Dr. Jeffrey A. Ketterling Profile

Dr. Jeffrey A. Ketterling

Associate Research Director at Riverside Research

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Publications (9)

Proceedings Article | 20 March 2015 Paper

Optical characterization of vitreous structure in health and disease

Ashwin Sampathkumar, Matin Khoshnevis, Jeffrey Ketterling, Jerry Sebag

Proceedings Volume 9307, 930714 (2015) https://doi.org/10.1117/12.2080543

KEYWORDS: Vitreous, Scattering, Gold, Light scattering, Opacity, Nanoparticles, Optical spheres, Spherical lenses, Absorption, Spectroscopy

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Patients with myopic vitreopathy (MV) and posterior vitreous detachment (PVD) see floaters, which often can degrade contrast sensitivity to a significant extent. The floaters are associated with irregularly shaped vitreous opacities. In contrast, asteroid hyalosis (AH), which is characterized by microscopic, spherical, white asteroid bodies (ABs) that move with vitreous displacement during eye movements, does not interfere significantly with vision. We hypothesize that the irregular surface of vitreous opacities associated with MV distinguish MV from AH and its smooth-surfaced ABs. A finite-element model was developed to characterize the light-scattering field of vitreous opacities in MV and AH. Vitreous opacities were modeled as spherical bodies and illuminated by a plane wave of light in the optical wavelength of 400-1000 nm. The model has provisions to add random perturbations to the spherical surfaces to vary light-scattering properties and mimic disturbances in vision from simple diffraction rings to more-complex patterns. Samples of ex vivo porcine vitreous (0.4-0.5 ml) were placed in a custom spectrophotometer and the static, light-scattering field of the sample was measured in the spectral range of 400-1000 nm with a resolution of 0.3 nm. Model solutions mimicking healthy vitreous and AH were experimentally validated using a laboratory optical apparatus. Model-based estimates of scattering cross-sections of calibrated gold nanoparticles were found to be in good agreement with experimental measurements. Simulation results potentially can complement experimental data to quantitatively characterize vitreous opacities and distinguish between structures that significantly impact vision, such as those due to myopic vitreopathy and aging, from those that have little impact, like ABs. Such techniques to determine the structural significance of vitreous opacification would be very useful in selecting patients for surgery as well as evaluating the efficacy of experimental therapies for floaters.

Proceedings Article | 23 February 2012 Paper

Combined optoacoustic and high frequency ultrasound imaging of live mouse embryos

Parag Chitnis, Orlando Aristizbal, Erwan Filoux, Ashwinkumar Sampathkumar, Jonathan Mamou, Daniel Turnbull, Jeffrey Ketterling

Proceedings Volume 8223, 822314 (2012) https://doi.org/10.1117/12.908716

KEYWORDS: Brain, Transducers, Head, Ultrasonography, Visualization, Image segmentation, Data acquisition, Neuroimaging, Magnetic resonance imaging, In vivo imaging

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Proceedings Article | 26 March 2011 Paper

Pad-printed thick-film transducers for high-frequency and high-power applications

Wanda Wolny, Jeffrey Ketterling, Franck Levassort, Rasmus Lou-Moeller, Erwan Filoux, Jonathan Mamou, Ronald Silverman, Marc Lethiecq

Proceedings Volume 7968, 79681C (2011) https://doi.org/10.1117/12.878230

KEYWORDS: Transducers, Optical spheres, Acoustics, Electrodes, In vivo imaging, Ferroelectric materials, Heart, Eye, Ultrasonography, Medical imaging

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Proceedings Article | 12 April 2005 Paper

Prostate elastography: preliminary in vivo results

S. Alam, E. Feleppa, A. Kalisz, S. Ramchandran, R. Ennis, Frederick Lizzi, C.-S. Wuu, Jeffrey Ketterling

Proceedings Volume 5750, (2005) https://doi.org/10.1117/12.596788

KEYWORDS: Prostate, Elastography, Prostate cancer, Biopsy, Tissues, Cancer, Data acquisition, In vivo imaging, Ultrasonography, Scanners

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Proceedings Article | 12 April 2005 Paper

High-frequency harmonic imaging of the eye

Ronald Silverman, D. Jackson Coleman, Jeffrey Ketterling, Frederic Lizzi

Proceedings Volume 5750, (2005) https://doi.org/10.1117/12.595412

KEYWORDS: Transducers, Eye, Image segmentation, Ultrasonography, Vitreous, Image resolution, Optical coherence tomography, Retina, Tissues, Acoustics

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Proceedings Article | 28 April 2004 Paper

Ultrasonic tissue-type imaging (TTI) for planning treatment of prostate cancer

Ernest Feleppa, Jeffrey Ketterling, Christopher Porter, John Gillespie, Cheng-Shie Wuu, Stella Urban, Andrew Kalisz, Ronald Ennis, Peter Schiff

Proceedings Volume 5373, (2004) https://doi.org/10.1117/12.543632

KEYWORDS: Biopsy, Tissues, Cancer, Prostate, Ultrasonography, Ultrasonics, 3D image processing, Prostate cancer, Acoustics, Magnetic resonance imaging

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Proceedings Article | 28 April 2004 Paper

Relationship of 2D ultrasonic spectral parameters to the physical properties of soft tissue scatterers

Tian Liu, Frederic Lizzi, Jeffrey Ketterling, Paul Lee, Andrew Kalisz, Ronald Silverman, Gerald Kutcher

Proceedings Volume 5373, (2004) https://doi.org/10.1117/12.535836

KEYWORDS: Transducers, Tissues, Spatial frequencies, Spectrum analysis, Ultrasonics, Ultrasonography, Acoustics, Data acquisition, Integration, Medical research

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Proceedings Article | 11 April 2002 Paper

Novel methods of analyzing radio-frequency echo signals for the purpose of imaging brachytherapy seeds used to treat prostate cancer

Ernest Feleppa, Sarayu Ramachandran, Sheikh Alam, Andrew Kalisz, J. Ketterling, Ronald Ennis, Cheng-Shie Wuu

Proceedings Volume 4687, (2002) https://doi.org/10.1117/12.462146

KEYWORDS: Prostate, Ultrasonography, Transducers, Tissues, Liver, Signal analyzers, Prostate cancer, Doppler effect, Computed tomography, Data acquisition

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Proceedings Article | 30 May 2001 Paper

Prostate imaging based on rf spectrum analysis and nonlinear classifiers for guiding biopsies and targeting radiotherapy

Ernest Feleppa, J. Ketterling, Andrew Kalisz, Stella Urban, C. Porter, John Gillespie, Peter Schiff, Ronald Ennis, Cheng-Shie Wuu, Judd Moul, Isabell Sesterhenn, P. Scardino

Proceedings Volume 4325, (2001) https://doi.org/10.1117/12.428213

KEYWORDS: Biopsy, Prostate, Tissues, Cancer, Radiotherapy, Spectrum analysis, Ultrasonography, Ultrasonics, Biological research, Prostate cancer

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Showing 5 of 9 publications

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