Prof. Andrew K. Dunn Profile

Prof. Andrew K. Dunn

Professor at The Univ. of Texas at Austin

SPIE Involvement:

Author

Publications (59)

Proceedings Article | 12 March 2024 Presentation + Paper

Non-degenerate two-photon imaging of deep rodent cortex using indocyanine green in the water absorption window

Alankrit Tomar, Shaun Engelmann, Aaron Woods, Andrew Dunn

Proceedings Volume 12847, 128470A (2024) https://doi.org/10.1117/12.3000564

KEYWORDS: Dyes, Absorption, Photons, Indocyanine green, Light absorption, In vivo imaging, Two photon imaging, Pulse signals, Microscopes

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Proceedings Article | 12 March 2024 Presentation + Paper

Multi-exposure speckle imaging through an optical fiber bundle

Logan Parker, Qingwei Fang, Andrew Dunn, James Tunnell

Proceedings Volume 12856, 1285604 (2024) https://doi.org/10.1117/12.3003394

KEYWORDS: Printed circuit board testing, Free space, Microfluidics, Laser speckle contrast imaging, Speckle, Beam path, Speckle pattern, Speckle imaging, Optical fibers, Cameras

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SPIE Journal Paper | 6 November 2023 Open Access

Pulse train gating to improve signal generation for in vivo two-photon fluorescence microscopy

Shaun A. Engelmann, Alankrit Tomar, Aaron L. Woods, Andrew K. Dunn

NPh, Vol. 10, Issue 04, 045006, (November 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.4.045006

KEYWORDS: Pulse signals, Education and training, In vivo imaging, Signal generators, Signal to noise ratio, Ultrafast phenomena, Two photon excitation microscopy, Imaging systems, Electrooptic modulation, Neurophotonics

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SPIE Journal Paper | 11 March 2023 Open Access

Using pressure-driven flow systems to evaluate laser speckle contrast imaging

Colin T. Sullender, Adam Santorelli, Lisa M. Richards, Pawan K. Mannava, Christopher Smith, Andrew K. Dunn

JBO, Vol. 28, Issue 03, 036003, (March 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.3.036003

KEYWORDS: Laser speckle contrast imaging, Microfluidics, Sensors, Imaging systems, Laser systems engineering, Equipment, Control systems, Speckle, Cameras, Reproducibility

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Proceedings Article | 7 March 2023 Presentation + Paper

Impact of logarithmic and linear spaced camera exposure durations for multi-exposure speckle imaging

Adam Santorelli, Christopher Smith, Andrew Dunn

Proceedings Volume 12378, 1237803 (2023) https://doi.org/10.1117/12.2648443

KEYWORDS: Cameras, Speckle, Microfluidics, Laser speckle contrast imaging, Speckle imaging, Imaging systems, Sensors, Time metrology, Dynamic light scattering

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Proceedings Article | 6 March 2023 Presentation + Paper

Intraoperative laser speckle contrast imaging to visualize blood flow dynamics in neurosurgery

Alexis Dimanche, David Miller, Johannes Goldberg, Cedric Kissling, Timothy Müller, Mandy Müller, Michael Murek, David Bervini, Andreas Raabe, Andrew Dunn

Proceedings Volume 12368, 1236804 (2023) https://doi.org/10.1117/12.2647911

KEYWORDS: Laser speckle contrast imaging, Surgery, Blood circulation, Speckle, Microscopes, Neurosurgery, Visualization, Aneurysms

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SPIE Journal Paper | 31 March 2022 Open Access

High-resolution three-dimensional blood flow tomography in the subdiffuse regime using laser speckle contrast imaging

Chakameh Jafari, Samuel Mihelic, Shaun Engelmann, Andrew Dunn

JBO, Vol. 27, Issue 08, 083011, (March 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.8.083011

KEYWORDS: Reconstruction algorithms, Blood circulation, Speckle, Sensors, 3D modeling, Tomography, Tissues, Capillaries, Laser speckle contrast imaging, Computer simulations

