Discoid Lupus Erythematosus is chronic autoimmune disease that disproportionately affects parts of the population. Presently, the biochemical events involved in the formation of the disease and elements of the pathophysiology are poorly understood, demonstrating a need for improved analysis. We present the results of our multimodal imaging combining Raman spectroscopy and mass spectrometry and their chemometric analysis and models. We distinguish physiological features and how they differ between healthy and DLE. We show that by fusing the data we are able to build a classification model that can differentiate the two with higher accuracy than either technique alone. The findings from this study can serve as a basis for improved biomedical diagnostics and better informed potential treatment options.
Discoid Lupus Erythematosus is a dermatological disease difficult to diagnose. By using Raman spectroscopy and MALDI mass spectrometry a shift in lipid biochemistry has been identified relative to healthy tissue, that can improve early detection.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.