Francesca Rossi main interest concerns light-tissue interactions. Her current research focuses on the design of innovative medical devices, in collaboration with medical doctors and photonics companies. Light-based devices are opening a new frontier in the medical field as they may be used to induce several effects on tissues, allowing to design new surgical, therapeutic and diagnostic approaches in a variety of fields (e.g. Ophthalmology, Dermatology, and Neurosurgery). In this framework, she is the scientific coordinator of Regional, National and European projects. She authored over than 120 scientific publications. She is also inventor of 8 patents. She is currently Researcher at the Institute of Applied Physics “Nello Carrara”, of the Italian National Research Council. She is also actively involved in innovation transfer activities in the framework of regional and national projects, and coordinator of the awareness node for CNR Florence in the national Competence Center Artes 4.0. She is the Italian contact point of two European CSA projects (FP7 OASIS, H2020 EPRISE), to support photonics companies in the Life Science in the innovation and internationalization pathway.
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In this context, plasmonic particles as gold nanorods are achieving resounding interest, owing to their efficiency of photothermal conversion, intense optical absorbance in the near infrared region, inertness in the body and convenience for conjugation with ligands of molecular targets.
On the other hand, the photoinstability of plasmonic particles remains a remarkable obstacle. In particular, gold nanorods easily reshape into nanospheres and so lose their optical absorbance in the near infrared region, under exposure to few-ns-long laser pulses. This issue is attracting much attention and stimulating ad-hoc solutions, such as the addition of rigid shells and the optimization of multiple parameters.
In this contribution, we focus on the influence of the shape of gold nanorods on their photothermal behavior and photostability. We describe the photothermal process in the gold nanorods by modeling their optical absorption and consequent temperature dynamics as a function of their aspect ratio (length / diameter).
Our results suggest that increasing the aspect ratio does probably not limit the photostability of gold nanorods, while shifting the plasmonic peak towards wavelengths around 1100 nm, which hold more technological interest.
Vocal folds and dura mater were harvested from 9-months old porks and used in the experimental sessions within 4 hours after sacrifice.
In vocal folds treatment, an IdocyanineGreen-infused chitosan patch was applied onto the anterior commissure, while the dura mater was previously incised and then bonded. A diode laser emitting at 810 nm, equipped with a 600 μm diameter optical fiber was used to weld the patch onto the tissue, by delivering single laser spots to induce local patch/tissue adhesion. The result is an immediate adhesion of the patch to the tissue. Standard histology was performed, in order to study the induced photothermal effect at the bonding sites. This preliminary experimental activity shows the advantages of the proposed technique in respect to standard surgery: simplification of the procedure; decreased foreign-body reaction; reduced inflammatory response; reduced operating times and better handling in depth.
In this contribution we present an investigation of the photostability of gold nanorods embedded in biomimetic scaffolds by means of photoacustic experiments.
Experimental and model analysis on the temperature dynamics during diode laser welding of the cornea
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