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Significance: Visualizing high-resolution hemodynamics in cerebral tissue over a large field of view (FOV), provides important information in studying disease states affecting the brain. Current state-of-the-art optical blood flow imaging techniques either lack spatial resolution or are too slow to provide high temporal resolution reconstruction of flow map over a large FOV. Aim: We present a high spatial resolution computational optical imaging technique based on principles of laser speckle contrast imaging (LSCI) for reconstructing the blood flow maps in complex tissue over a large FOV provided that the three-dimensional (3D) vascular structure is known or assumed. Approach: Our proposed method uses a perturbation Monte Carlo simulation of the high-resolution 3D geometry for both accurately deriving the speckle contrast forward model and calculating the Jacobian matrix used in our reconstruction algorithm to achieve high resolution. Given the convex nature of our highly nonlinear problem, we implemented a mini-batch gradient descent with an adaptive learning rate optimization method to iteratively reconstruct the blood flow map. Specifically, we implemented advanced optimization techniques combined with efficient parallelization and vectorization of the forward and derivative calculations to make reconstruction of the blood flow map feasible with reconstruction times on the order of tens of minutes. Results: We tested our reconstruction algorithm through simulation of both a flow phantom model as well as an anatomically correct murine cerebral tissue and vasculature captured via two-photon microscopy. Additionally, we performed a noise study, examining the robustness of our inverse model in presence of 0.1% and 1% additive noise. In all cases, the blood flow reconstruction error was <2 % for most of the vasculature, except for the peripheral vasculature which suffered from insufficient photon sampling. Descending vasculature and deeper structures showed slightly higher sensitivity to noise compared with vasculature with a horizontal orientation at the more superficial layers. Our results show high-resolution reconstruction of the blood flow map in tissue down to 500 μm and beyond. Conclusions: We have demonstrated a high-resolution computational imaging technique for visualizing blood flow map in complex tissue over a large FOV. Once a high-resolution structural image is captured, our reconstruction algorithm only requires a few LSCI images captured through a camera to reconstruct the blood flow map computationally at a high resolution. We note that the combination of high temporal and spatial resolution of our reconstruction algorithm makes the solution well-suited for applications involving fast monitoring of flow dynamics over a large FOV, such as in functional neural imaging.

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SPIE Journal Paper | 7 March 2022 Open Access

Continuous blood flow visualization with laser speckle contrast imaging during neurovascular surgery

David Miller, Ramsey Ashour, Colin Sullender, Andrew Dunn

NPh, Vol. 9, Issue 02, 021908, (March 2022) https://doi.org/10.1117/12.10.1117/1.NPh.9.2.021908

KEYWORDS: Laser speckle contrast imaging, Blood circulation, Microscopes, Aneurysms, Surgery, Visualization, Video, Cameras, Veins, Luminescence

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Proceedings Article | 4 March 2022 Presentation + Paper

Intraoperative real-time and continuous cerebral blood flow visualization with laser speckle contrast imaging

David Miller, Ramsey Ashour, Colin Sullender, Andrew Dunn

Proceedings Volume 11945, 1194502 (2022) https://doi.org/10.1117/12.2608914

KEYWORDS: Laser speckle contrast imaging, Microscopes, Visualization, Surgery, Aneurysms, Speckle, Cerebral blood flow, Blood circulation, Semiconductor lasers, Reflectivity

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Proceedings Article | 4 March 2022 Presentation + Paper

Longitudinal multiphoton microscopy of neural structure using a diamond Raman laser and Yb fiber amplifier

Shaun Engelmann, Samuel Mihelic, Annie Zhou, Ahmed Hassan, Michael Williamson, Andrew Dunn

Proceedings Volume 11991, 1199104 (2022) https://doi.org/10.1117/12.2610074

KEYWORDS: Diamond, Ytterbium, Fiber amplifiers, Fiber lasers, Imaging systems, Neurons, Multiphoton microscopy, Microscopes, Laser systems engineering

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Proceedings Article | 9 March 2020 Presentation

longitudinal multimodal mapping of neural activity and blood flow reveals neurovascular dissociations in an awake mouse model of microinfarcts (Conference Presentation)

Fei He, Colin Sullender, Hanlin Zhu, Theresa Jones, Chong Xie, Andrew Dunn, Lan Luan

Proceedings Volume 11226, 1122618 (2020) https://doi.org/10.1117/12.2546187

KEYWORDS: Brain mapping, Mouse models, Blood circulation, Brain, Cerebral blood flow, Hemodynamics, Nanoelectronics, Tissue optics, Optical imaging, Imaging systems

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Proceedings Article | 19 February 2020 Presentation + Paper

Rapid assessment of skin surgical margins using superpixel Raman spectroscopic imaging

Xu Feng, Matthew Fox, Jason Reichenberg, Fabiana C. P. Lopes, Katherine Sebastian, Andrew Dunn, Mia Markey, James Tunnell

