The miniaturization of analytical systems ultimately targets sample-in/result-out systems for the complete analysis of biological samples. Besides the enhanced performance of those systems - namely combining sample preparation, biological reaction, and the detection itself in one device - miniaturization enables the construction of portable systems for on-site analysis of suspicious samples. This course will provide a broad overview of the underlying technologies enabling the realization of a miniaturized integrated biological lab. It starts with the history over two decades of microfluidics and goes on to describe the fabrication technologies for miniaturized devices. The main focus is the application of microfluidic components in biotechnology (e.g. separation techniques, PCR, Lab-on-a-Chip etc.) and chemistry (e.g. micro reactors, micro mixers etc.), leading finally to the challenges in their use for mobile detection of biological pathogens. Guidelines for the efficient development of microfluidic devices for mobile detection of biological agents will be presented, based on the microfluidic tool box concept. Finally, some hands-on tests with microfluidic devices will give the attendee an opportunity to get in touch with this novel technology.

This course will provide a broad overview on all aspects of micro- and nanofluidic technology starting with the history over one decade of microfluidics and describing the various fabrication technologies for miniaturized devices in polymers, glass, silicon and metals. A main focus is the application of microfluidic components in biotechnology (e.g. separation techniques, PCR, Lab-on-a-Chip etc.) and chemistry (e.g. micro reactors, micro mixers etc.) and a special microfluidic tool box suited for these applications. Commercialization strategies and business models of microfluidic companies will be covered as well as the hot topics of "killer applications", and the need for standardization. The aspect of becoming even smaller and the challenges and limitations of nanofluidics will have a special focus. The course will conclude with hands-on tests using microfluidic devices, including a water and milk analysis with chip based capillary electrophoresis.