectroscopy, Nanoparticles, Molecules

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Proceedings Article | 1 April 2020 Presentation

A SERS affinity bioassay based on ion-exchanged glass microrods (Conference Presentation)

Simone Berneschi, Cristiano D'Andrea, Ambra Giannetti, Marella De Angelis, Martina Banchelli, Andrea Barucci, Nadia Giovanna Boetti, Stefano Pelli, Francesco Baldini, Roberto Pini, Davide Janner, Diego Pugliese, Daniel Milanese, Paolo Matteini

Proceedings Volume 11361, 113610V (2020) https://doi.org/10.1117/12.2555817

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The well-known enhancement effect of surface-enhanced Raman spectroscopy (SERS) is associated with the presence of metallic nanostructures at the substrate surface. Different bottom-up and top-down processes have been proposed to impart the substrate with such a nanostructured layer. The former approaches are low cost but may suffer from reusability and stability. The latter strategies are expensive, time consuming and require special equipment that complicate the fabrication process. Here, we present the possibility to obtain stable and reusable SERS substrates by a low-cost silver-sodium ion-exchange process in soda-lime glass microrods. The microrods were obtained by cutting the tip of the ion-exchanged soda-lime fiber, resulting in disks of about few millimeters in length and one hundred microns in diameter. A thermal annealing post-process was applied to trigger the reduction of Ag+ ions into nanoparticles (AgNPs) within the ion-exchanged glass microrods. Afterwards, ion-exchange and thermal treatments were carefully tuned to assure the presence of silver NPs exposed on the surface of the microrods, without using any chemical etching. An AFM analysis confirmed the presence of AgNPs with size of tens of nm on the surface of the fiber probe. A SERS affinity bioassay was developed on the probe with the final aim of detecting microRNA fragments acting as biomarkers of different diseases. Specifically a DNA hybridization assay was built up by anchoring a molecular beacon containing a Raman tag on the Ag surface via thiol chemistry. Initial SERS experiments confirmed the presence of the beacon on the NPs embedded on the microrods surface, as monitored by detecting main spectral bands ascribed to the oligonucleotide chain. Finally, the ability of the platform to interact with the target microRNA sequence was assessed. The analysis was repeated on a number of miRNA sequences differing from the target to evaluate the specificity of the proposed assay.

Proceedings Article | 27 February 2019 Presentation + Paper

Fiber-enhanced Raman spectroscopy as a tool for an early detection of Alzheimer's disease biomarkers

P. Eravuchira, M. Banchelli, C. D'Andrea, M. De Angelis, P. Matteini, I. Gannot

Proceedings Volume 10872, 1087211 (2019) https://doi.org/10.1117/12.2516545

KEYWORDS: Raman spectroscopy, Alzheimer's disease, Spectroscopy, Raman scattering, Photonic crystal fibers, Liquids

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Proceedings Article | 13 February 2018 Paper

Plasmon-enhanced Raman detection of body-fluid components

Paolo Matteini, Martina Banchelli, Marella De Angelis, Cristiano D'Andrea, Roberto Pini

Proceedings Volume 10488, 104880W (2018) https://doi.org/10.1117/12.2295086

KEYWORDS: Raman spectroscopy, Surface enhanced Raman spectroscopy, Molecules, Plasmonics, Nanoparticles, Molecular assembly, Biological research, Biomedical optics

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Proceedings Article | 22 April 2016 Paper

Graphene oxide / plasmon nanoparticles bilayers for optimized SERS detection

M. Banchelli, M. de Angelis, R. Pini, B. Tiribilli, G. Caminati, P. Matteini

Proceedings Volume 9725, 97250Q (2016) https://doi.org/10.1117/12.2214623

KEYWORDS: Surface enhanced Raman spectroscopy, Graphene, Nanoparticles, Oxides, Silver, Plasmons, Plasmonics, Biosensing, Nanocomposites, Modulation, Magnesium, Raman spectroscopy, Adsorption, Coating, Molecules

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Proceedings Article | 15 March 2016 Paper