Proceedings Volume 11222, 1122205 (2020) https://doi.org/10.1117/12.2546191

KEYWORDS: Raman spectroscopy, Confocal microscopy, Skin cancer, Optical spectroscopy imaging, Mohs surgery, Tissue optics

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Proceedings Article | 1 March 2019 Presentation + Paper

Computational speckle contrast optical tomography

David Miller, Chakameh Jafari, Colin Sullender, Samuel Mihelic, Ahmed Hassan, Andrew Dunn

Proceedings Volume 10877, 1087707 (2019) https://doi.org/10.1117/12.2512456

KEYWORDS: Monte Carlo methods, Brain, Laser speckle contrast imaging, Speckle, Scattering, Blood circulation, Neurons, Tissue optics, Dynamic light scattering, Visualization, Brain-machine interfaces, Optical imaging, Neuroimaging

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SPIE Journal Paper | 27 July 2018 Open Access

Imaging of cortical oxygen tension and blood flow following targeted photothrombotic stroke

Colin Sullender, Andrew Mark, Taylor Clark, Tatiana Esipova, Sergei Vinogradov, Theresa Jones, Andrew Dunn

NPh, Vol. 5, Issue 03, 035003, (July 2018) https://doi.org/10.1117/12.10.1117/1.NPh.5.3.035003

KEYWORDS: Oxygen, Blood circulation, Mercury, Laser speckle contrast imaging, Digital micromirror devices, Phosphorescence, Imaging systems, Speckle, Brain, Veins

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Proceedings Article | 23 February 2018 Paper

Polymer dots enable deep in vivo multiphoton fluorescence imaging of cerebrovascular architecture

Ahmed Hassan, Xu Wu, Jeremy Jarrett, Shihan Xu, David Miller, Jiangbo Yu, Evan Perillo, Yen-Liang Liu, Daniel Chiu, Hsin-Chih Yeh, Andrew Dunn

Proceedings Volume 10498, 104982Y (2018) https://doi.org/10.1117/12.2290404

KEYWORDS: Polymers, In vivo imaging, Absorption, Scattering, Multiphoton fluorescence microscopy, Semiconductors

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Proceedings Article | 23 February 2018 Presentation + Paper

In vivo, two-color multiphoton microscopy using a femtosecond diamond Raman laser

Jeremy Jarrett, Evan Perillo, Ahmed Hassan, David Miller, Andrew Dunn

Proceedings Volume 10498, 104981V (2018) https://doi.org/10.1117/12.2289299

KEYWORDS: Diamond, Raman spectroscopy, In vivo imaging, Fiber lasers, Fiber amplifiers, Microscopes, Mirrors, Multiphoton microscopy, Imaging systems, Laser systems engineering

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Proceedings Article | 19 April 2017 Presentation

Multi-exposure speckle imaging of cerebral blood flow: a pilot clinical study (Conference Presentation)

Lisa Richards, S. M. Kazmi, Katherine Olin, James Waldron, Douglas Fox, Andrew Dunn

Proceedings Volume 10063, 1006309 (2017) https://doi.org/10.1117/12.2251020

KEYWORDS: Laser speckle contrast imaging, Speckle imaging, Cerebral blood flow, Ischemia, Optical imaging, Blood circulation, Image resolution, Light sources, Imaging systems, Cameras

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Proceedings Article | 21 February 2017 Presentation + Paper

In vivo multiphoton microscopy beyond 1 mm in the brain

David Miller, Flor Medina, Ahmed Hassan, Evan Perillo, Kristen Hagan, S. M. Shams Kazmi, Boris Zemelman, Andrew Dunn

Proceedings Volume 10069, 100690C (2017) https://doi.org/10.1117/12.2249949

KEYWORDS: Multiphoton microscopy, In vivo imaging, Two photon excitation microscopy, Tissue optics, Brain, Optical amplifiers, Indocyanine green, Two photon imaging, Brain imaging, Sapphire, Neurons, Luminescence, Oscillators, Microscopes, 3D image reconstruction

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Proceedings Article | 26 April 2016 Presentation

Quantification of volumetric cerebral blood flow using hybrid laser speckle contract and optical coherence tomography (Conference Presentation)

