Our ability to study large quantities of synapses at the single synapse resolution has expanded over the last few years. For example, methods allow the study of +100 million synapses across an entire sagittal section of the mouse brain (Zhu et al, Neuron, 2018) using confocal microscopy or +10.000 synapses in mouse hippocampus CA1 using electron microscopy (Santuy et al., Sci Rep, 2020), showing a remarkable diversity of synapse types across brain regions. Furthermore, developments of e.g. genetically encoded fluorescent proteins or calcium indicators as well as novel super-resolution microscopy opens up the possibility of observing synaptic structure and function in vivo. In this session, we will discuss what these new methods tell us about synapses and hence about brain structure and function.
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