Optically induced microbubbles around gold nanorods: the influence of particle parameters and environment on cavitation threshold

Lucia Cavigli, Fulvio Ratto, Marella de Angelis, Sonia Centi, Sarah Lai, Alberto Cini, Claudia Borri, Stefano Colagrande, Roberto Pini

Proceedings Volume 9708, 970849 (2016) https://doi.org/10.1117/12.2212340

KEYWORDS: Cavitation, Nanorods, Photoacoustic imaging, Gold, Ultrasonography, Particles, Microsurgery, Biomedical optics, Cancer, Absorption, Diffusion, Thermography

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Proceedings Article | 7 March 2016 Presentation + Paper

Investigation on laser-assisted tissue repair with NIR millisecond-long light pulses and Indocyanine Green-biopolymeric patches

Paolo Matteini, Martina Banchelli, Maximilien Cottat, Iacopo Osticioli, Marella de Angelis, Francesca Rossi, Roberto Pini

Proceedings Volume 9702, 97020A (2016) https://doi.org/10.1117/12.2214621

KEYWORDS: Surgery, Laser welding, Near infrared, Photothermal effect, Optical fibers, Arteries, Laser tissue interaction, Collagen, Raman spectroscopy, Tissue optics, Tissues

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Proceedings Article | 11 March 2015 Paper

Bidimensional assemblies of nonspherical gold nanoparticles for SERS analysis of biomolecules

Paolo Matteini, Marella de Angelis, Lorenzo Ulivi, Sonia Centi, Roberto Pini

Proceedings Volume 9340, 93400S (2015) https://doi.org/10.1117/12.2078659

KEYWORDS: Surface enhanced Raman spectroscopy, Proteins, Nanoparticles, Gold, Biological research, Particles, Nanolithography, Nanostructures, Interfaces, Analytical research

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Proceedings Article | 11 March 2015 Paper

The influence of cellular uptake on the photostability and photoacoustic conversion efficiency of gold nanorods

Lucia Cavigli, Fulvio Ratto, Francesca Tatini, Paolo Matteini, Alberto Cini, Ilaria Giovannelli, Marella de Angelis, Francesca Rossi, Sonia Centi, Roberto Pini

Proceedings Volume 9323, 932346 (2015) https://doi.org/10.1117/12.2077632

KEYWORDS: Photoacoustic spectroscopy, Gold, Biomedical optics, Particles, Plasmons, Near infrared, Absorbance, Tissue optics, Transmission electron microscopy, Nanorods

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Proceedings Article | 14 June 2013 Paper

Photoacoustic stability of gold nanorods embedded in biopolymeric scaffolds

Lucia Cavigli, Marella De Angelis, Fulvio Ratto, Paolo Matteini, Francesca Rossi, Francesca Tatini, Sonia Centi, Roberto Pini

Proceedings Volume 8800, 88000E (2013) https://doi.org/10.1117/12.2032546

KEYWORDS: Photoacoustic spectroscopy, Biomedical optics, Gold, Particles, Absorption, Plasmons, Biomimetics, Nanoparticles, Tissue optics, Nanorods

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Proceedings Article | 4 March 2013 Paper

Optimization of the photoacoustic conversion of gold nanorods embedded in biopolymeric scaffolds

Lucia Cavigli, Marella De Angelis, Fulvio Ratto, Paolo Matteini, Francesca Rossi, Sonia Centi, Roberto Pini

Proceedings Volume 8581, 85810Z (2013) https://doi.org/10.1117/12.2003173

KEYWORDS: Photoacoustic spectroscopy, Gold, Biomedical optics, Particles, Absorption, Plasmons, Tissue optics, Biomimetics, Thermography, Nanorods

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Proceedings Article | 8 September 2005 Paper

High spatial resolution interferometric analysis of internal field in lithium niobate (LiNbO3)