Niksa Valim, Andrew Dunn

Proceedings Volume 9707, 97070F (2016) https://doi.org/10.1117/12.2214771

KEYWORDS: Blood circulation, Blood, Laser speckle contrast imaging, Imaging systems, Optical coherence tomography, Cerebral blood flow, Speckle, Visualization, Capillaries, Near infrared

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Proceedings Article | 9 March 2015 Paper

Computational modeling of STED microscopy through multiple biological cells under one- and two-photon excitation

Andrew Mark, Mitchell Davis, Matthew Starosta, Andrew Dunn

Proceedings Volume 9330, 93300V (2015) https://doi.org/10.1117/12.2078345

KEYWORDS: Point spread functions, Stimulated emission depletion microscopy, Electroluminescent displays, Microscopy, Scattering, Optical simulations, Laser scattering, Finite-difference time-domain method, Signal detection, 3D modeling

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Proceedings Article | 9 March 2015 Paper

Single particle tracking through highly scattering media with multiplexed two-photon excitation

Evan Perillo, Yen-Liang Liu, Cong Liu, Hsin-Chih Yeh, Andrew Dunn

Proceedings Volume 9331, 933107 (2015) https://doi.org/10.1117/12.2079897

KEYWORDS: Particles, Microscopes, Multiplexing, Temporal resolution, Scattering, 3D modeling, Molecules, Confocal microscopy, Scattering media, Light scattering

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SPIE Journal Paper | 18 August 2014 Open Access

Intraoperative laser speckle contrast imaging with retrospective motion correction for quantitative assessment of cerebral blood flow

Lisa Richards, Erica Towle, Douglas Fox, Andrew Dunn

NPh, Vol. 1, Issue 01, 015006, (August 2014) https://doi.org/10.1117/12.10.1117/1.NPh.1.1.015006

KEYWORDS: Laser speckle contrast imaging, Image registration, Electrocardiography, Speckle, Image filtering, Tissues, Cameras, Microscopes, Blood circulation, Visualization

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SPIE Journal Paper | 4 August 2014 Open Access

Imaging depth and multiple scattering in laser speckle contrast imaging

Mitchell Davis, S. M. Shams Kazmi, Andrew Dunn

JBO, Vol. 19, Issue 08, 086001, (August 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.8.086001

KEYWORDS: Scattering, Laser speckle contrast imaging, Monte Carlo methods, Multiple scattering, Laser scattering, Tissues, Photon transport, Natural surfaces, Signal detection, Speckle

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Proceedings Article | 4 March 2014 Paper

3D single-molecule tracking using one- and two-photon excitation microscopy

Cong Liu, Evan Perillo, Quincy Zhuang, Khang Huynh, Andrew Dunn, Hsin-Chih Yeh

Proceedings Volume 8950, 89501C (2014) https://doi.org/10.1117/12.2039565

KEYWORDS: Molecules, Monte Carlo methods, Sensors, Microscopes, Luminescence, Objectives, Confocal microscopy, Two photon excitation microscopy, Cameras, Fluorescence spectroscopy

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Proceedings Article | 4 March 2014 Paper

Enhanced 3D localization of individual RNA transcripts via astigmatic imaging

Evan Perillo, Leyma De Haro, Mary Phipps, Jennifer Martinez, Hsin-Chih Yeh, Andrew Dunn, Douglas Shepherd, James Werner

Proceedings Volume 8950, 895003 (2014) https://doi.org/10.1117/12.2038197

KEYWORDS: 3D image processing, Image resolution, Microscopes, Point spread functions, Imaging systems, Calibration, Molecules, 3D image enhancement, Tissues, Image processing

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SPIE Journal Paper | 24 September 2013 Open Access

Laser speckle contrast imaging of blood flow in rat retinas using an endoscope

Adrien Ponticorvo, Damon Cardenas, Andrew Dunn, Daniel Ts'o, Timothy Duong

JBO, Vol. 18, Issue 09, 090501, (September 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.9.090501

KEYWORDS: Blood circulation, Laser speckle contrast imaging, Retina, Endoscopes, Visualization, Speckle, Reflectivity, Cornea, Eye, Hyperoxia

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SPIE Journal Paper | 2 May 2013 Open Access

Dual-wavelength photothermal optical coherence tomography for imaging microvasculature blood oxygen saturation

Biwei Yin, Roman Kuranov, Austin McElroy, S. M. Shams Kazmi, Andrew Dunn, Timothy Duong, Thomas Milner

JBO, Vol. 18, Issue 05, 056005, (May 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.5.056005

