Prof. George A. Stanciu Profile

Prof. George A. Stanciu

Director/CMMIP at Univ Politehnica Bucuresti

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Publications (9)

SPIE Journal Paper | 20 January 2023 Open Access

Toward augmenting tip-enhanced nanoscopy with optically resolved scanning probe tips

Jeremy Belhassen, Simcha Glass, Eti Teblum, George Stanciu, Denis E. Tranca, Zeev Zalevsky, Stefan Stanciu, Avi Karsenty

APN, Vol. 2, Issue 02, 026002, (January 2023) https://doi.org/10.1117/12.10.1117/1.APN.2.2.026002

KEYWORDS: Absorption, Gold, Scattering, Optical properties, Plasmons, Super resolution microscopy, Atomic force microscopy, Light sources and illumination, Simulations, Photonics

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Proceedings Article | 3 October 2019 Paper

Quantitative imaging of advanced nanostructured materials with scattering-type scanning near field optical microscopy

Stefan Stanciu, Denis Tranca, Laura Pastorino, Stefania Boi, Young Min Song, Young Jin Yoo, Satoshi Ishii, Fang Yang, Aiguo Wu, Radu Hristu, George Stanciu

Proceedings Volume 11207, 112071K (2019) https://doi.org/10.1117/12.2527401

KEYWORDS: Dielectrics, Optical coatings, Near field scanning optical microscopy, Near field optics, Nanostructuring, Toxic industrial chemicals, Optical microscopy, Nanoparticles, Optical properties, Biosensing

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Proceedings Article | 14 February 2018 Presentation + Paper

Multispectral detection of cutaneous lesions using spectroscopy and microscopy approaches

E. Borisova, Ts. Genova-Hristova, P. Troyanova, E. Pavlova, I. Terziev, O. Semyachkina-Glushkovskaya, M. Lomova, E. Genina, G. Stanciu, D. Tranca, L. Avramov

Proceedings Volume 10467, 104670M (2018) https://doi.org/10.1117/12.2289119

KEYWORDS: Skin, Tissues, Diagnostics, Spectroscopy, Pathology, Tissue optics, Luminescence, Reflectivity, Microscopy

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Proceedings Article | 5 January 2017 Paper

Nonlinear optical microscopy for investigation of gastrointestinal lesions

Ts. Genova, E. Borisova, G. Stanciu, D. Tranca, I. Terziev, N. Penkov, B. Vladimirov, M. Lomova, O. Semyachkina-Glushkovskaya, L. Avramov

Proceedings Volume 10226, 1022617 (2017) https://doi.org/10.1117/12.2260712

KEYWORDS: Tissues, Microscopy, Second-harmonic generation, Collagen, Diagnostics, Luminescence, Biopsy, Cancer, Tissue optics, Statistical analysis

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The standard procedure for cancer detection includes rigorous biopsy protocols, which are costly and time consuming; also the accuracy of the current diagnostic procedure relays entirely on the physician’s experience and it is limited by the high probability of miss rates. Therefore new sensitive diagnostic modalities for analysis of biopsy tissue samples or on site, in vivo microscopy tissue examination, are necessary.

In this study we present an investigation using nonlinear microscopy techniques for histological sections from biopsy tissue samples analysis. The samples were routinely processed for histological analysis and during the standard sampling the tissue slices were stained with hematoxylin and eosin dyes.

The application of nonlinear microscopy techniques, such as two photon excitation fluorescence microscopy and second harmonic generation microscopy in biomedical research for cancer diagnosis has been vastly expanding in the last few years. Two-photon excitation fluorescence microscopy is based on a non-linear optical effect of simultaneously absorption of two photons, thus achieves excited state of the absorbing molecule with energy corresponding to the sum of the energies of two incident photons. This method allows for using an excitation wavelength which is double the typically required one for excitation of diagnostically valuable endogenous fluorophores. This results in more efficient depth penetration of the longer wavelength light in the tissue. The second harmonic generation microscopy is based on the principle of the non-linear susceptibility in noncentrosymmetric structures; such structures in the tissue are formed mainly by the collagen fibers. After excitation with near-infrared photons with wavelength λ of the collagen structures, photons with wavelength ½ λ are emitted — this corresponding to the second harmonic of the excitation beam’s frequency.

The applied nonlinear microscopy techniques are suitable for detection and quantification of the morphological changes associated with stroma and epithelial transformation in colon cancer, providing complementary information about the tissue microstructure and displaying distinctive patterns between normal and malignant human colon tissues.

Proceedings Article | 7 May 2007 Paper

Nanometrology of microsystems: traceability problem in nanometrology

Iuliana Iordache, D. Apostol, O. Iancu, G. Stanciu, P. Logofatu, V. Damian, F. Garoi, B. Savu, M. Bojan

Proceedings Volume 6635, 663503 (2007) https://doi.org/10.1117/12.741833

KEYWORDS: Interferometers, Calibration, Metrology, Interferometry, Fringe analysis, Ferroelectric materials, Standards development, Light sources, Microelectromechanical systems, Laser stabilization

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Proceedings Article | 25 April 2007 Paper

Study of hydroxyl carbonate apatite formation on bioactive glass coated dental ceramics by confocal laser scanning microscopy (CLSM)

G. Stanciu, B. Savu, I. Sandulescu, K. Paraskevopoulos, P. Koidis

Proceedings Volume 6606, 66061K (2007) https://doi.org/10.1117/12.730204

KEYWORDS: Apatite, Ceramics, Glasses, Carbonates, Confocal microscopy, Chemical analysis, Bone, Ions, Calcium, Bioglass

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Proceedings Article | 2 July 1998 Paper

Investigation of HgBrxI2-x using confocal laser scanning microscopy and x-ray diffraction

George Stanciu, J. Oud, E. Polychronyadis, Maria Daviti, Angelia Stanciu, Catalin Miu

Proceedings Volume 3405, (1998) https://doi.org/10.1117/12.312758

KEYWORDS: Crystals, Chemical analysis, Luminescence, Laser scanners, Sensors, Confocal microscopy, Scanning electron microscopy, X-ray diffraction, Microscopes, Semiconductors

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Proceedings Article | 14 September 1994 Paper

Display and analysis of 2D and 3D images obtained on semiconductor devices using a laser scanner

George Stanciu, Catalin Miu, Sergiu Stejar

Proceedings Volume 2337, (1994) https://doi.org/10.1117/12.186632

KEYWORDS: Semiconductors, 3D image processing, Laser scanners, 3D displays, Photodiodes, Image processing, 3D scanning, Semiconductor lasers, Microscopes, Electromagnetism

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Proceedings Article | 4 April 1994 Paper

3D images used in the localization of the defects in semiconductor devices

George Stanciu, Catalin Miu, Sergiu Stejar

Proceedings Volume 2184, (1994) https://doi.org/10.1117/12.172086

KEYWORDS: Photodiodes, 3D image processing, Semiconductors, 3D scanning, Laser scanners, Microscopy, Microcontrollers, Diodes, Diffusion, Optical microscopy

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