M. Paturzo, D. Alfieri, S. Grilli, P. Ferraro, M. De Angelis, S. De Nicola, A. Finizio, P. De Natale, G. Pierattini

Proceedings Volume 5911, 591106 (2005) https://doi.org/10.1117/12.617068

KEYWORDS: Lithium niobate, Crystals, Interferometry, Digital holography, Spatial resolution, Lithium, Polarization, Electro optics, Holograms, Niobium

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Proceedings Article | 27 August 2005 Paper

Characterization and engineering of ferroelectric microstructures by interferometric methods

S. Grilli, P. Ferraro, M. Paturzo, D. Alfieri, P. De Natale, M. de Angelis, S. De Nicola, A. Finizio, G. Pierattini

Proceedings Volume 5858, 58580R (2005) https://doi.org/10.1117/12.613016

KEYWORDS: Digital holography, Crystals, Interferometry, Electro optics, Holograms, Lithium niobate, Holography, Semiconducting wafers, Scanning electron microscopy, Etching

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Proceedings Article | 22 October 2004 Paper

Investigation of internal electric field in LiNbO₃ crystal with two anti-parallel ferroelectric domains by interferometric technique

Melania Paturzo, Domenico Alfieri, Simonetta Grilli, Pietro Ferraro, Marella de Angelis, Sergio De Nicola, Lucia Sansone, Paolo De Natale, Giovanni Pierattini

Proceedings Volume 5560, (2004) https://doi.org/10.1117/12.560643

KEYWORDS: Crystals, Polarization, Digital holography, Phase measurement, Holograms, Interferometry, Electro optics, Interferometers, Lithium, Reflectivity

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Proceedings Article | 2 August 2004 Paper

Real-time phase-contrast analysis of domain switching in lithium niobate by digital holography

Simonetta Grilli, Pietro Ferraro, Marella de Angelis, Sergio De Nicola, Domenico Alfieri, Melania Paturzo, Paolo De Natale, Lucia Sansone, Giovanni Pierattini

Proceedings Volume 5531, (2004) https://doi.org/10.1117/12.560632

KEYWORDS: Digital holography, Electro optics, Switching, Lithium niobate, Interferometry, Refractive index, Polarization, Crystals, Visualization, Holography

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Proceedings Article | 30 May 2003 Paper

Interferometric analysis of a lithium niobate with engineering reversed domains

Marella de Angelis, Sergio De Nicola, Pietro Ferraro, Andrea Finizio, Simonetta Grilli, Giovanni Pierattini

Proceedings Volume 5144, (2003) https://doi.org/10.1117/12.501840

KEYWORDS: Crystals, Digital holography, Interferometry, Lithium niobate, Interferometers, Reflectivity, Diffraction, Holographic interferometry, Semiconducting wafers, Interfaces

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Proceedings Article | 23 October 2001 Paper

Two-beam shearing interferometric method for testing a conical lens

Marella De Angelis, Sergio De Nicola, Pietro Ferraro, Andrea Finizio, Giovanni Pierattini

Proceedings Volume 4398, (2001) https://doi.org/10.1117/12.445555

KEYWORDS: Axicons, Interferometry, Wavefronts, Optical components, Optical testing, Spherical lenses, Fringe analysis, Shearing interferometers, Interferometers, Laser beam diagnostics

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Proceedings Article | 17 August 1999 Paper

Fringe analysis of moire interferometry for studying micromechanical behavior of composite materials

Sergio De Nicola, Pietro Ferraro, Andrea Finizio, Giovanni Pierattini, Marella De Angelis

Proceedings Volume 3745, (1999) https://doi.org/10.1117/12.357788

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Proceedings Article | 30 April 1993 Paper

Narrow linewidth visible diode laser at 690 nm: spectroscopy of the SrI intercombination line

Francesco Pavone, G. Giusfredi, Annalisa Capanni, Massimo Inguscio, Guglielmo Tino, Marella De Angelis

Proceedings Volume 1837, (1993) https://doi.org/10.1117/12.143689

KEYWORDS: Semiconductor lasers, Strontium, Spectroscopy, Visible radiation, Signal detection, Diodes, Absorption, Laser stabilization, Argon, Doppler effect

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