KEYWORDS: Blood, Optical coherence tomography, Blood circulation, Coherence imaging, Signal to noise ratio, Imaging systems, Blood vessels, Interference (communication), Oxygen, Oximeters

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Proceedings Article | 15 February 2013 Paper

Visualization of thermal lensing induced image distortion using Zemax ray tracing and BTEC thermal modeling

Erica Towle, Clifton Clark, Michelle Aaron, Andrew Dunn, Ashley Welch, Robert Thomas

Proceedings Volume 8579, 85790K (2013) https://doi.org/10.1117/12.2001168

KEYWORDS: Eye models, Eye, Visualization, Thermal modeling, Refraction, Zemax, Thermal effects, Visual process modeling, Spatial frequencies, Visual analytics

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SPIE Journal Paper | 15 October 2012 Open Access

Visual disruption using the thermal lensing effect in the human eye: pilot study

Erica Towle, Paul Garcia, Peter Smith, Robert Thomas, Andrew Dunn, Ashley Welch, Brian Foutch

JBO, Vol. 17, Issue 10, 105007, (October 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.10.105007

KEYWORDS: Visualization, Eye, Thermal effects, Cornea, Infrared lasers, Retina, Laser damage threshold, Iris, Safety, Distortion

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Proceedings Article | 9 February 2012 Paper

Intraoperative laser speckle contrast imaging for monitoring cerebral blood flow: results from a 10-patient pilot study

Lisa Richards, Erica Weber, Ashwin Parthasarathy, Kaelyn Kappeler, Douglas Fox, Andrew Dunn

Proceedings Volume 8207, 82074L (2012) https://doi.org/10.1117/12.909078

KEYWORDS: Laser speckle contrast imaging, Electrocardiography, Blood circulation, Microscopes, Cameras, Tissues, Image registration, Speckle, Surgery, Image filtering

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Proceedings Article | 9 February 2012 Paper

Monte Carlo simulation of fluorescence imaging of microvasculature

Mitchell Davis, S. M. Shams Kazmi, Adrien Ponticorvo, Andrew Dunn

Proceedings Volume 8221, 822118 (2012) https://doi.org/10.1117/12.908298

KEYWORDS: Luminescence, Tissues, Sensors, Signal detection, Absorption, 3D modeling, Confocal microscopy, Cameras, Monte Carlo methods, Optical properties

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Proceedings Article | 9 February 2012 Paper

Direct assessment of thermal lensing in ocular media using an artificial eye

Erica Weber, Mike Rickman, Andrew Dunn, Ashley Welch, Robert Thomas

Proceedings Volume 8221, 822106 (2012) https://doi.org/10.1117/12.910716

KEYWORDS: Eye, Infrared radiation, Visualization, Retina, Thermal effects, Visible radiation, Human subjects, Refraction, Near infrared, Eye models

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SPIE Journal Paper | 1 November 2010 Open Access

Laser speckle contrast imaging of cerebral blood flow in humans during neurosurgery: a pilot clinical study

Ashwin Parthasarathy, Erica Weber, Lisa Richards, Douglas Fox, Andrew Dunn

JBO, Vol. 15, Issue 06, 066030, (November 2010) https://doi.org/10.1117/12.10.1117/1.3526368

KEYWORDS: Blood circulation, Laser speckle contrast imaging, Microscopes, Surgery, Speckle, Electrocardiography, Brain, Cameras, Tumors, Cerebral blood flow

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SPIE Journal Paper | 1 September 2010 Open Access

Far-field superposition method for three-dimensional computation of light scattering from multiple cells

Matthew Starosta, Andrew Dunn

JBO, Vol. 15, Issue 05, 055006, (September 2010) https://doi.org/10.1117/12.10.1117/1.3491124

KEYWORDS: Scattering, Superposition, Light scattering, Finite-difference time-domain method, Multiple scattering, Computer simulations, Anisotropy, Biological research, Tissue optics, Tissues

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Proceedings Article | 23 February 2010 Paper

Noise analysis in laser speckle contrast imaging

Shuai Yuan, Yu Chen, Andrew Dunn, David Boas

Proceedings Volume 7563, 75630J (2010) https://doi.org/10.1117/12.842458

KEYWORDS: Laser speckle contrast imaging, Speckle, Physiology, Biomedical optics, Mathematical modeling, Blood circulation, Heart, Animal model studies, Statistical analysis, Statistical modeling

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Proceedings Article | 23 February 2010 Paper

A far-field superposition method for 3D FDTD simulations of light scattering from multiple biological cells

Matthew Starosta, Andrew Dunn

Proceedings Volume 7562, 756206 (2010) https://doi.org/10.1117/12.849140

KEYWORDS: Scattering, Superposition, Finite-difference time-domain method, Multiple scattering, Computer simulations, Anisotropy, Light scattering, Tissue optics, Biological research, Refractive index

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Proceedings Article | 18 February 2010 Paper

Spatial mapping of oxygen levels in the brain using a digital micromirror device

Andrew Dunn, Adrien Ponticorvo

Proceedings Volume 7596, 759606 (2010) https://doi.org/10.1117/12.845283

KEYWORDS: Digital micromirror devices, Blood circulation, Speckle, Oxygen, Phosphorescence, Cameras, Brain, Brain mapping, In vivo imaging, Temporal resolution

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SPIE Journal Paper | 1 January 2010 Open Access

Laser speckle contrast imaging in biomedical optics

David Boas, Andrew Dunn

JBO, Vol. 15, Issue 01, 011109, (January 2010) https://doi.org/10.1117/12.10.1117/1.3285504

KEYWORDS: Speckle, Blood circulation, Laser speckle contrast imaging, Scattering, Brain, Speckle pattern, Statistical analysis, Light scattering, Hemodynamics, Particles

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SPIE Journal Paper | 1 July 2009 Open Access

Sensitivity of neural-hemodynamic coupling to alterations in cerebral blood flow during hypercapnia

Theodore Huppert, Phill Jones, Anna Devor, Andrew Dunn, Ivan Teng, Anders Dale, David Boas

JBO, Vol. 14, Issue 04, 044038, (July 2009) https://doi.org/10.1117/12.10.1117/1.3210779

KEYWORDS: Blood circulation, Oxygen, Hemodynamics, Blood, Cerebral blood flow, Brain, Mode conditioning cables, Data modeling, Physiology, Resistance

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Proceedings Article | 24 February 2009 Paper

Three-dimensional computation of focused beam propagation through multiple biological cells

Matthew Starosta, Andrew Dunn

Proceedings Volume 7187, 71870I (2009) https://doi.org/10.1117/12.809433

KEYWORDS: Scattering, Laser scattering, Finite-difference time-domain method, Luminescence, Point spread functions, Light scattering, Computer simulations, Optical simulations, Refractive index, Tissue optics

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Proceedings Article | 18 February 2009 Paper

Two-photon-induced photoluminescence imaging of gold nanoshell's tumor biodistribution

Jaesook Park, Arnold Estrada, Jon Schwartz, Parmeswaran Diagaradjane, Sunil Krishnan, Chris Coleman, J. Donald Payne, Andrew Dunn, James Tunnell

Proceedings Volume 7192, 71920T (2009) https://doi.org/10.1117/12.809620

KEYWORDS: Tumors, Satellite navigation systems, Luminescence, Gold, Tissues, Tissue optics, Cancer, Multiplexing, Particles, Microscopes

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SPIE Journal Paper | 1 July 2008 Open Access

Simultaneous multispectral reflectance imaging and laser speckle flowmetry of cerebral blood flow and oxygen metabolism in focal cerebral ischemia

Phill Jones, Hwa Kyuong Shin, David Boas, Bradley Hyman, Michael Moskowitz, Cenk Ayata, Andrew Dunn

JBO, Vol. 13, Issue 04, 044007, (July 2008) https://doi.org/10.1117/12.10.1117/1.2950312

KEYWORDS: Multispectral imaging, Reflectivity, Scattering, Ischemia, Hemodynamics, Speckle, Oxygen, Monte Carlo methods, Chromophores, Mode conditioning cables

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Proceedings Article | 21 February 2008 Paper

3D microscopy of gold nanoshells in tumors using two-photon-induced photoluminescence

Jaesook Park, Arnold Estrada, Jon Schwartz, J. Donald Payne, Andrew Dunn, James Tunnell

Proceedings Volume 6869, 68690L (2008) https://doi.org/10.1117/12.764123

KEYWORDS: Luminescence, Tumors, Gold, 3D image processing, Particles, 3D acquisition, Near infrared, Microscopy, Cancer, Silica

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Proceedings Article | 20 February 2008 Paper

Enhancement of light in tissue using hyper-osmotic agents

Raiyan Zaman, Bo Chen, Ashwin Parthasarathy, Arnold Estrada, Ardien Ponticorvo, Henry Rylander, Andrew Dunn, Ashley Welch

Proceedings Volume 6854, 68541F (2008) https://doi.org/10.1117/12.763241

KEYWORDS: Skin, Speckle, Blood circulation, Blood vessels, Arteries, Veins, Tissue optics, Doppler tomography, Blood, Capillaries

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SPIE Journal Paper | 1 March 2007 Open Access

Cortical blood flow assessment with frequency-domain laser Doppler microscopy

Michael Atlan, Benoît Forget, Claude Boccara, Tania Vitalis, Armelle Rancillac, Andrew Dunn, Michel Gross

JBO, Vol. 12, Issue 02, 024019, (March 2007) https://doi.org/10.1117/12.10.1117/1.2715184

KEYWORDS: Doppler effect, Blood circulation, In vivo imaging, Brain, Light scattering, Laser Doppler velocimetry, Heterodyning, Microscopes, Blood vessels, Imaging systems

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Proceedings Article | 16 February 2007 Paper

Imaging Hemodynamic Effects of ET-1 on Cerebral Blood Flow in Rats

Adrien Ponticorvo, W. Tom, M. Aura, T. Jones, A. Dunn

Proceedings Volume 6446, 64460U (2007) https://doi.org/10.1117/12.700967

KEYWORDS: Speckle, Blood circulation, Laser speckle contrast imaging, Cerebral blood flow, Ischemia, Hemodynamics, Spatial resolution, Doppler effect, Temporal resolution, Animal model studies

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Proceedings Article | 15 February 2007 Paper

Laser speckle contrast imaging of flow in a microfluidic device

Ashwin Parthasarathy, Weon Gyu Shin, X. Zhang, A. Dunn

Proceedings Volume 6446, 644604 (2007) https://doi.org/10.1117/12.700572

KEYWORDS: Speckle, Microfluidics, Laser speckle contrast imaging, Speckle imaging, Tissues, Brain, Blood circulation, Modulation, Liquids, Capillaries

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Proceedings Article | 13 February 2007 Paper

Fluorescence tomography in a murine model of Alzheimer’s disease

Scott Raymond, Anand Kumar, Andrew Dunn, David Boas, Brian Bacskai

Proceedings Volume 6434, 64342H (2007) https://doi.org/10.1117/12.700199

KEYWORDS: Photons, Brain, Absorption, Luminescence, Monte Carlo methods, Reflection, Alzheimer's disease, Quantum efficiency, Image segmentation, Head

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Proceedings Article | 13 March 2006 Paper

Laminar optical tomography: high-resolution 3D functional imaging of superficial tissues

Elizabeth Hillman, Anna Devor, Andrew Dunn, David Boas

Proceedings Volume 6143, 61431M (2006) https://doi.org/10.1117/12.655876

KEYWORDS: Tissues, 3D image processing, Hemodynamics, Light scattering, Absorption, Data acquisition, Sensors, Confocal microscopy, Scattering, Luminescence

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Proceedings Article | 22 November 2005 Paper

Time resolved fluorescence imaging in diffuse media

Anand T. Kumar, Jesse Skoch, Frank Hammond III, Andrew Dunn, David Boas, Brian Bacskai

Proceedings Volume 6009, 60090Y (2005) https://doi.org/10.1117/12.630990

KEYWORDS: Luminescence, Sensors, Modulation, Tissues, Absorption, Reconstruction algorithms, Diffusion, Imaging systems, Tomography, Biological research

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Proceedings Article | 22 November 2005 Paper

Multimodal optical imaging of mouse Ischemic cortex

Phillip Jones, Hwa Kyuong Shin, Andrew Dunn, Bradley Hyman, David Boas, Michael Moskowitz, Cenk Ayata

Proceedings Volume 6009, 60090X (2005) https://doi.org/10.1117/12.630946

KEYWORDS: Chromophores, Scattering, Ischemia, Reflectivity, Speckle, Hemodynamics, Blood, Monte Carlo methods, Optical imaging, Oxygen

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SPIE Journal Paper | 1 January 2005 Open Access

Development of an optical approach for noninvasive imaging of Alzheimer's disease pathology

Jesse Skoch, Andrew Dunn, Bradley Hyman, Brian Bacskai

JBO, Vol. 10, Issue 01, 011007, (January 2005) https://doi.org/10.1117/12.10.1117/1.1846075

KEYWORDS: Brain, Near infrared, Neuroimaging, Positron emission tomography, Luminescence, Tissues, Pathology, Tissue optics, Radio optics, Alzheimer's disease

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Proceedings Article | 10 May 2001 Paper

Spatially-resolved cerebral blood flow imaging using laser speckle

Andrew Dunn, Hayrunnisa Bolay, Michael Moskowitz, David Boas

Proceedings Volume 4260, (2001) https://doi.org/10.1117/12.426780

KEYWORDS: Speckle, Blood circulation, Cerebral blood flow, Speckle imaging, Doppler effect, Speckle pattern, Temporal resolution, Ischemia, Doppler tomography, Particles

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Proceedings Article | 1 June 1999 Open Access

Two-photon excited imaging of photosensitizers in tissues

Mariah Coleno, Vincent Wallace, Chung-Ho Sun, Andrew Dunn, Michael Berns, Bruce Tromberg

Proceedings Volume 3604, (1999) https://doi.org/10.1117/12.349217

KEYWORDS: Tissues, Collagen, Luminescence, Photodynamic therapy, Wound healing, Two photon imaging, Microscopes, Two photon excitation microscopy, Visualization, 3D modeling

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Proceedings Article | 6 May 1999 Open Access

Spatial point spread function with depth in two-photon microscopy

Andrew Dunn, Vincent Wallace, Mariah Coleno, Peter So, Bruce Tromberg

Proceedings Volume 3605, (1999) https://doi.org/10.1117/12.347559

KEYWORDS: Luminescence, Scattering, Monte Carlo methods, Point spread functions, Optical spheres, Optical properties, Signal detection, Two photon imaging, Signal attenuation, Tissue optics

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SPIE Journal Paper | 1 October 1998 Open Access

Near Real Time Confocal Microscopy of Cultured Amelanotic Cells: Sources of Signal, Contrast Agents and Limits of Contrast

Colin Smithpeter, Andrew Dunn, Rebekah Drezek, Thomas Collier, Rebecca Richards-Kortum

JBO, Vol. 3, Issue 04, (October 1998) https://doi.org/10.1117/12.10.1117/1.429853

KEYWORDS: Confocal microscopy, Scattering, Microscopes, Light scattering, In vivo imaging, Breast cancer, Optical spheres, Tissues, Phase contrast, Image resolution

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Proceedings Article | 18 August 1997 Paper

Light scattering from cells and organelles of arbitrary shape

Andrew Dunn, Rebecca Richards-Kortum

Proceedings Volume 2979, (1997) https://doi.org/10.1117/12.280290

KEYWORDS: Scattering, Light scattering, Finite-difference time-domain method, Magnetism, Dielectrics, Refractive index, Tissues, Tissue optics, Refraction, Diagnostics

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SPIE Journal Paper | 1 July 1997 Open Access

Finite-difference time-domain simulation of light scattering from single cells

Andrew Dunn, Colin Smithpeter, Ashley Welch, Rebecca Richards-Kortum

JBO, Vol. 2, Issue 03, (July 1997) https://doi.org/10.1117/12.10.1117/12.275219

KEYWORDS: Scattering, Light scattering, Finite-difference time-domain method, Tissue optics, Mie scattering, Refraction, Tissues, Electromagnetic scattering, Near infrared, Monte Carlo methods

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Proceedings Article | 22 May 1997 Paper

Melanin effect on light scattering in tissues: from electrodynamics of living cells to OCT imaging

Alexander Sergeev, Natalia Gladkova, Felix Feldchtein, Valentin Gelikonov, Grigory Gelikonov, Ludmila Snopova, John Ioannovich, K. Frangia, T. Pirza, Ioannis Antoniou, Andrew Dunn, Rebecca Richards-Kortum

Proceedings Volume 2981, (1997) https://doi.org/10.1117/12.274322

KEYWORDS: Optical coherence tomography, Tissues, Skin, Light scattering, Scattering, Backscatter, Dielectrics, Electrodynamics, Coherence imaging, Absorption

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Showing 5 of 59 publications

Conference Committee Involvement (3)

Clinical and Translational Neurophotonics 2025

25 January 2025 | San Francisco, California, United States

Advances in Microscopic Imaging

25 June 2017 | Munich, Germany

Neurophotonics II

24 June 2015 | Munich, Germany

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